Diagnostic value of procalcitonin levels as an early indicator of sepsis

Güven, Hakan; Altıntop, Levent; Baydın, Ahmet; Esen, Şaban; Aygün, Dursun; Hökelek, Murat; Doğanay, Zahide; Bek, Yüksel

doi:10.1053/ajem.2002.33005

Cited by 73 publications

(40 citation statements)

References 25 publications

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“…[21][22][23][24] Procalcitonin is an accurate biomarker for severe infection, 25,26 and for the diagnosis of bacterial sepsis and bacteraemia. 27 Procalcitonin concentration has also been used to guide the empirical antibiotic treatment of sepsis patients, 28 and, in accordance with our findings, is known to reflect the severity of infection as well as having prognostic implications for critically ill patients. 29 An advantage of procalcitonin over other biomarkers is that its production is not significantly affected by nonsteroidal or steroidal anti-inflammatory drugs.…”

Section: Discussionsupporting

confidence: 82%

Plasma concentrations of copeptin, C-reactive protein and procalcitonin are positively correlated with APACHE II scores in patients with sepsis

et al. 2015

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Objective: To evaluate the correlation between Acute Physiology and Chronic Health Evaluation II (APACHE II) score and plasma concentrations of copeptin, C-reactive protein (CRP) and procalcitonin in patients with sepsis. Methods: Patients with sepsis were prospectively enrolled. APACHE II scores were determined during the first 24 h after admission to the intensive care unit. Plasma copeptin, CRP and procalcitonin were quantified at admission, 24 h, 48 h, and 72 h. Survival at 28 days after admission was recorded. Results: APACHE II score was significantly positively correlated with plasma copeptin, CRP and procalcitonin concentrations. Survivors (n ¼ 15) had significantly lower APACHE II scores and copeptin, CRP and procalcitonin concentrations than nonsurvivors (n ¼ 26). APACHE II score, copeptin at 72 h, CRP at 48 h and procalcitonin at 24 h were independent risk factors for death. Conclusion: Plasma copeptin, CRP and procalcitonin concentrations were positively correlated with APACHE II score in patients with sepsis, and reflected disease severity.

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Section: Discussionsupporting

confidence: 82%

Plasma concentrations of copeptin, C-reactive protein and procalcitonin are positively correlated with APACHE II scores in patients with sepsis

et al. 2015

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“…The extent to which the PCT concentration is elevated could possibly be a useful laboratory tool for recognising sepsis patients, because 48% (n = 9) of the sepsis patients, even at the beginning of the illness, had concentrations > 2 ng/ml compared with the SIRS group in which only 14% (n = 9) had a concentration > 2 ng/ml. These results correspond with those of Hatherill et al (1999) and Rey et al (2007) (patients with localised bacterial infections and sepsis had PCT > 2 ng/ml) and with the data of Guven et al (2002) (significantly elevated changes in PCT in the early stages of disease were indicative of a greater probability that sepsis would develop). In conclusion, the method chosen for PCT detection in our study (for financial reasons) did not fulfill our expectations, the data were difficult to analyse statistically compared with similar data from other studies.…”

Section: Discussionsupporting

confidence: 88%

“…However, there do not have the specificity required to distinguish between viral and bacterial infections, autoimmune diseases, cancer and trauma (Ballou and Kushner, 1992). Later the calcitonin prohormone, procalcitonin (PCT) was proposed as a specific marker of sepsis in children and adults (Hatheril et al, 1999;Guven et al, 2002;Casado-Flores et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Markers for Early Sepsis Diagnosis in Children With Systemic Inflammatory Response Syndrome

Pavāre¹,

Grope²,

Kalniņš³

et al. 2009

Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences.

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“…Several studies have shown that PCT can be used in early and differential diagnosis of bacterial sepsis, and a sensitivity of 60%-100% and specificity of 79%-100% have been reported. Güven et al (19) reported that PCT, found to be more specific than C-reactive protein in the diagnosis of bacterial sepsis, can be used in the early diagnosis of bacterial infections in emergency departments. Steinwald et al (20) reported that PCT levels can be used as a marker for the degree of sepsis and mortality.…”

Section: Discussionmentioning

confidence: 99%