This single-centre, randomized, doubleblind, placebo-controlled trial investigated the effects of administering a mixture of four amino acids (lysine, proline, alanine and arginine) with or without conjugated linoleic acid to healthy overweight humans before and after exercising. Fortyone healthy subjects (body mass index ≥ 23 to < 30 kg/m 2 ) completed the study following randomization to receive either placebo or one of three test supplements: amino acid mixture 0.76 g/day; amino acid mixture 1.52 g/day; or amino acid mixture 1.52 g/day coadministered with conjugated linoleic acid 1.6 g/day. Each of the study treatments was administered 30 min before and immediately after a period of daily exercise, which was delivered by an exercise expert, for a period of 12 weeks. When compared with the placebo group, several indicators, such as waist and hip circumferences, were found to have significantly decreased in the test supplement groups compared with the placebo. These results suggest that ingestion of these supplements might enhance the fat-burning effects of exercise.
Funding Acknowledgements Type of funding sources: None. Background Catheter ablation for persistent atrial fibrillation (AF) in patients with heart failure is known to improve heart failure. However, there were few reports comparing the outcomes of catheter ablation for patients with heart failure with reduced ejection fraction (HFpEF) and heart failure with preserved ejection fraction (HFpEF). Method Patients with E/e’ > 15 and EF > 50% on preoperative echocardiography were defined HFpEF, and those with EF < 40% were defined as HFrEF. We compared ablation outcomes and postoperative BNP changes between patients with HFpEF (HFpEF-group) and HFrEF (HFrEF-group). Result There were 166 cases of HFpEF-group and 177 of HFrEF-group among the cases with catheter ablation for persistent AF in our hospital from 2013 to 2021. The median preoperative BNP was 190.7 pg/ml in HFrEF-group and 144.3 in HFpEF-group, significantly higher in HFrEF-group (P=0.001). After a mean follow-up of 37.2 months, maintenance of sinus rhythm without any antiarrhythmic drugs was significantly better in the HFrEF-group (64.4% and 53.6%, p=0.048). After one year of ablation, median BNP was significantly higher in HFpEF-group (HFpEF: 37.5 pg/ml, HFrEF: 22.0 pg/ml; p=0.017), contrary to before ablation. Conclusion Catheter ablation for persistent AF with HFrEF showed better ablation outcomes and improved BNP levels compared to those with HFpEF.
Funding Acknowledgements Type of funding sources: None. Backgrounds Catheter ablation for paroxysmal supraventricular tachycardia (PSVT) is curative treatment. However, diagnosis of atrial tachycardia (AT) distinguishing from other PSVTs are often challenging, especially when the tachycardia terminates after pacing or does not sustain long enough for diagnostic maneuvers. We sought a new method for diagnosis of AT. Methods One-hundred and thirty-four PSVTs including 20 ATs, 84 atrioventricular nodal reentrant tachycardias (AVNRTs) and 30 orthodromic reciprocating tachycardias (ORTs) were studied. Single atrial stimulation was started at intervals of 20ms shorter than the tachycardia cycle length during the tachycardia and coupling interval was shortened by 10ms. The pacing was performed from the proximal coronary sinus, which was not the earliest excitatory site, and pacing continued until the His potential was reset or the tachycardia terminated. The incidence of tachycardia resetting and the patterns of tachycardia termination were examined. Results Resetting of His was obtained in all AT patients without tachycardia termination. All ATs were not reset despite of His resetting.(Figure 1A) In AVNRTs or ORTs patients, 31 tachycardias (27%) were terminated with AH block before His resetting. In the 83 AVNRTs or ORTs, tachycardia was also reset when His was reset simultaneously.(Figure 1B) When tachycardia resetting was not observed despite His resetting, the diagnostic power of AT was 100% in sensitivity, specificity, positive predictive value, and negative predictive value. All cases which PSVTs were terminated before His resetting were AVNRTs or ORTs.(Figure 2) Conclusions A single atrial programmed stimulation resetting His during tachycardia was effective for differentiating PSVT even in cases that tachycardia terminates by the pacing.
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