Diet Quality Is Associated with Serum Antioxidant Capacity in Women with Breast Cancer: A Cross Sectional Study

Reitz, Luiza Kuhnen; Baptista, Sheyla de L; Santos, E.; Hinnig, Patrícia F; Rockenbach, Gabriele; Vieira, Francilene Gracieli Kunradi; Assis, Maria Alice Altenburg de; Silva, Edson Lourenço da; Boaventura, Brunna Cristina Bremer; Pietro, Patrícia Faria Di

doi:10.3390/nu13010115

Cited by 6 publications

(5 citation statements)

References 57 publications

(26 reference statements)

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“…Additionally, Yeon et al [65] found an inverse association between vitamin A and β-carotene intake and 8-OH-dG levels in women with breast cancer. Contributing to the present results, we showed in a recent publication that diet quality score, which includes eating fruits and vegetables according to the Brazilian recommendation for a healthy diet, is positively associated with serum FRAP levels in women diagnosed with breast cancer [55].…”

Section: Discussionsupporting

confidence: 79%

“…It appears that these results indicate that women showing highest DaC before beginning adjuvant treatment and during it exhibit some kind of protection against the aggravation of oxidative stress. This is an expected consequence in women submitted to adjuvant treatment for breast cancer [55,56], since the aim of it is killing breast cancer cells by exacerbating oxidative stress [57,58].…”

Section: Discussionmentioning

confidence: 99%

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Dietary Antioxidant Capacity Promotes a Protective Effect against Exacerbated Oxidative Stress in Women Undergoing Adjuvant Treatment for Breast Cancer in a Prospective Study

et al. 2021

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Breast cancer (Bca) is the most common type of cancer among women worldwide, and oxidative stress caused by adjuvant treatment may be decreased by antioxidant intake. The aim of this study is to investigate the associations between Dietary antioxidant Capacity (DaC) and oxidation and antioxidant biomarkers in women undergoing adjuvant treatment (AT) for Bca. This prospective study had a sample of 70 women (52.2 ± 10.7 y). DaC (mmol/g) was calculated using nutritional data obtained from a Food Frequency Questionnaire, and blood was collected to measure the oxidation and antioxidant biomarkers at baseline (T0), and after AT (T1). Carbonylated protein levels were inversely associated with DaC at T1 (p = 0.004); women showed an increased risk of having increment on lipid hydroperoxides and thiobarbituric acid reactive substances (TBARS), and decrement on ferric reducing antioxidant power (FRAP) and reduced glutathione after AT, in response to lowered DaC (p < 0.05). Carbonylated proteins, TBARS and FRAP levels remained stable between the periods for women at the 3rd DaC tertile at T1, differentiating them from those at the 1st tertile, who showed negative changes in these biomarkers (p < 0.04). DaC may be beneficial for women undergoing AT for Bca, since it promoted a reduction in oxidative stress.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Dietary Antioxidant Capacity Promotes a Protective Effect against Exacerbated Oxidative Stress in Women Undergoing Adjuvant Treatment for Breast Cancer in a Prospective Study

et al. 2021

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“…In a previous study from the same original sample, we have shown that a higher diet quality score was associated with higher ferric antioxidant power (FRAP), a biomarker of antioxidant defense in serum, before adjuvant treatment for breast cancer began [ 11 ]. Herein, the protective effect of diet quality before the beginning of adjuvant chemotherapy on the chance of developing food aversion may be linked to increased serum antioxidant defense.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, one of the main causes of food aversions in response to adjuvant chemotherapy is increased oxidative stress [ 10 ]. We have already demonstrated that diet quality and a diet rich in antioxidants can help mitigate the excess production of reactive oxygen species [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Diet Quality Influences the Occurrence of Food Aversions in Women Undergoing Adjuvant Chemotherapy for Breast Cancer

Reitz

Schroeder

Raick

et al. 2022

IJERPH

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Food aversions in women undergoing adjuvant chemotherapy for breast cancer may be linked to oxidative stress and gastrointestinal consequences underlying it, and diet possibly plays a role in this association. This follow-up study included 73 women with breast cancer treated in Florianopolis City, Brazil. Dietary antioxidant capacity–DaC (mmol/d), diet quality–Brazilian Healthy Eating Index Revised (BHEI-R score), and oxidative stress biomarkers were accessed before the treatment, and women were asked if they developed food aversions during adjuvant chemotherapy. Red meat was the main aversion-causing food reported (37.9%, n = 9). There was no difference in DaC, BHEI-R score, or oxidative stress biomarkers between women with no food aversion occurrence and those showing food aversions. A logistic regression adjusted model showed that women exhibiting higher BHEI-R scores were 1.08 times more likely to not develop food aversions during adjuvant chemotherapy (p = 0.041). In summary, this innovative investigation showed that diet quality before adjuvant chemotherapy may influence the non-occurrence of food aversion. Considering this, the result opens new areas for early nutritional interventions, focusing on reducing the occurrence of food aversions and consequently benefiting women with breast cancer by having better outcomes in oncologic treatment.

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“…However, a large number of clinical practices have shown that these treatment methods encounter the problems of primary and secondary drug resistance, which has become a major treatment obstacle that is difficult to avoid in clinical practice [ 1 , 2 ]. For example, luminal A and luminal B breast cancers account for 70% to 80% of all types of breast cancer, respectively; approximately 70% of patients had effective initial drug treatment; and approximately 30% of patients had resistance to primary endocrine therapy [ 3 ]. Nearly 50% of HER2-amplified breast cancers are resistant to herceptin at the beginning, and secondary resistance appears approximately one year after treatment [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

CircINTS4 Facilitates Chemoresistance of TNBC by Competitively Binding miR-129-5p/POM121 Axis

Tang

Zhou

Yang

et al. 2022

Journal of Oncology

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Objectives. To detect the expression of circular RNA (circRNA) circINTS4 in triple-negative breast cancer (TNBC) and to analyze the relationship between the expression of circRNA circINTS4 and the clinicopathological characteristics and chemotherapy resistance of patients with TNBC. Methods. Bioinformatics was used to predict that circINTS4 and POM121 could bind to miR-129-5p, and dual luciferase reporter genes proved that circINTS4 could bind to miR-129-5p and miR-129-5p could bind to POM121. RNA immunoprecipitation (RIP) and RNA pull-down experiments confirmed that circINTS4 binds to miR-129-5p. The correlation among circINTS4, miR-129-5p, and POM121 was detected by qRT-PCR. Results. In ADR-resistant TNB cells, circINTS4 was significantly up-regulated, miR-129-5p was down-regulated, and POM121 protein expression was significantly up-regulated. Experimental results showed that circINTS4 knockdown inhibited proliferation, migration, invasion, and autophagy. Knocking down miR-129-5p or overexpression of POM121 reversed the inhibitory effect of sh-circints4 on the development of ADR-resistant TNBC cells. In addition, CIRCINTS4 regulates POM121 expression by sponge-adsorbed miR-129-5p. CIRCINTS4 knockdown prevents ADR-resistant tumor growth by regulating the miR-129-5p/POM121 axis in vivo. Conclusions. CircRNA circINTS4 may act as the ceRNA of miR-129-5p to regulate the expression of target gene POM121, thereby promoting the progress of TNBC molecular mechanism and providing scientific basis for circINTS4 as a new molecular target for clinical diagnosis and drug resistance therapy of TNBC.

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Diet Quality Is Associated with Serum Antioxidant Capacity in Women with Breast Cancer: A Cross Sectional Study

Cited by 6 publications

References 57 publications

Dietary Antioxidant Capacity Promotes a Protective Effect against Exacerbated Oxidative Stress in Women Undergoing Adjuvant Treatment for Breast Cancer in a Prospective Study

Dietary Antioxidant Capacity Promotes a Protective Effect against Exacerbated Oxidative Stress in Women Undergoing Adjuvant Treatment for Breast Cancer in a Prospective Study

Diet Quality Influences the Occurrence of Food Aversions in Women Undergoing Adjuvant Chemotherapy for Breast Cancer

CircINTS4 Facilitates Chemoresistance of TNBC by Competitively Binding miR-129-5p/POM121 Axis

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