Silicon intake and plasma level and their relationships with systemic redox and inflammatory markers in rheumatoid arthritis patients

Abstract

H. Silicon intake and plasma level and their relationships with systemic redox and inflammatory markers in rheumatoid arthritis patients. AbstractBackground. The nutritional significance of silicon for the human body is highlighted by a continually growing body of evidence. In conditions of excessive reactive oxygen species and upregulated immune response, silicon has been observed to provide benefits, but its role in redox and inflammatory status has not yet been examined in rheumatoid arthritis (RA).Objectives. The aim of this study was to assess the relationship of silicon intake and plasma level to systemic indices of redox status and inflammation in patients with RA.Material and methods. Silicon intake and plasma levels were measured in 115 RA subjects and 129 control subjects. Serum antioxidant and oxidant levels, antioxidant enzyme activity, and albumin, uric acid, TBARS, hs-CRP, and IL-6 levels were measured and compared to the intake and plasma levels of silicon.Results. Silicon intake and plasma silicon levels were higher in RA subjects than in the controls. In the RA group, a generally favorable correlation to redox and inflammatory markers was found for silicon in diet and in plasma; however, albumin level, smoking status, and gender interfered with these results. In the control subjects, a significant relationship was observed only between plasma silicon and non-enzymatic markers of redox status. Conclusions.There are suggestions of silicon's involvement in managing redox and inflammatory status in RA, though further studies are warranted.

Dietary Habits and Nutrition in Rheumatoid Arthritis: Can Diet Influence Disease Development and Clinical Manifestations?

“…A study evaluating the relationship between plasma silicon levels, redox status (total antioxidant status) and inflammatory markers (CRP, IL-6) in RA, reported that patients affected by RA presented elevated plasma silicon levels compared to controls. No correlation between plasma silicon and dietary silicon level was observed, although in RA patients a negative correlation between silicon intake and IL-6 and total oxidant status was found [175]. In a recent randomized, double-blind, placebo-controlled clinical trial, active RA patients received 1500 mg ginger powder (or placebo) daily for 12 weeks.…”

Dietary Silicon and Its Impact on Plasma Silicon Levels in the Polish Population

“…This association was not observed for hot beverages (coffee and tea), which may be related to coffee and tea polyphenols affecting the availability of minerals [25]. However, in our recent study we noticed a positive association between plasma silicon and tea and coffee consumption in rheumatoid arthritis patients [8]. As the body silicon status in rheumatoid arthritis seems to be affected, other factors related to the disease may interfere with the associations found.…”

“…The direct measurement of silicon in plasma was performed by GF-AAS (PinAAcle 900, Perkin Elmer, USA) using the method of standard addition calibration described elsewhere [8]. The operating conditions and instrumental parameters for silicon measurement are summarized in Supplementary Table S1.…”

“…However, only a few reports have been published on silicon concentrations in the blood, and the values reported for fasting serum concentration in healthy adult subjects have ranged from 100 to 310 μg/L. Moreover, the relationship between silicon intake from a common daily diet and silicon blood level has so far been scarcely elucidated [8]. This results partly from the limited number of studies on the silicon content in foods and its intake in the diet.…”

“…The results of our recently published study have indicated that diet composition might be related to plasma silicon level in healthy Polish subjects [8], however no thorough analysis of this relationship has been carried out with regard to bioavailable silicon intake. The aim of this study was, therefore, to assess the relationship between plasma silicon levels and total and bioavailable silicon intake from a typical diet, with respect to the contribution of food groups into the total dietary silicon, in a healthy adult Polish population.…”