Potential Stages for Prostate Cancer Prevention with Selenium: Implications for Cancer Survivors

Facompre, Nicole D.; El‐Bayoumy, Karam

doi:10.1158/0008-5472.can-08-4359

Cited by 45 publications

(38 citation statements)

References 17 publications

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Section: Introductionmentioning

confidence: 99%

“…Diet-derived agents including selenium have been shown to have chemopreventive potential against PC (2, 3). Epidemiological and laboratory investigations have shown that dietary selenium is protective against the development of cancer at many sites including the prostate (3–7). In the Nutritional Prevention of Cancer (NPC) study (8), supplementation with selenium-enriched yeast (SY) in men was associated with an ~50% reduction in cancer morbidity and mortality, including a 63% decrease in PC incidence, with subjects having low baseline plasma selenium levels (<122 ng/ml) showing the greatest benefit (9).…”

Section: Introductionmentioning

confidence: 99%

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Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial

Richie

Das

Sinha

et al. 2014

Cancer Prevention Research

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Epidemiological and laboratory studies indicate that dietary selenium protects against prostate cancer. Results from clinical trials suggest that selenium-enriched yeast (SY) but not selenomethionine (SeMet) may be effective at reducing prostate cancer risk. Our objectives were to directly compare for the first time the effects of SeMet and SY on prostate cancer relevant biomarkers in men. We performed a randomized double blind, placebo-controlled trial of SY (200 or 285 µg/day) and SeMet (200 µg/day) administered for 9 months in 69 healthy men. Primary endpoints included blood levels of selenium-containing compounds and oxidative stress biomarkers (urine 8-hydroxy-2’-deoxyguanosine [8-OHdG] and 8-iso-prostaglandin-F2α [8-iso-PGF2α] and blood glutathione [GSH]). Secondary endpoints included plasma glucose and PSA levels. Compliance was high in all groups (>95%). Plasma selenium levels were increased 93%, 54%, and 86% after 9 months in SeMet and low and high dose SY groups, respectively, and returned to baseline levels after a 3 month washout (P<0.05). Levels of 8-OHdG and 8-iso-PGF2α, were decreased 34% and 28%, respectively, after 9 months in the high dose SY group (P<0.05). These decreases were greatest in individuals with low baseline plasma levels of selenium (<127 ng/ml). No changes in serum PSA or blood glucose and GSH were observed. Overall, we showed for the first time, reductions in biomarkers of oxidative stress following supplementation with SY but not SeMet in healthy men. These findings suggest that selenium-containing compounds other than SeMet may account for the decrease in oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial

Richie

Das

Sinha

et al. 2014

Cancer Prevention Research

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“…Selenium, a component of selenoproteins, is known as an anti-cancer agent, and is used in therapies against prostate cancer (Facompre and El-Bayoumy, 2009). Tran et al (2009) demonstrated the effectiveness of 0.2% selenium coating on cellulose dressings for wounds against P. aeruginosa and S. aureus.…”

Section: Introductionmentioning

confidence: 99%

Antibacterial effects of pure metals on clinically important bacteria growing in planktonic cultures and biofilms

Alquthami¹,

Johny²,

Wainwright³

2014

Afr. J. Microbiol. Res.

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Antibiotic resistance in pathogenic bacteria is emerging as an issue of serious concern in bio-medical research as well as food and health organizations. Metal complexes are currently being employed in medical devices for their inhibition to bacterial adherence and antibacterial activities. The primary aim of this study was to evaluate the antibacterial activities of pure metals, including selenium, germanium and lithium on planktonic cultures and biofilms of three bacterial species: S. aureus SH1000, P aeruginosa PA01 and E. coli. O157:H7. The antagonistic effects of selenium, germanium and lithium on these three bacterial species were examined using zone of inhibition assay. The minimum inhibitory concentrations and minimum bactericidal concentrations of antibiotics (rifampicin, mupirocin and ciprofloxacin) and metals (selenium, germanium and lithium) were measured. The minimum biofilm eradication concentrations (MBEC) of metals were determined against biofilms composed of S. aureus SH1000 and P. aeruginosa PA01. Metal susceptibility tests suggested that biofilms displayed increased resistance over their planktonic state. Differential inhibitory effects were observed for different strains of planktonic and biofilm bacteria in response to different metals and their varying concentrations. Amongst the three metals tested, selenium proved to be the most active against all three species, whereas lithium demonstrated the least inhibitory effects. Scanning electron microscope (SEM) image analysis revealed several detrimental structural changes in bacterial cells exposed to metals compared to those grown in the metal-free culture. In conclusion, the results demonstrate the antibacterial efficacy of pure metals against planktonic and biofilm bacteria paving the way for further similar investigations in search of alternative antibacterial agents.

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“…Basic research and clinical trials strongly support the protective role of selenium against various types of cancer. This effect was more remarkable in prostate and colorectal cancers [6][7][8]. A recent report from the Selenium and Vitamin E Cancer Prevention Trial (SELECT) demonstrated that selenium or vitamin E, either alone or in combination did not prevent prostate cancer or secondary cancers [9].…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, crystal structure and cytotoxicity of 2,4-bis(selenomethyl)quinazoline

et al. 2011

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Organoselenium compounds have already been reported to be good anticarcinogenic candidates. A new selenoquinazoline derivative, 2,4-bis(selenomethyl)quinazoline (compound 1), has been synthesized, spectroscopically characterized and its crystal structure has been studied. An intermolecular coupling between C 2 and H 0 5 in the Heteronuclear Multiple Bond Correlation (HMBC) experiment has been observed. Assuming that the headto-tail overlap of parallel molecules (as identified by X-ray diffraction) remains in solution to give bimolecular entities, the p-p interaction enables heteronuclear coupling between the former atoms with a three-bond distance [C 2 ÁÁÁ(p-p)ÁÁÁC 0 5 -H 0 5 ]. The crystal structure of compound 1 has been solved by X-ray diffraction. It crystallizes in triclinic system, space group P-1. Unit cell parameters are a = 7.4969(7) Å , b = 8.7008(8) Å , c = 10.1666(9) Å , a = 110.215(2)°, b = 90.354(2)°, c = 115.017(1)°. Linear chains in crystals of compound 1 are generated by C-HÁÁÁSe and SeÁÁÁSe bonds between molecules. Furthermore, head-to-tail overlap of parallel molecules, in which p-p interactions can occur, is observed. Compound 1 exhibited a cytotoxic effect in all of the evaluated tumoral cell lines and showed a higher cytotoxic effect in colon and breast cancer cell lines than etoposide, which was used as a reference compound.

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Potential Stages for Prostate Cancer Prevention with Selenium: Implications for Cancer Survivors

Cited by 45 publications

References 17 publications

Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial

Comparative Effects of Two Different Forms of Selenium on Oxidative Stress Biomarkers in Healthy Men: A Randomized Clinical Trial

Antibacterial effects of pure metals on clinically important bacteria growing in planktonic cultures and biofilms

Synthesis, characterization, crystal structure and cytotoxicity of 2,4-bis(selenomethyl)quinazoline

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