Diet Quality and Its Relationship with Antioxidant Status in Patients with Rheumatoid Arthritis

Prescha, Anna; Zabłocka‐Słowińska, Katarzyna; Płaczkowska, Sylwia; Gorczyca, Damian; Łuczak, Anna; Majewska, Marcelina; Grajeta, Halina

doi:10.1155/2018/8506343

Cited by 11 publications

(13 citation statements)

References 46 publications

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“…Given the absence of studies focused on investigating the association between diet quality and oxidative stress in women with breast cancer, the current study used results of the correlation of vegetable intake and saturated fat energy rate to oxidative stress biomarkers (Total Antioxidant Status)—i.e., 0.42 and −0.38, respectively—recorded for patients with rheumatoid arthritis [ 40 ]. Type I error of 0.05 and study power of 80% were taken into consideration for sample calculation, based on the formula described by Bowner et al [ 41 ].…”

Section: Methodsmentioning

confidence: 99%

Diet Quality Is Associated with Serum Antioxidant Capacity in Women with Breast Cancer: A Cross Sectional Study

et al. 2020

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Oxidative stress produced by adjuvant treatments is associated with cell injury; however, a healthy diet can help mitigate it. The aim of this study is to investigate the association between diet quality and oxidative stress parameters in women subjected to adjuvant treatment for breast cancer. The sample comprised 70 women. Oxidative stress biomarkers and diet quality parameters based on the Brazilian Healthy Eating Index—Revised (BHEI-R)—were evaluated at baseline (p0) and after adjuvant treatment (p1). Ferric reducing antioxidant potential (FRAP) was associated with diet quality at p0. BHEI-R scores were not different between p0 and p1; however, scores from total vegetables, total fruits, milk and dairy products, and meat, eggs and legumes were lower during treatment. On the other hand, lower sodium and saturated fat intake observed at p1 counterbalanced the BHEI-R score. Oxidative stress parameters have increased at p1, but they were not associated with diet quality; thus, changes in component intake were not enough to promote changes in oxidative stress during treatment. It appears that diet can enhance patients’ antioxidant defense before treatment, which could lead to better outcomes in the long term. Further investigations may help to clarify the association between diet and oxidative stress in women with breast cancer.

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Section: Methodsmentioning

confidence: 99%

Diet Quality Is Associated with Serum Antioxidant Capacity in Women with Breast Cancer: A Cross Sectional Study

et al. 2020

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“…Our previous study showed that the intake of some essential nutrients, such as polyunsaturated fatty acids, vitamin E, B6, and calcium correlated with higher serum antiradical activity in RA patients; moreover, this antioxidant potential was beneficially linked with disease duration and severity. 18 Silicon also seems to be involved in redox balance and inflammation, though these observations originate from animal models and the cell cultures underwent toxic, metabolic, or immune challenges. [7][8][9][10] The effects of dietary silicon on the development, progress, and severity of autoimmune diseases have not yet been studied.…”

Section: Discussionmentioning

confidence: 99%

“…Silicon sources in the diets of both groups greatly reflected the dietary habits of the adult Polish population, as recently published in the National MultiCenter Health Survey (WOBASZ II, 2013-14), 27,28 and in our previous study concerning the diet quality of RA patients vs controls. 18 These habits include consuming a high proportion of white bread to total cereal products, tea and coffee comprising much of the non-alcoholic beverages, and fruit and vegetable consumption which is lower than recommended.…”

Section: Discussionmentioning

confidence: 99%

“…35 In our previous study, systemic antioxidant capacity was shown to decrease in RA patients, as disease activity and lenght of time from disease onset increased. 18 With regard to this observation and the suggested contribution of silicon to antioxidant status in RA, we evaluated the association of dietary and plasma silicon with the clinical indices used to monitor RA activity and duration. A negative correlation between plasma silicon and the number of swollen joints was revealed among female RA patients; moreover, a non-significant positive trend was also noted for disease duration among non-smoking subjects (r = 0.19, p = 0.068).…”

Section: Discussionmentioning

confidence: 99%

“…Dietary intake in the 2 groups was assessed by dietary recall from the last 3 days before the interview. 18 Long--term silicon intake was assessed using a questionnaire on dietary habits developed by the Department of Food Science and Dietetics at the Wroclaw Medical University. 19 The questionnaire consists of 106 questions concerning the consumption of food groups and individual foods within those groups, calculated in portions per unit of time.…”

Section: Dietary Intake Assessmentmentioning

confidence: 99%

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Silicon intake and plasma level and their relationships with systemic redox and inflammatory markers in rheumatoid arthritis patients

Prescha¹,

Zabłocka‐Słowińska²,

Płaczkowska³

et al. 2019

Adv Clin Exp Med

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H. Silicon intake and plasma level and their relationships with systemic redox and inflammatory markers in rheumatoid arthritis patients. AbstractBackground. The nutritional significance of silicon for the human body is highlighted by a continually growing body of evidence. In conditions of excessive reactive oxygen species and upregulated immune response, silicon has been observed to provide benefits, but its role in redox and inflammatory status has not yet been examined in rheumatoid arthritis (RA).Objectives. The aim of this study was to assess the relationship of silicon intake and plasma level to systemic indices of redox status and inflammation in patients with RA.Material and methods. Silicon intake and plasma levels were measured in 115 RA subjects and 129 control subjects. Serum antioxidant and oxidant levels, antioxidant enzyme activity, and albumin, uric acid, TBARS, hs-CRP, and IL-6 levels were measured and compared to the intake and plasma levels of silicon.Results. Silicon intake and plasma silicon levels were higher in RA subjects than in the controls. In the RA group, a generally favorable correlation to redox and inflammatory markers was found for silicon in diet and in plasma; however, albumin level, smoking status, and gender interfered with these results. In the control subjects, a significant relationship was observed only between plasma silicon and non-enzymatic markers of redox status. Conclusions.There are suggestions of silicon's involvement in managing redox and inflammatory status in RA, though further studies are warranted.

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Trivalent chromium supplementation ameliorates adjuvant induced rheumatoid arthritis through up-regulation of FOXP3 and decrease in synovial Cathepsin G expression

et al. 2022

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Background Rheumatoid arthritis (RA) is a known debilitating autoimmune disease. Immune-suppressants that are used for disease treatment have serious side effects, therefore, trivalent chromium (Cr (III)); which has shown evidence of its influences on some inflammatory pathways and cytokines; was used in this study for the first time to be assessed for its therapeutic effect in RA rat model and was compared to prednisolone in a trial to find a treatment with lesser side effects. Methods Adult male albino rats were randomly divided into four groups: normal, untreated RA, prednisolone treated RA (1.25 mg/kg/day) and Cr (III) treated RA groups (80 μg/kg/day), induction of RA was done by subcutaneous complete Freund adjuvant injection. Study duration was 4 weeks throughout which arthritis scoring and weight measurement were pursued. Histopathological examination and immunohistochemical FOXP3 assessment were done for joint biopsies. Serum inflammatory markers (interleukin 17, interleukin 10, CRP) and synovial erosive arthritis marker (Cathepsin G) were measured. HDL and non-HDL cholesterol were estimated as well. Results Cr (III) treatment showed marked clinical and histopathological improvement, also astonishing anti-inflammatory effects (increase in FOXP3 expression and interleukin 10, with decrease in interleukin 17, CRP and synovial Cathepsin G) to the extent that Cr (III) effects on inflammation abolishment were comparable to that of prednisolone and even better at some aspects. Moreover, Cr (III) was protective from side effects, i.e., weight gain and dyslipidemia that were seen with prednisolone treatment. Conclusions Cr (III) is promising in treating RA and it lacks some side effects of accustomed immune-modulatory agents including prednisolone. Further experimental studies and clinical trials should be held to see the efficacy of Cr (III) in different doses and to assess its long term side effects when used for rheumatoid arthritis and other autoimmune diseases treatment.

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Diet Quality and Its Relationship with Antioxidant Status in Patients with Rheumatoid Arthritis

Cited by 11 publications

References 46 publications

Diet Quality Is Associated with Serum Antioxidant Capacity in Women with Breast Cancer: A Cross Sectional Study

Diet Quality Is Associated with Serum Antioxidant Capacity in Women with Breast Cancer: A Cross Sectional Study

Silicon intake and plasma level and their relationships with systemic redox and inflammatory markers in rheumatoid arthritis patients

Trivalent chromium supplementation ameliorates adjuvant induced rheumatoid arthritis through up-regulation of FOXP3 and decrease in synovial Cathepsin G expression

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