IntroductionEven though sepsis is one of the common causes of children morbidity and mortality, specific inflammatory markers for identifying sepsis are less studied in children. The main aim of this study was to compare the levels of high-mobility group box-1 protein (HMGB1), Lipopolysaccharide-binding protein (LBP), Interleukin-6 (IL-6) and C-reactive protein (CRP) between infected children without systemic inflammatory response syndrome (SIRS) and children with severe and less severe sepsis. The second aim was to examine HMGB1, LBP, IL6 and CRP as markers for of bacteraemia.MethodsTotally, 140 children with suspected or proven infections admitted to the Children's Clinical University Hospital of Latvia during 2008 and 2009 were included. Clinical and demographical information as well as infection focus were assessed in all patients. HMGB1, LBP, IL-6 and CRP blood samples were determined. Children with suspected or diagnosed infections were categorized into three groups of severity of infection: (i) infected without SIRS (n = 36), (ii) sepsis (n = 91) and, (iii) severe sepsis (n = 13). They were furthermore classified according bacteraemia into (i) bacteremia (n = 30) and (ii) no bacteraemia (n = 74).ResultsThere was no statistically significant difference in HMGB1 levels between children with different levels of sepsis or with and without bacteraemia. The levels of LBP, IL-6 and CRP were statistically significantly higher among patients with sepsis compared to those infected but without SIRS (p < 0.001). Furthermore, LBP, IL-6 and CRP were significantly higher in children with severe sepsis compared to those ones with less severe sepsis (p < 0.001). Median values of LBP, IL6 and CRP were significantly higher in children with bacteraemia compared to those without bacteraemia. The area under the receiver operating curve (ROC) for detecting bacteraemia was 0.87 for both IL6 and CRP and 0.82 for LBP, respectively.ConclusionElevated levels of LBP, IL-6 and CRP were associated with a more severe level of infection in children. Whereas LBP, IL-6 and CRP seem to be good markers to detect patients with bacteraemia, HMGB1 seem to be of minor importance. LBP, IL-6 and CRP levels may serve as good biomarkers for identifying children with severe sepsis and bacteraemia and, thus, may be routinely used in clinical practice.

We present our study of the influence of the head 30 degrees flexion position on the changes in the muscle strength of the upper extremities. This position is typical for a person working in front of a computer.The study involved 100 healthy volunteers and was performed at the Department of Morphology in Riga Stradiņš University, Riga, Latvia. For measurements we have used the MicroFET2 Hand Held Digital Muscle Tester to determine the strength of the muscles of the hand and the arm (M. deltoideus, M. biceps brachii, M. triceps brachii, M. abductor pollicis longus). The results of measurements were then used to analyze the difference in the strength of the muscles innervated by the spinal cord cervical region (C5-C8 nerves) for the same person sitting in the vertical position and sitting with the head flexed at 30°.The results of our study support the hypothesis that the changes in the strength of the measured muscles are related to the mechanical distension of the spinal cord, which leads to changes in spinal cord's blood supply. The kyphosis position of the cervical spine during head flexion at 30°extent shows Papers on Anthropology XXVI/1, 2017, pp. 115-125 116 | J. Vetra, V. Sklarevich, G. Anoufriev et al. that in the spinal cord segments C5, C6 and C7 are form mechanical distension, but the changes in segment C8 were not detectable.Using our statistical study, we can conclude that there is strong relationship in the strength change in most of the observed muscles between the vertical position and the flexion of head at 30 degrees.

Introduction. Weight and height are important measurements for many medical procedures. They are difficult to measure in bedridden patients. They can be estimated through equations based on anthropometric measurements generated in other countries, however their adequacy in different ethnical groups has been poorly studied. Objective. To confirm the adequacy of formulae suggested in literature and to develop weight and height predicting equations for Latvian hospitalized seniors which use a tapeline as only tool and include no more than one measurement require turning bedridden patient. Methods. Anthropometric measurements were taken from hospitalized seniors (≥65 years) admitted to the Gerontology Centre, Riga East University Hospital. Actual body height and weight were compared with their estimates calculated from Chumlea, Rabito, Bernal, Lorenz, Crandell equations. Multiple linear regression analysis was used to create weight and height predictive models. The estimated and actual values were compared through a paired sample t-test. Results. 223 hospitalized seniors, 169 women and 54 men, were assessed. There was no significant difference between actual and estimated mean weight by Rabito in females. The Chumlea formula estimated height in both genders. The Chumlea, Bernal underestimated, but Lorenz and Crandell

We present our study of influence full cervical flexion position on the changes in muscle strength of the upper extremities. This position is typical for a person working on mobile phone or iPad. The purpose of the study was determination of the connection between change of the head flexed position and changes in upper extremity muscles strength. The present study involved 80 healthy volunteers and was performed at the Department of Morphology in Riga Stradins University, Riga, Latvia. For measurements we have used the MicroFET2 Hand Held Digital Muscle Tester to determine the strength of the muscles of the hand and arm (M. abductor pollicis longus, M. biceps brachii, M. triceps brachii, M. deltoideus). The results of measurements were then used to analyze the difference in the strength of the muscles innervated by the spinal cord cervical region (C5–C8 nerves) for the same person sitting in the vertical position and sitting with the head flexed maximally. The results of our study support the hypothesis that the changes in the strength of measured muscles are related to the mechanical distension of the spinal cord, which leads to changes in spinal cord's blood supply. The kyphotic position of the cervical spine during head flexion shows that in the spinal cord segments C5 and C7 are formed mechanical distension. Using our statistical study, we can conclude that there is strong relationship in the strength change in some of the observed muscles between vertical position and full flexion of head

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