Evaluation of the Antiobesity Effects of an Amino Acid Mixture and Conjugated Linoleic Acid on Exercising Healthy Overweight Humans: A Randomized, Double-blind, Placebo-controlled Trial

Michishita, T; Kobayashi, S; Katsuya, Tomohiro; Ogihara, Toshio; Kawabuchi, Koichi

doi:10.1177/147323001003800311

Cited by 21 publications

(9 citation statements)

References 23 publications

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“…It has been reported that a reduction of 1 cm in the WC corresponds to a reduction of 1 kg of visceral fat. Moreover, it has also been reported that, if WC is increased by 1 cm, the risk for the development of hypertension is increased by 2.49 times [42]. In the present study, the increased BMI and WC in HFD fed animals demonstrated the efficiency of HFD to induce obesity in these animals.…”

Section: Discussionsupporting

confidence: 74%

Evaluation of anti-obesity potential of aqueous extract of Achyranthes aspera Linn. in high fat diet induced obese rats

et al. 2020

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Background Obesity, reached epidemic proportions globally is often associated with life threatening comorbidities. The unavailability of safe and effective long term medications for obesity in modern pharmacotherapy forces the scientific community to explore the potential of Ayurvedic traditional healers as they are considered safe and effective. Objective To explore the anti-obesity potential of aqueous extract of aerial parts of Achyranthes aspera L. (AEAA), a traditional healer in high fat diet (HFD) induced obese rats. Methods AEAA was prepared and subjected to in-vitro pancreatic lipase inhibition assay and in-vivo anti-obesity studies. For in-vivo studies, HFD fed obese prone Wistar albino rats were divided into five experimental groups (Group II to VI): animals fed with standard pellet chow served as normal control (Group I) while, animals continued with HFD alone served as obese control (Group II); Group III, IV and V were administered AEAA at a dose of 100, 200 and 300 mg/kg b.w. respectively along with HFD; and animals administered orlistat (30 mg/kg bw) along with HFD served as standard control (Group VI). All the drugs were administered orally once a day for a period of 60 days. At the end of the experimental period various physical, biochemical and histopathological observations were made. Results In-vitro studies showed AEAA partially but not significantly inhibited the activity of pancreatic lipase. Data of in-vivo studies revealed, significant reduction in body weights, fat pad weights and organ weights upon AEAA treatment. Elevated levels of glucose, insulin, leptin, lipid profiles and antioxidant status were also brought back to normal. Conclusion The obtained results clearly suggested that AEAA possess pronounced anti-obesity potential.

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Section: Discussionsupporting

confidence: 74%

Evaluation of anti-obesity potential of aqueous extract of Achyranthes aspera Linn. in high fat diet induced obese rats

et al. 2020

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“…In addition, CLA did not affect the β-oxidation rate of fatty acids or induce significant alterations in the safety markers tested. MICHISHITA et al, 2010 [ 67 ] Forty-one healthy subjects Single-centre, randomized, double-blind, placebo-controlled trial Subjects were randomized to receive either placebo or one of three test supplements: amino acid mixture 0.76 g/day; amino acid mixture 1.52 g/day; or amino acid mixture 1.52 g/day coadministered with conjugated linoleic acid 1.6 g/day and exercises for a period of 12 weeks The results suggest that ingestion of these supplements might enhance the fat-burning effects of exercise. WANDERS et al, 2010 [ 68 ] Sixty-one healthy women and men Double-blind, placebo controlled study It was provided either by oleic acid, by industrial trans fatty acids or by a mixture of 80 % 9- cis , 11- trans and 20 % 10- trans , 12- cis CLA.…”

Section: Evidences From Human Studiesmentioning

confidence: 99%

A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism

Lehnen

Silva

Camacho

et al. 2015

Journal of the International Society of Sports Nutrition

130

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Conjugated linoleic acid (CLA) is highly found in fats from ruminants and it appears to favorably modify the body composition and cardiometabolic risk factors. The capacity of CLA to reduce the body fat levels as well as its benefic actions on glycemic profile, atherosclerosis and cancer has already been proved in experimental models. Furthermore, CLA supplementation may modulate the immune function, help re-synthetize of glycogen and potentiate the bone mineralization. CLA supplementation also could increase the lipolysis and reduce the accumulation of fatty acids on the adipose tissue; the putative mechanisms involved may be its action in reducing the lipase lipoprotein activity and to increase the carnitine-palmitoil-transferase-1 (CAT-1) activity, its interaction with PPARγ, and to raise the expression of UCP-1. Although studies made in human have shown some benefits of CLA supplementation as the weight loss, the results are still discordant. Moreover, some have shown adverse effects, such as negative effects on glucose metabolism and lipid profile. The purpose of this article is to review the available data regarding the benefits of CLA on the energetic metabolism and body composition, emphasizing action mechanisms.

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“…The additive effects or synergistic impact of eating routines and exercise have recently been thoroughly studied. 4 , 5 Our research group has considered the impact of amino acid supplementation, in combination with exercise, on fat oxidation for over two decades. 6 – 15 Recently, we concentrated on the amino acids arginine, alanine, and phenylalanine, which are involved in glucagon synthesis and secretion when delivered acutely.…”

Section: Introductionmentioning

confidence: 99%

Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults

Ueda¹,

Sasai

Tsujimoto

et al. 2018

DMSO

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PurposeThe purpose of this study was to test the efficacy of arginine, alanine, and phenylalanine mixture (A-mix) ingestion at 1,500 mg/day in combination with the promotion of physical activity for abdominal fat reduction in overweight adults.MethodsA placebo-controlled, double-blind, parallel-group, randomized trial for 12 weeks combined with a 4-week follow-up period was conducted at a single center in Minato-ku, Tokyo, Japan, between December 2016 and May 2017. Data were analyzed between June and August 2017. The study participants were 200 overweight adults within the age range of 20–64 years. The participants were randomly assigned to the A-mix group (n=100) or a placebo group (n=100) and were administered 500 mL of test beverage containing 1,500 or 0 mg of A-mix, respectively, for 12 weeks. All participants maintained a physically active lifestyle between week 0 and week 12 through monthly sessions of physical activity. The primary outcomes were the 12-week changes in the abdominal total, subcutaneous, and visceral fat areas, as assessed by computed tomography.ResultsOf the 200 enrolled participants, 199 (99%) accomplished the 12-week intervention and 4-week follow-up period. The per-protocol-based analysis for 194 participants demonstrated that the abdominal total fat area decreased significantly in the A-mix group compared with that in the placebo group (difference, 10.0 cm2; 95% confidence interval [CI]: 0.4–19.6 cm2; P=0.041). Comparable outcomes were obtained for the abdominal subcutaneous fat area (difference, 7.4 cm2; 95% CI: 0.1–14.7 cm2; P=0.047). No study-related unfavorable events occurred.ConclusionA-mix supplementation in combination with physical activity promotion facilitated abdominal fat reduction in overweight adults.

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Evaluation of the Antiobesity Effects of an Amino Acid Mixture and Conjugated Linoleic Acid on Exercising Healthy Overweight Humans: A Randomized, Double-blind, Placebo-controlled Trial

Cited by 21 publications

References 23 publications

Evaluation of anti-obesity potential of aqueous extract of Achyranthes aspera Linn. in high fat diet induced obese rats

Evaluation of anti-obesity potential of aqueous extract of Achyranthes aspera Linn. in high fat diet induced obese rats

A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism

Randomized trial of amino acid mixture combined with physical activity promotion for abdominal fat reduction in overweight adults

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