A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism

Lehnen, Tatiana Ederich; Silva, Marcondes Ramos da; Camacho, Augusto dos Santos; Marcadenti, Aline; Lehnen, Alexandre Machado

doi:10.1186/s12970-015-0097-4

Cited by 131 publications

(95 citation statements)

References 63 publications

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“…The elevated basal insulin concentrations in the present study support earlier findings of Tsao et al. () and Lehnen, da Silva, Camacho, Marcadenti, and Lehnen (), who observed higher glycogen resynthesis in skeletal muscles by an increased glucose uptake via the insulin‐sensitive glucose transporter GLUT4 (Gross, van Dorland, Wellnitz, & Bruckmaier, ). Hints for positive impacts of CLA on the immune system were found in rats, chicken, mice (Cook, Miller, Park, & Pariza, ; Ntambi, Choi, Park, Peters, & Pariza, ) and humans (Albers et al., ).…”

Section: Discussionsupporting

confidence: 92%

Inflammatory and metabolic responses to an intramammary lipopolysaccharide challenge in early lactating cows supplemented with conjugated linoleic acid

Gross

Grossen-Rösti

Héritier

et al. 2017

Animal Physiology Nutrition

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Supplementation of dairy cows with trans-10, cis-12 conjugated linoleic acid (CLA) allows nutrient repartitioning despite an energy deficiency in early lactation, which might be a benefit for the immune system, too. In this study, we investigated potential nutrient sparing effects of CLA in early lactating cows with low plasma glucose concentrations exposed to an intramammary lipopolysaccharide (LPS) challenge. Fifteen multiparous Holstein cows were exposed to an intramammary LPS challenge in week 4 p.p. Eight cows (CLA) were supplemented daily with 70 g of lipid-encapsulated CLA (6.8 g trans-10, cis-12 and 6.6 g of the cis-9, trans-11 CLA isomer; CLA) and seven cows with 56 g of control fat (CON). Blood samples were obtained every 30 min along with rectal temperature, heart and respiratory rate, and milk samples were taken hourly until 10 hr after the LPS application. Plasma was analysed for concentrations of glucose, free fatty acids, beta-hydroxybutyrate (BHB), cortisol, insulin and glucagon. In milk, somatic cell count and activity of lactate dehydrogenase were determined. Initial plasma glucose concentration was lower in CLA than in CON. During the immunostimulation, CLA had higher glucose concentrations than CON, and BHB decreased distinctly in CLA, whereas CON cows maintained BHB concentration at a lower level. Body temperature in CLA increased earlier, the difference between peak and basal temperature was higher, and the decline thereafter occurred earlier. In conclusion, CLA supplementation of early lactating cows exposed to an intramammary LPS challenge affected local and systemic immune responses. We assume that CLA supplementation triggered glycogen storage. Cows supplemented with CLA provided more glucose and preferentially used BHB as an energy source during the immune response. The more intense metabolic and more concentrated endocrine responses support an immunomodulatory effect of CLA supplementation.

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Section: Discussionsupporting

confidence: 92%

Inflammatory and metabolic responses to an intramammary lipopolysaccharide challenge in early lactating cows supplemented with conjugated linoleic acid

Gross

Grossen-Rösti

Héritier

et al. 2017

Animal Physiology Nutrition

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“…It has become a subject of interest as a supplement for human nutrition because of its biological activities. The capacity of CLA to reduce the body fat levels as well as its benefic actions on glycemic profile, atherosclerosis and cancer has already been proved in experimental models [25,30]. It has been considered an anti-obesity agent and can be useful in the weight reduction process [11].…”

Section: Fatty Acids Profile Of Yeasts After Culturing In Medium Withmentioning

confidence: 99%

Evaluation of lipid biosynthesis ability by Rhodotorula and Sporobolomyces strains in medium with glycerol

Gientka

Gadaszewska

Błażejak

et al. 2016

Eur Food Res Technol

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“…ADMA concentration is positively associated with low-density lipoprotein cholesterol concentration (28). Because CLA supplementation results in changes in the blood lipid profile (2, 29), we hypothesized that CLA may influence ADMA levels beneficially. However, we did not confirm this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Twelve-week-conjugated linoleic acid supplementation has no effects on the selected markers of atherosclerosis in obese and overweight women

Duś-Żuchowska

Mądry

Krzyżanowska

et al. 2016

Food & Nutrition Research

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BackgroundThe antiatherogenic effect of conjugated linoleic acid (CLA) has been demonstrated in animal models. Although there are plenty of in vitro studies that suggest the profitable properties of CLA, the results in humans remain inconsistent.ObjectiveIn this study, we assessed the impact of CLA supplementation on the levels of atherosclerosis markers – high-sensitivity C-reactive protein (hs-CRP) and asymmetrical dimethylarginine (ADMA).DesignSeventy-four adult female subjects with body mass index ≥25 kg/m2 were enrolled in the double-blind, placebo-controlled nutritional intervention. The study participants were randomly assigned to receive 3 g/day CLA or placebo (sunflower oil) for 12 weeks. In all subjects, we measured hs-CRP and ADMA concentrations by using enzyme-linked immunosorbent assay.ResultsNo significant differences were found in hs-CRP and ADMA levels before and after nutritional intervention between both groups. The changes in hs-CRP and ADMA concentration values (Δhs-CRP; ΔADMA median [interquartile range]) did not differ between subjects from the placebo (−0.1 [−0.8 to 0.3]; −0.02 [−0.12 to 0.14]) and CLA (0.2 [−0.7 to 0.9]; 0.04 [−0.14 to 0.13]) groups. The incidence of reduction of hs-CRP or ADMA concentration was not different in subjects of the CLA group compared to those of the placebo group (41.9% vs. 50%, relative risk [RR]=0.8387, 95% confidence interval [CI]=0.4887–1.4493, p=0.5232 and 61.3% vs. 56.2%, RR=1.0896, 95% CI=0.7200–1.6589, p=0.6847, respectively).ConclusionTwelve weeks of CLA supplementation had no effect on selected markers of atherosclerosis in obese and overweight women.

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A review on effects of conjugated linoleic fatty acid (CLA) upon body composition and energetic metabolism

Cited by 131 publications

References 63 publications

Inflammatory and metabolic responses to an intramammary lipopolysaccharide challenge in early lactating cows supplemented with conjugated linoleic acid

Inflammatory and metabolic responses to an intramammary lipopolysaccharide challenge in early lactating cows supplemented with conjugated linoleic acid

Evaluation of lipid biosynthesis ability by Rhodotorula and Sporobolomyces strains in medium with glycerol

Twelve-week-conjugated linoleic acid supplementation has no effects on the selected markers of atherosclerosis in obese and overweight women

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