Differences in Immunomodulating Effects Between Wild and Cultured Panax ginseng

Immuno-regulatory Effects of CKBM on the Activities of Mitogen-Activated Protein Kinases and the Release of Cytokines in THP-1 Monocytic Cells

“…This indicates that the active constituents in CKBM are likely to act on specific cellular targets which become saturated when the CKBM concentration is gradually increased. Although the direct molecular targets of these chemical constituents have not been fully defined, the immuno-modulatory effects of some CKBM herbal components have been well-established, 7,10) and their clinical value proven through the prescription of traditional Chinese medicine.…”

“…All of the herbal components in CKBM are defined as therapeutic agents in terms of Chinese medicine, and consumed by millions of people for many centuries. The water extract of Panax ginseng stimulates the immune responses in both helper and cytotoxic T lymphocytes, 7) and some of its chemical constituents (e.g. ginsenoside Rg1) have a protective effect against neurodegenerative diseases.…”

“…8) Schisandra chinensis contains lignans which are effective apoptotic agents against lung carcinoma cells 7) and may act as an enhancing agent in the treatment for acute promyelocytic leukemia.…”

PC-SPES and Prostate Cancer

“…Rg1, a saponin derived from Panax ginseng, has been shown to stimulate lymphocytes (Liu et al 1995). Similarly, a hot water extract of P. ginseng is mitogenic toward T cells, both in vivo and in vitro, and the in vitro activity is comparable to that of Concanavalin A (Mizuno et al 1994). Of particular relevance to the development of metastases, ginsenoside-Rb2 inhibits angiogenesis in B16 melanoma cells in vivo (Sato et al 1994).…”

In vivo antimetastatic and immunomodulating activity of phytomix-40

“…In vitro and in vivo animal experiments demonstrated that phytoadaptogens normalized phagocytic and cytolytic activities of macrophages and polymorphonuclear leukocytes [ 1,9,10], the content and functions of helper and cytotoxie T lymphocytes [ 11,12,14,15]. Clinical studies demonstrated normalization of the immune status, primarily T-cell immunity in patients with breast cancer, ovarian cancer, skin melanoma, etc.…”