Dietary Manipulations of Body Fat-reducing Potential of Conjugated Linoleic Acid in Rats

Sugano, Michihiro; Akahoshi, Asuka; Koba, Kazunori; Tanaka, Kazunari; Okumura, Tomoka; Matsuyama, Hiroyuki; Goto, Yusuke; Miyazaki, Tomoko; Murao, Kayoko; Yamasaki, Masao; Nonaka, Michiko; Yamada, Koji

doi:10.1271/bbb.65.2535

Cited by 43 publications

(23 citation statements)

References 35 publications

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“…[8][9][10] Leptin, a kind of adipocytokine exclusively produced in adipose tissue, plays a crucial role in the regulation of adipogenesis. 11,12) In our preceding study, in which rats were fed 1z CLA, 13) the serum level of leptin and TNF-a did not change even though there was a signiˆcant reduction of the weight of the adipose tissues. In contrast, when 2z CLA was fed to rats, the leptin level declined quickly but temporarily.…”

mentioning

confidence: 75%

“…18) SES neither aŠected these parameters, nor increased liver weight further as in the case of rats. 13) The weight of adipose tissues was decreased markedly by dietary CLA in relation to LA (Fig. 1).…”

mentioning

confidence: 89%

“…Sesamin is a potent stimulator of fatty acid b-oxidation in the liver of rats, 16) and indeed augmented the body fat reducing activity of CLA in this animal species. 13) Three-week-old male Crj:CD-1 (ICR) mice were purchased from Japan Charles River Co., Tokyo and housed 5 mice in one stainless steel wire cage in an air-conditioned room (20 to 239 C, lights on 0800 to 2000). During a run-in period of 5 days, mice received a commercial powdered diet (Type NMF, Oriental Yeast Co., Tokyo).…”

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confidence: 99%

“…In rats, SES augmented the reduction by CLA of the weight of perirenal adipose tissues. 13) Figrure 2 shows the eŠects of dietary manipulations on concentrations of serum cytokines. Serum leptin and TNF-a levels were decreased signiˆcantly by dietary CLA.…”

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confidence: 99%

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Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice

Akahoshi

Goto

Murao

et al. 2002

Bioscience, Biotechnology, and Biochemistry

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confidence: 75%

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confidence: 89%

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confidence: 99%

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confidence: 99%

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Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice

Akahoshi

Goto

Murao

et al. 2002

Bioscience, Biotechnology, and Biochemistry

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“…7 -9 Moreover, it has also been shown in animal experiments that the effect of CLA on the reduction of body fat is enhanced by simultaneously ingesting an isolated soy protein. 10 The present study was a randomized, double-blind, placebo-controlled trial to compare the effects of ingesting a mixture of lysine, proline, alanine and arginine, alone or in combination with ingesting CLA before and after exercising.…”

Section: Supplements To Enhance the Fat-burning Effects Of Exercisementioning

confidence: 99%

Evaluation of the Antiobesity Effects of an Amino Acid Mixture and Conjugated Linoleic Acid on Exercising Healthy Overweight Humans: A Randomized, Double-blind, Placebo-controlled Trial

Michishita

Kobayashi²,

Katsuya

et al. 2010

J Int Med Res

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This single-centre, randomized, doubleblind, placebo-controlled trial investigated the effects of administering a mixture of four amino acids (lysine, proline, alanine and arginine) with or without conjugated linoleic acid to healthy overweight humans before and after exercising. Fortyone healthy subjects (body mass index ≥ 23 to < 30 kg/m 2 ) completed the study following randomization to receive either placebo or one of three test supplements: amino acid mixture 0.76 g/day; amino acid mixture 1.52 g/day; or amino acid mixture 1.52 g/day coadministered with conjugated linoleic acid 1.6 g/day. Each of the study treatments was administered 30 min before and immediately after a period of daily exercise, which was delivered by an exercise expert, for a period of 12 weeks. When compared with the placebo group, several indicators, such as waist and hip circumferences, were found to have significantly decreased in the test supplement groups compared with the placebo. These results suggest that ingestion of these supplements might enhance the fat-burning effects of exercise.

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Nutrigenomics and Proteomics in Health and Disease

Mine¹,

Miyashita²,

Shahidi³

2009

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Dietary Manipulations of Body Fat-reducing Potential of Conjugated Linoleic Acid in Rats

Cited by 43 publications

References 35 publications

Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice

Conjugated Linoleic Acid Reduces Body Fats and Cytokine Levels of Mice

Evaluation of the Antiobesity Effects of an Amino Acid Mixture and Conjugated Linoleic Acid on Exercising Healthy Overweight Humans: A Randomized, Double-blind, Placebo-controlled Trial

Nutrigenomics and Proteomics in Health and Disease

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