History of the Letzte Wiese/Last Meadow Concept of Brain Ischemia

Hossmann, Konstantin‐Alexander; Heiss, Wolf‐Dieter

doi:10.1161/strokeaha.115.010976

Cited by 13 publications

(12 citation statements)

References 47 publications

(37 reference statements)

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“…In healthy subjects, the areas showing the BOLD signal delay seem to correspond well to the watershed areas. Located at the borders of the perfusion territories, these areas supplied by the most distal and smallest branches of the major arteries are known as the regions most vulnerable to a sudden drop in blood pressure or proximal occlusion of the major arteries ( Wodarz, 1980 ; Zülch, 1985 ; Hossmann and Heiss, 2016 ). In the frontal lobes, the areas extending from the anterior horn of the lateral ventricle to the cortex showing delayed BOLD signal ( Figure 1 and Supplementary Figure 2 ) correspond to the anterior watershed areas between the anterior and middle cerebral artery territories.…”

Section: Discussionmentioning

confidence: 99%

“…In the frontal lobes, the areas extending from the anterior horn of the lateral ventricle to the cortex showing delayed BOLD signal ( Figure 1 and Supplementary Figure 2 ) correspond to the anterior watershed areas between the anterior and middle cerebral artery territories. On the other hand, the parieto-temporo-occipital wedge-shaped-delayed regions extending from the occipital horn of the lateral ventricle to the cortex ( Figure 1 and Supplementary Figure 2 ) correspond to posterior watershed areas ( Wodarz, 1980 ; Zülch, 1985 ; Hossmann and Heiss, 2016 ). Importantly, given that the BOLD response is dependent on the local hemodynamics, it is considered the local vascularity rather than the geographical localization of each region that matters.…”

Section: Discussionmentioning

confidence: 99%

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Origin of the Time Lag Phenomenon and the Global Signal in Resting-State fMRI

2020

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The global mean signal of resting-state fMRI (rs-fMRI) shows a characteristic spatiotemporal pattern that is closely related to the pattern of vascular perfusion. Although being increasingly adopted in the mapping of the flow of neural activity, the mechanism that gives rise to the BOLD signal time lag remains controversial. In the present study, we compared the time lag of the global mean signal with those of the local network components obtained by applying temporal independent component analysis to the resting-state fMRI data, as well as by using simultaneous wide-field visual stimulation, and demonstrated that the time lag patterns are highly similar across all types of data. These results suggest that the time lag of the rs-fMRI signal reflects the local variance of the hemodynamic responses rather than the arrival or transit time of the stimulus, whether the trigger is neuronal or non-neuronal in origin as long as it is mediated by local hemodynamic responses. Examinations of the internal carotid artery signal further confirmed that the arterial signal is tightly inversely coupled with the global mean signal in accordance with previous studies, presumably reflecting the blood flow or blood pressure changes that are occurring almost simultaneously in the internal carotid artery and the cerebral pial/capillary arteries, within the low-frequency component in human rs-fMRI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Origin of the Time Lag Phenomenon and the Global Signal in Resting-State fMRI

2020

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“…В том случае, когда функционирование механизмов регуляции мозгового кровообращения оказывается неэффективным, мозговой кровоток пассивно следует за системным АД и его уровень снижается в условиях артериальной гипотензии [39]. Нарушения кровотока в этой ситуации описываются концепцией «последнего луга», в соответствии с которой поражение крупных мозговых или внечерепных магистральных артерий приводит к гипоперфузии в зонах смежного кровообращения, расположенных между областями, получающими кровь из систем передней, средней и задней мозговых артерий, а также в области подкорковых ганглиев и внутренней капсулы [40].…”

Section: нарушения регуляции мозгового кровообращенияunclassified

Pathogenesis of chronic disorders of cerebral circulation

Камчатнов¹,

Chugunov²,

Tyazhelnikov³

et al. 2017

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Chronic disorders of cerebral circulation are a common syndrome, in the pathogenesis of which the important role play structural and functional alterations in large and small arteries, autoregulation of cerebral circulation and the level of systemic arterial pressure. Drugs that increase cerebral blood flow and restore the ability to its autoregulation are used, among others, in treatment of patients with CRMC. The possibility of using nicergoline (sermion) for the treatment of patients with CRMK is considered.

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“…The etiology of BZI is still under researching but some studies supposed internal BZI to be due to hemodynamic compromise secondary to proximal stenosis and/or hypo-perfusion due to low cardiac output, whereas cortical BZI were linked to embolization either from the heart or atherosclerotic plaques in large arteries (Hossmann and Heiss 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Cerebral border zone infarction: an etiological study

El-Gammal

Bahnasy

Al-Malt

2018

Egypt J Neurol Psychiatry Neurosurg

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BackgroundBorder zone infarcts (BZI) are ischemic lesions at the junction between two main arterial territories which may be either cortical or internal BZI.MethodsThis study was conducted on 76 cerebral BZI patients and 20 healthy control subjects. Patients were divided to group I included 26 internal BZI, group II included 19 cortical BZI and group III included 21 mixed internal/cortical BZI patients. Included subjects were submitted to neurological examination, laboratory investigations, ECG, echocardiogram, brain CT and/or MRI and extra and intracranial blood vessels imaging by duplex and CT angiography.ResultsHypertension was significantly higher among groups I and III compared to group II while atrial fibrillation (AF) was significantly higher in groups II and III than group I (p < 0.05). Sonographic duplex assessment of extra and intracranial blood vessels revealed significant increase in mean flow velocities of CCA, ICC and MCA on both side in groups I and III compared to group II (p < 0.05). CT angiography revealed non-significant differences between BZI patients and control as well as in between the three BZI patient’s groups regarding the existence of vertebral artery hypoplasia and/or circle of Willis anomalies.ConclusionsVascular stenosis is the main etiological factor in internal BZI while AF is the predominant etiological factor of cortical BZI. Congenital vascular anomalies play roles in the localization of BZI but cannot predispose to it except when comorbid with hemodynamic disturbances.

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History of the Letzte Wiese/Last Meadow Concept of Brain Ischemia

Cited by 13 publications

References 47 publications

Origin of the Time Lag Phenomenon and the Global Signal in Resting-State fMRI

Origin of the Time Lag Phenomenon and the Global Signal in Resting-State fMRI

Pathogenesis of chronic disorders of cerebral circulation

Cerebral border zone infarction: an etiological study

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