Die extragenitalen heterotopen Epithelwucherungen vom Bau der Uterusschleimhaut

Lauche, A.

doi:10.1007/bf01961722

Cited by 59 publications

(4 citation statements)

References 25 publications

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“…Other hypotheses are those of metaplastic processes, as coelomic metaplasia [9,[124][125][126], or metaplasia of the peritoneal or ovarian tissue [127,128], or metaplasia of the peritoneal serosa cuff initiated by inflammation [9,129] or by hormonal stimulation [130]. The possibility of metaplasia development, by differentiation of mesenchymal cells (omnipotent blastema) activated by substances released by degenerating endometrium eliminated into the abdominal cavity, has been also proposed [131,132].…”

Section: Short Overview -Historical Hallmarksmentioning

confidence: 99%

Endometriosis — insights into a multifaceted entity

Amălinei

Păvăleanu

Lozneanu

et al. 2018

Folia Histochem Cytobiol.

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Firstly described at the end of nineteenth century, endometriosis remains an enigmatic disease, from etio-pathogenesis to specific markers of diagnosis and its ability to associate with malignancies. Our review has been designed from a historical perspective and steps up to an updated understanding of the disease, facilitated by relatively recent molecular and genetic progresses. Although the histopathological diagnosis is relatively simple, the therapy is difficult or ineffective. Experimental models have been extremely useful as they reproduce the human disease and allow the testing of different potential modulators or treatment options. Due to molecular resemblance to carcinogenesis, applications of anti-cancer agents are currently under scrutiny. The desired goal of an efficient therapy against symptomatic disease, along with associated infertility and malignancies, needs a deeper insight into the complex mechanisms involved in endometriosis initiation, development, and progres-sion. Current trends in genomic and proteomic approaches are useful for a more accurate classification and for the identification of new therapeutic targets.

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Section: Short Overview -Historical Hallmarksmentioning

confidence: 99%

Endometriosis — insights into a multifaceted entity

Amălinei

Păvăleanu

Lozneanu

et al. 2018

Folia Histochem Cytobiol.

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“…Endometriosis was supposed only to develop where peritoneum was found. According to this theory that was already suggested by Iwanoff (1898) and later was followed by Lauche (1923) and Meyer (1924), the histogenesis of endometriosis is explained by metaplasia of the original coelomic membrane. These metaplastic changes could occur secondary to inflammatory processes or hormonal influences (Meyer, 1919;Novak, 1931).…”

Section: In-situ Developmentmentioning

confidence: 94%

“…The oldest concept, that of in-situ develop- Table I. Theories on the pathogenesis of endometriosis (modified from Hingst, 1926 andRidley, 1968) In-situ development a. Germinal epithelium of the ovary (Waldeyer, 1870) b. Embryonic cell rests Mesonephric (Wolffian knob, Wolffian duct) (Von Recklinghausen, 1895, Breus, 1894 Paramesonephric (Mullerian ducts) (Cullen, 1896, Russell, 1899 c. Coelomic metaplasia (Iwanoff, 1898, Meyer, 1903, Lauche, 1923 d. Metaplasia by inflammation (Hueter, 1918, Meyer, 1919, Tobler, 1923 e. Metaplasia by hormonal stimulation (Novak, 1931) f. Metaplasia by induction (omnipotent blastema) (Levander, 1941, Merril, 1966 g. Secondary Mullerian system (Lauchlan, 1972) Transplantation a. Implantation, retrograde menstruation (Sampson, 1921) b. Implantation, mechanical transplantation (Greenhill, 1942) c. Benign lymphogenous metastasis (hystero-adenosis metastatica) (Halban, 1924/1925, Javert, 1949 Combination of in-situ development and endometrial transplantation and implantation ment, is that endometriosis develops on the spot where it is found. Development may occur from the remnants of the Wolffian ducts or the Mullerian ducts, or alternatively from metaplasia of the peritoneal or ovarian tissue (Ridley, 1968;Lauchlan, 1972).…”

Section: Three Conceptsmentioning

confidence: 99%

“…These findings rendered a purely embryonic derivation too restrictive. Lauche (1923) was one of the first to explain the development of endometriosis from a single origin, no matter where it developed. He deduced a common origin for different spots of endometriosis from the strict resemblance in histological morphology of these lesions.…”

Section: In-situ Developmentmentioning

confidence: 99%

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Theories on the Pathogenesis of Endometriosis

Nap

2011

Endometriosis

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Although endometriosis has been known for over 100 years, its pathogenesis is still poorly understood. In this overview the literature regarding the pathogenesis of endometriosis is reviewed. The implantation or transplantation theory, that suggests implantation and subsequent growth of retrogradely shed viable endometrial cells, still remains the most widely accepted theory to explain the pathogenesis. The conditions that have to be met for the implantation theory are threefold: (i) retrograde menstruation has to occur; (ii) retrograde menstruation should contain viable endometrial cells; and (iii) adhesion to the peritoneum has to occur with subsequent implantation and proliferation. The scientific data to corroborate these conditions will be discussed. A short overview is given on cell adhesion molecules, in particular cadherins and integrins, the most important cell adhesion molecules involved in cell-cell adhesion and cell-extracellular matrix interaction. Special attention is given to the possible functional role of these cell adhesion molecules in the pathogenesis of endometriosis.

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Squamous metaplasia of the peritoneum

Crome

1950

J. Pathol.

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Die extragenitalen heterotopen Epithelwucherungen vom Bau der Uterusschleimhaut

Cited by 59 publications

References 25 publications

Endometriosis — insights into a multifaceted entity

Endometriosis — insights into a multifaceted entity

Theories on the Pathogenesis of Endometriosis

Squamous metaplasia of the peritoneum

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