Plasma concentrations of copeptin, C-reactive protein and procalcitonin are positively correlated with APACHE II scores in patients with sepsis

Jiang, Li; Feng, Bing; Gao, Dongna; Yu, Zhuang

doi:10.1177/0300060514561136

Cited by 30 publications

(28 citation statements)

References 30 publications

(36 reference statements)

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“…[22–25] The role of CRP and PCT as potential biomarkers for infection has been unclear since earlier studies showed inconsistent results. [20,21,26,27] In our study, we found no association between CRP and PCT and sepsis-related mortality in pediatric patients. This lack of association could have been because all study participants suffered from severe infections.…”

Section: Discussioncontrasting

confidence: 62%

“…Therefore, the CRP was also included in the multivariate logistic regression. [20,21] The Hosmer–Lemeshow test was used to assess the goodness-of-fit of the logistic regression models. After the logistic regression equation was established, the logit probabilities of patients from both groups were calculated to verify internal and external validity.…”

Section: Methodsmentioning

confidence: 99%

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Development and validation of a mortality risk model for pediatric sepsis

Chen

et al. 2017

Medicine

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Pediatric sepsis is a burdensome public health problem. Assessing the mortality risk of pediatric sepsis patients, offering effective treatment guidance, and improving prognosis to reduce mortality rates, are crucial.We extracted data derived from electronic medical records of pediatric sepsis patients that were collected during the first 24 hours after admission to the pediatric intensive care unit (PICU) of the Hunan Children's hospital from January 2012 to June 2014. A total of 788 children were randomly divided into a training (592, 75%) and validation group (196, 25%). The risk factors for mortality among these patients were identified by conducting multivariate logistic regression in the training group. Based on the established logistic regression equation, the logit probabilities for all patients (in both groups) were calculated to verify the model's internal and external validities.According to the training group, 6 variables (brain natriuretic peptide, albumin, total bilirubin, D-dimer, lactate levels, and mechanical ventilation in 24 hours) were included in the final logistic regression model. The areas under the curves of the model were 0.854 (0.826, 0.881) and 0.844 (0.816, 0.873) in the training and validation groups, respectively.The Mortality Risk Model for Pediatric Sepsis we established in this study showed acceptable accuracy to predict the mortality risk in pediatric sepsis patients.

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Section: Discussioncontrasting

confidence: 62%

Section: Methodsmentioning

confidence: 99%

Development and validation of a mortality risk model for pediatric sepsis

Chen

et al. 2017

Medicine

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“…[18] In a small study evaluating 41 septic patients a strong correlation between copeptin and the disease severity score APACHE II was demonstrated. [19] In our cohort, only weak correlations between copeptin and APACHE II scores, as well as other established scores including the SAPS II and the SOFA score were demonstrated. Considering acute heart failure, several studies demonstrated elevated levels of copeptin being predictive of mortality, such as a substudy of the BACH study, including 557 patients with AHF.…”

Section: Discussionmentioning

confidence: 56%

Copeptin Predicts Mortality in Critically Ill Patients

et al. 2017

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BackgroundCritically ill patients admitted to a medical intensive care unit exhibit a high mortality rate irrespective of the cause of admission. Besides its role in fluid and electrolyte balance, vasopressin has been described as a stress hormone. Copeptin, the C-terminal portion of provasopressin mirrors vasopressin levels and has been described as a reliable biomarker for the individual’s stress level and was associated with outcome in various disease entities. The aim of this study was to analyze whether circulating levels of copeptin at ICU admission are associated with 30-day mortality.MethodsIn this single-center prospective observational study including 225 consecutive patients admitted to a tertiary medical ICU at a university hospital, blood was taken at ICU admission and copeptin levels were measured using a commercially available automated sandwich immunofluorescent assay.ResultsMedian acute physiology and chronic health evaluation II score was 20 and 30-day mortality was 25%. Median copeptin admission levels were significantly higher in non-survivors as compared with survivors (77.6 IQR 30.7–179.3 pmol/L versus 45.6 IQR 19.6–109.6 pmol/L; p = 0.025). Patients with serum levels of copeptin in the third tertile at admission had a 2.4-fold (95% CI 1.2–4.6; p = 0.01) increased mortality risk as compared to patients in the first tertile. When analyzing patients according to cause of admission, copeptin was only predictive of 30-day mortality in patients admitted due to medical causes as opposed to those admitted after cardiac surgery, as medical patients with levels of copeptin in the highest tertile had a 3.3-fold (95% CI 1.66.8, p = 0.002) risk of dying independent from APACHE II score, primary diagnosis, vasopressor use and need for mechanical ventilation.ConclusionCirculating levels of copeptin at ICU admission independently predict 30-day mortality in patients admitted to a medical ICU.

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“…It is present in low levels in the blood of healthy subjects. Recently, CRP and PCT have been investigated for potential to serve as important tools for the early diagnosis of bacterial infection in clinical applications (11,12).…”

Section: Introductionmentioning

confidence: 99%

Diagnostic values of red cell distribution width, platelet distribution width and neutrophil-lymphocyte count ratio for sepsis

Zhang

Chen

Lan

et al. 2016

Experimental and Therapeutic Medicine

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Abstract. The aim of this study was to evaluate the diagnostic efficiency of red blood cell distribution width (RDW), platelet distribution width (PDW), the neutrophil-lymphocyte count ratio (NLCR), procalcitonin (PCT) and C-reactive protein (CRP) for the prediction of sepsis. A total of 120 consecutive patients who underwent blood culture testing were included. The PCT and CRP levels, and RDW, PDW and NLCR percentages were determined and compared between patients with positive blood cultures and those without. The PCT, CRP, RDW, PDW and NLCR values were significantly higher in patients with positive blood culture compared with those without. PCT and NLCR each had a high diagnostic performance for the prediction of sepsis, with an area under the curve (AUC) for sepsis of 0.829 and 0.718, respectively. A combination of RDW, PDW and NLCR also exhibited a good diagnostic performance for sepsis (AUC, 0.704). NLCR is easily obtained by automated hematological analysis. Moreover, NLCR was found to have a high diagnostic efficiency for the prediction of sepsis, with greater sensitivity and accuracy than CRP. In conclusion, PCT exhibited the optimal diagnostic performance among the tested markers. The combination of the three parameters of RDW, PDW and NLCR, demonstrated a high diagnostic performance similar to that of PCT.

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Plasma concentrations of copeptin, C-reactive protein and procalcitonin are positively correlated with APACHE II scores in patients with sepsis

Cited by 30 publications

References 30 publications

Development and validation of a mortality risk model for pediatric sepsis

Development and validation of a mortality risk model for pediatric sepsis

Copeptin Predicts Mortality in Critically Ill Patients

Diagnostic values of red cell distribution width, platelet distribution width and neutrophil-lymphocyte count ratio for sepsis

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