Brain MR Findings in Patients with Systemic Lupus Erythematosus with and without Antiphospholipid Antibody Syndrome

Kaichi, Yoko; Kakeda, Shingo; Moriya, Junji; Ohnari, Norihiro; Saito, Kazuyoshi; Tanaka, Yoshiya; Tatsugami, F; Date, Shuji; Awai, Kozi; Korogi, Yukunori

doi:10.3174/ajnr.a3645

Cited by 63 publications

(34 citation statements)

References 31 publications

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“…SLE fundamentally involves inflammation, which is difficult to detect using conventional MRI. Although many studies with conventional MRI have supplied ample evidence of brain pathology in SLE patients, such as cerebral infarction, brain atrophy and multifocal GM and/or WM lesions, 5 these MR findings may indicate that pathological conditions of the brain occur as a result of SLE-related inflammation. Furthermore, previous investigators have considered that NPSLE may cause changes in brain metabolism and blood flow, which can be detected using several radiographic techniques, including PET, 53 SPECT, 54,55 and advanced MRI techniques such as perfusion-weighted MRI, fMRI and MR spectroscopy.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping

Miyata

Kakeda

Kudo

et al. 2018

J Cereb Blood Flow Metab

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The purposes of this study are to assess the oxygen extraction fraction (OEF) changes on MRI-based quantitative susceptibility mapping (QSM) in systemic lupus erythematosus (SLE) patients and to determine whether QSM-OEF is associated with disease activity in SLE. We enrolled 42 SLE patients and 20 healthy subjects (HS) who had no pathologies on conventional brain MRI. Disease activity was assessed using SLE Disease Activity Index (SLEDAI). For the measurement of QSM-OEF, QSM data were analysed using the Perfusion Mismatch Analyzer software program. Spearman's or Pearson's correlation coefficients were calculated, and independent predictors were identified through a multiple linear regression analysis. QSM-OEF was significantly higher in SLE than that in HS (51.3 ± 10.1 vs. 40.5 ± 3.7, p < 0.001). QSM-OEF was positively correlated with SLEDAI and the presence of neuropsychiatric symptom (NPS) scores (ρ = 0.663, p < 0.001 and ρ = 0.340, p = 0.028). At multiple linear regression analysis, SLEDAI and NPS were independently associated with QSM-OEF (standardized β = 0.426, p = 0.016 and standardized β = 6.148, p = 0.029). In the SLE patients, QSM-OEF is associated with disease activity, which might predict an increased risk of stroke in SLE.

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Section: Discussionmentioning

confidence: 99%

Evaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping

Miyata

Kakeda

Kudo

et al. 2018

J Cereb Blood Flow Metab

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“…Antiphospholipid syndrome (APS) is defined by the presence of lupus anticoagulant (LA) or anti-β2-glycoprotein-I (β2-GPI), which is a subset of anticardiolipin (aCL) antibodies. SLE patients with APS are more likely to develop infarcts, stenotic arterial lesions, and white matter hypertrophy compared with SLE patients without APS [47]. Antiphospholipid antibodies have also been associated with psychosis in one [48] but not another [49].…”

Section: Antiphospholipid Antibodiesmentioning

confidence: 99%

Neuropsychiatric SLE: From Immune Mechanisms to Clinical Management

Zhang¹,

Jørgensen²

2020

Lupus - New Advances and Challenges

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In this chapter, we will describe neuropsychiatric lupus (NPSLE) as it develops and is treated in lupus patients, as well as means to study the disease using animal models. Based on mouse studies, we will discuss the correlation between inflammatory mediators, such as cytokines and autoantibodies, and the development of neurological symptoms with specific emphasis on the evidence for systemic versus local effects. We will describe specifically the effect of these mediators on the blood-brain barrier, microglia cell function, and the immune system. In addition, we will summarize signs and symptoms in NPSLE patients, especially with respect to primary versus drug-induced neurological issues and current treatment strategies. The chapter will offer a comprehensive review of old and new studies in animal models and patient populations and offer insight into how these results align with current treatment strategies offered to patients.

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“…Es gilt ein sekundäres Antiphospholipidsyndrom als Ursache abzugrenzen, da in diesem Fall mindestens eine Thrombozytenfunktionshemmung mit ASS, bei einer Vorgeschichte von Thrombosen oder einem Abort eine Antikoagulation erforderlich ist (24,25). Bei SLE-Patienten mit APLAS findet sich das gesamte Spektrum des ischämischen Schlaganfalls mit territorialen und lakunä-ren Infarkten, Grenzzoneninfarkten sowie Sinus-und Hirnvenenthrombosen (26).…”

Section: Kollagenosen Mit Beteiligung Des Zentralen Und Peripheren Neunclassified

Entzündlich-rheumatische Erkrankungen und neurologische Manifestationen

Röther¹,

Bickel²,

Kötter³

2018

Arthritis und Rheuma

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ZusammenfassungEntzündliche Erkrankungen des peripheren und zentralen Nervensystems sind oft eine Herausforderung, und regelmäßig stellt sich die Frage nach einer entzündlich-rheumatischen Grunderkrankung. Die Erstdiagnose einer Vaskulitis oder einer Kollagenose erfolgt sowohl in der Neurologie als auch in der Rheumatologie und daher benötigen Rheumatologen neurologisches Symptomwissen und Neurologen ein Verständnis der entzündlich-rheumatischen Krankheitszeichen. Die diagnostische Zuordnung kann eindeutig sein, wenn typische Symptomkonstellationen vorhanden und diagnostische Kriterien seitens der zerebralen Bildgebung und der Labordiagnostik passend sind. Häufig ist aber der Nachweis einer entzündlich-rheumatologischen Erkrankung erschwert, und eine enge Kooperation zwischen dem neurologischen und rheumatologischen Fachgebiet ist sinnvoll. Wir geben nachfolgend eine Übersicht über die häufigsten neurologischen Manifestationen entzündlich-rheumatologischer Erkrankungen und deren moderne Therapieoptionen.

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Brain MR Findings in Patients with Systemic Lupus Erythematosus with and without Antiphospholipid Antibody Syndrome

Cited by 63 publications

References 31 publications

Evaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping

Evaluation of oxygen extraction fraction in systemic lupus erythematosus patients using quantitative susceptibility mapping

Neuropsychiatric SLE: From Immune Mechanisms to Clinical Management

Entzündlich-rheumatische Erkrankungen und neurologische Manifestationen

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