Dietary nucleotides: a novel supplement in fish feeds

Burrells, C.; Williams, Paul; Southgate, Peter; Wadsworth, Simón

doi:10.1016/s0044-8486(01)00576-2

Cited by 189 publications

(24 citation statements)

References 23 publications

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“…In fact, experiment 2 demonstrated that the fish were only able to recover their innate immunity at 24 hr poststress (Figure 1). This also is in line with what Burrells, Williams, Southgate, and Wadsworth (2001) observed, in which stressful events related to various aquaculture practices such as vaccination, handling and disease exposure may increase the need for dietary nucleotides to provide optimal responses of the fish.…”

Section: Ta B L Esupporting

confidence: 90%

Exploring potential synergistic effects between dietary adenosine and inosine monophosphate on growth performance and acute stress‐induced immune responses of hybrid striped bassMorone chrysops × Morone saxatilis

et al. 2020

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Two experiments were carried out to evaluate the effects of dietary adenosine monophosphate (AMP) and inosine monophosphate (IMP) on growth performance and acute stress‐induced immune response of hybrid striped bass (HSB). Nine isonitrogenous and isolipidic diets were prepared including a basal diet and eight treatments consisting of singular or combined additions of 0.5% AMP and 0.5% IMP, and combinations of 0.25% AMP and 0.25% IMP from each of two suppliers, Sigma‐Aldrich and Chem‐Impex. The first experiment included two 9‐weeks feeding trials in which triplicate groups of HSB (~9.7 g) were fed the experimental diets. Dietary 0.5% IMP (C‐Impex) showed significantly higher stimulation index of B‐lymphocyte proliferation compared with other dietary treatments. However, no significant synergistic effects between AMP and IMP supplementation were observed in production performance. In a subsequent experiment, HSB (~59.3 g) were fed the diets described previously for 2 weeks and subjected to a standardized acute stress challenge. Fish fed some of the dietary nucleotide treatments had significant enhancement of innate immunity at 0.5 and 12 hr poststress challenge compared with those fed the basal diet. Dietary 0.5% AMP (Chem‐Impex) provided the best capability for enhancing innate immunity during poststress and resistance to stress‐induced immunosuppression.

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Section: Ta B L Esupporting

confidence: 90%

Exploring potential synergistic effects between dietary adenosine and inosine monophosphate on growth performance and acute stress‐induced immune responses of hybrid striped bassMorone chrysops × Morone saxatilis

et al. 2020

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“…Because of those immunomodulative effects, nucleotides have the potential to replace antibiotic use in aquaculture (Li & Gatlin, 2006). Moreover, dietary nucleotides have also induced morphological change in intestine including enhanced lateral branch of intestinal fold of Atlantic salmon Salmo salar (Burrells, Williams, Southgate, & Wadsworth, 2001) and also increased enterocyte height in the distal and proximal intestine and in the pyloric caeca of juvenile red drum Sciaenops ocellatus (Cheng, Buentello, & Gatlin, 2011). Dietary nucleotides also affected on intestinal microbiota by reducing butyrate-producing species in juvenile hybrid tilapia Oreochromis niloticus × O. aureus (Xu et al, 2015).…”

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confidence: 99%

Effect of nucleotides supplementation to low‐fish meal feed on long‐chain polyunsaturated fatty acid composition of juvenile rainbow troutOncorhynchus mykiss

et al. 2019

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A feeding trial was conducted to evaluate the effect of nucleotides supplementation to low‐fish meal feed on growth and fatty acid composition of rainbow trout. Six isonitrogenous (42% crude protein) and isolipidic (18% crude lipid) diets were formulated containing fish meal and plant ingredients as main protein sources. The control diet was a basal diet without supplementation of nucleotides, and five experimental diets were prepared by supplementing one of the five different nucleotides in the form of 5′‐monophosphate (0.15%), that is inosine (IMP), adenosine (AMP), guanosine (GMP), uridine (UMP) and cytidine (CMP) onto basal diet. Two hundred forty juvenile rainbow trout with an initial average body weight 9.8 g were randomly distributed into twelve aquaria. After 15 weeks of feeding period, growth performance and feed utilization of rainbow trout were not significantly different among dietary treatments. Dietary GMP, UMP and CMP tended to accumulate crude lipid in the muscle and whole fish body. Moreover, dietary GMP, UMP and CMP significantly increased hepatic 18:3n‐3 and long‐chain homologue 18:4n‐3 and 20:4n‐3 contents. Hepatic 18:2n‐6 content showed also increase in fish fed GMP, UMP and CMP diets, but decreased in long‐chain homologue 20:3n‐6 and 20:4n‐6 contents. Decrease in 20:4n‐6, 20:5n‐3 and 22:6n‐3 contents was also found in the muscle of fish fed IMP, GMP and CMP diets. The present study clearly showed that there was no positive effect of dietary nucleotides on growth of fish, but dietary nucleotides particularly GMP, UMP and CMP altered polyunsaturated fatty acid composition of rainbow trout.

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“…It is well documented that dietary NT increases tolerance of fish to a variety of stressors (Burrells et al, 2001;Hossain et al, 2016bHossain et al, , 2016cHossain et al, , 2016dLeonardi et al, 2003;Tahmasebi-Kohyani et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Comparative assessment of purine nucleotides adenosine, guanosine and inosine monophosphates as functional supplements on growth and health performances of red sea bream,Pagrus majorjuvenile

et al. 2020

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Purine nucleotides regulate the cellular functions in the animal body. The current study evaluates the comparative efficacy of dietary purine nucleotides, that is, adenosine monophosphate (AMP), guanosine monophosphate (GMP) and inosine monophosphate (IMP) in red sea bream Pagrus major. Semi‐purified basal diet was formulated (Control, D1) containing 550 g/kg protein, supplemented with purine nucleotides AMP, GMP and IMP at their optimum supplementation level (2, 4 and 4 g/kg) to formulate the experimental diet groups D2, D3 and D4, respectively. Initial weight of 3.5 ± 0.01 g fish was randomly fed test diets in triplicate. After 56 days, % weight gain (p = .003), specific growth rate (p = .003) and apparent lipid digestibility (p = .04) were significantly higher in fish fed diet group D4 followed by D3 and D2. Supplemented groups showed significantly higher feed intake in comparison to control (p = .001). Supplemented groups showed significantly increased and decreased NBT (p = .003) and CAT (p = .003) activity, respectively. Fish fed IMP supplemented diets had significantly lower blood urea nitrogen (p = .04), glutamyl oxaloacetic transaminase (p = .04) and glutamic‐pyruvate transaminase (p = .001) followed by other supplemented groups. Supplemented diet groups showed enhanced stress resistance. Interestingly, D2 and D4 groups showed best oxidative stress status of fish. Therefore, these results indicated that among purine nucleotides, supplementation of IMP could be a more effective nucleotide as functional supplement in red sea bream diet.

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Dietary nucleotides: a novel supplement in fish feeds

Cited by 189 publications

References 23 publications

Exploring potential synergistic effects between dietary adenosine and inosine monophosphate on growth performance and acute stress‐induced immune responses of hybrid striped bassMorone chrysops × Morone saxatilis

Exploring potential synergistic effects between dietary adenosine and inosine monophosphate on growth performance and acute stress‐induced immune responses of hybrid striped bassMorone chrysops × Morone saxatilis

Effect of nucleotides supplementation to low‐fish meal feed on long‐chain polyunsaturated fatty acid composition of juvenile rainbow troutOncorhynchus mykiss

Comparative assessment of purine nucleotides adenosine, guanosine and inosine monophosphates as functional supplements on growth and health performances of red sea bream,Pagrus majorjuvenile

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