Differential liquid phase proteomic analysis of the effect of selenium supplementation in LNCaP cells

Roveri, Antonella; Vitale, Maria Pia; Serain, Elena; Zaccarin, Mattia; Mauri, Pierluigi; Silvestre, Dario Di; Palma, Antonella De; Gion, Massimo; Toppo, Stefano; Maiorino, Matilde; Ursini, Fulvio

doi:10.1016/j.jchromb.2008.02.010

Cited by 5 publications

(1 citation statement)

References 25 publications

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“…These studies have also shown that androgen receptor status may influence the effect of selenium on gene expression profile in prostate cancer (8). Proteomic approaches, employed to elucidate changes in prostate cancer cells associated with selenium supplementation, have also identified several novel targets (9, 10). Furthermore, a clinical study showed that short-term (3–6 weeks) supplementation of selenomethionine combined with vitamin E in men with organ-confined prostate cancer induced statistically significant proteomic pattern changes associated with prostate cancer-free status (11).…”

Section: Selenium and Prostate Cancer Prevention: The Evidencementioning

confidence: 99%

Potential Stages for Prostate Cancer Prevention with Selenium: Implications for Cancer Survivors

Facompre

El‐Bayoumy

2009

Cancer Research

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The lack of treatment for ''worried well'' patients with highgrade prostatic intraepithelial neoplasia combined with issues of recurrence and hormone resistance in prostate cancer survivors remains a major public health obstacle. The long latency of prostate cancer development provides an ample opportunity to intervene with mechanistically based chemopreventive agents at various stages of disease progression. Our rationale for selenium intervention is based on current mechanistic knowledge derived solely from preclinical investigations. Clearly, there is sufficient scientific support for its entry into current clinical trials, the outcome of which will be highly valuable in assessing whether selenium can be recommended for cancer survivors.

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