Diagnostic Value of Procalcitonin Levels in Acute Mesenteric Ischemia

Karaca, Yunus; Gunduz, Abdülkadir; Turkmen, Süha; Menteşe, Ahmet; Türedi, Süleyman; Eryiğit, Umut; Karahan, Süleyman Caner

doi:10.5152/balkanmedj.2015.15661

Cited by 12 publications

(11 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Different findings were published in an ensuing study. Karaca et al induced experimental mesenteric ischemia in rats, and reported that PCT values display a late increase after mesenteric ischemia (i.e., after 6 hours), and can hence be only proposed as a late biomarker (48). Cosse et al also investigated the role of PCT for discriminating patients with and without intestinal ischemia.…”

Section: Inflammatory And/or Infection Biomarkersmentioning

confidence: 99%

Biochemical markers of acute intestinal ischemia: possibilities and limitations

2018

View full text Add to dashboard Cite

Acute intestinal ischemia is a relative rare abdominal emergency, associated with considerably high morbidity and mortality rates. Although the conventional diagnostic approach to acute intestinal ischemia entails a preliminary evaluation of signs and symptoms, followed by radiological and laboratory investigations, a definitive diagnosis is can usually be made after laparotomy, which still remains the gold standard diagnostic (and therapeutic) procedure. Several potential laboratory biomarkers have been investigated over the past decades, but none of these seems to reach a suitable diagnostic accuracy for an early and reliable diagnosis of intestinal ischemia. The aim of this narrative review is to provide an overview on traditional laboratory tests for diagnosing acute intestinal ischemia (i.e., complete blood count, D-dimer, blood gas analysis, total lactic acid, C-reactive protein and procalcitonin), and summarize current evidence regarding some emerging and potentially useful biomarkers such as D-lactate, intestinal fatty acid-binding protein (I-FABP), ischemia modified albumin (IMA), α-glutathione S-transferase (α-GST), interleukin-6 (IL-6), citrulline and smooth muscle protein of 22 kDa (SM22). Among the various tests, D-lactate, IMA and I-FABP are perhaps the most promising, since they are characterized by optimal sensitivity and relatively good specificity, early kinetics, and can be measured with assays suited for a rapid diagnosis.

show abstract

Section: Inflammatory And/or Infection Biomarkersmentioning

confidence: 99%

Biochemical markers of acute intestinal ischemia: possibilities and limitations

2018

View full text Add to dashboard Cite

show abstract

“…Clinically, AMI results from a coronary artery occlusion leading to myocardial ischemic necrosis. This condition induces a sterile inflammatory response, in which PCT is an important indicator of the intensity ( 18 ). The serum PCT level and vascular endothelial growth factor-B (VEGF-B) expression level in elderly patients with AMI were reported to have certain relevance with the patients' prognosis.…”

Section: Discussionmentioning

confidence: 99%

Clinical study of serum procalcitonin level in patients with myocardial infarction complicated by pulmonary infection

Sun

Wang

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

This study determined the serum procalcitonin (PCT) levels in patients with myocardial infarction complicated by pulmonary infection and explore its clinical significance and diagnostic value. A total of 473 patients who were admitted to the Third Affiliated Hospital of Qiqihar Medical University from January 2016 to June 2017 were enrolled as research subjects. Patients were divided into four groups based on their symptom status in myocardial infarction and pulmonary infection. There were 109 patients in normal control group who did not experience symptoms of either myocardial infarction or pulmonary infection. Blood samples were collected from each patient, and PCT levels were measured. The data were analyzed. The serum PCT levels prior to treatment were compared with each other. The PCT levels in the myocardial infarction and the pulmonary infection group were all higher than that in the normal control group (0.040±0.015) (p<0.05). On the contrary, the serum PCT level in the myocardial infarction complicated by pulmonary infection group was higher than that in the normal control group (p<0.001). The serum PCT level after treatment was compared with that before treatment within the same group. The serum PCT levels in the three disease groups were comparable after treatment. The differences in PCT levels before and after treatment were all statistically significant within all three groups (p<0.05). A patient's serum PCT level was correlated with myocardial infarction complicated by pulmonary infection, which suggested it can be used as an important diagnostic marker for this complication. This finding has important clinical value for predicting and evaluating the complicated condition of myocardial infarction and pulmonary infection by providing a more accurate, sensitive, and specific method for early diagnosis of the disease.

show abstract

“…[17] Karaağaç et al showed in an experimental study that IL-1ß, IL-6, and TNF-α levels rose in the 2 nd and 4 th hour after ischemic period. [18] In an experimental study of mesenteric artery ischemia conducted by Gunduz et al, ischemia-modified albumin was found to be significantly increased at the 2 nd and 4 th hour after ischemic period, though future research is warranted. [19] In an experimental study conducted by Uncu et al, ALT, AST, ALP, LDH, creatine kinase, and phosphorus levels rose in the first hour after the ischemic period, but none of those parameters were sufficiently specific for diagnosis of AMI.…”

Section: Discussionmentioning

confidence: 99%