Role Of Alkaline Phosphatase Intestine-Isomerase In Acute Mesenteric Ischemia Diagnosis

Lapsekili, Emin; Menteş, Öner; Balkan, Müjdat; Günal, Armağan; Yaman, Halıl; Kozak, Orhan; Peker, Yusuf

doi:10.5505/tjtes.2015.49475

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…However, Lapsekili et al . (20) reported an insignificant contribution of IAP in the diagnosis of acute mesenteric ischaemia. Using systemic IAP appears to be effective in alleviating the systemic inflammatory response associated with enterocolitis and may be accepted as a useful adjunctive treatment for necrotising enterocolitis (24).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of intestinal damage biomarkers in calves with atresia coli

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İder

et al. 2018

Journal of Veterinary Research

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IntroductionIntestinal obstruction such as atresia coli causes pathophysiological changes in gastrointestinal tissue due to the rise of intra-abdominal pressure. The aim of this study is to determine the intestinal damage with intestinal biomarkers in calves with atresia coli.Material and MethodsThe study was conducted on 40 Holstein calves diagnosed with atresia coli with mild to moderate abdominal distention and 10 healthy Holstein calves which served as the control. Blood samples were collected from all calves, and then serum concentrations of intestinal biomarkers were estimated, namely intestinal fatty acid binding protein (IFABP), liver fatty acid binding protein (LFABP), trefoil factor 3 (TFF3), and intestinal alkaline phosphatase (IAP), using commercially available specific bovine ELISA kits. An automatic blood gas analyser was employed for determining the lactate concentration.ResultsThe concentrations of serum LFABP (P < 0.01), IFABP, TFF3, IAP, and blood lactate (P < 0.001) were significantly higher in calves with atresia coli than in healthy calves.ConclusionThe calves affected with atresia coli exhibited severe intestinal damage, and IFABP, LFABP, and TFF3 have significant diagnostic importance and play a useful role in determining the intestinal damage due to intestinal obstruction. High levels of IAP and lactate may serve as a signal for the development of intestinal injury.

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Section: Discussionmentioning

confidence: 99%

Evaluation of intestinal damage biomarkers in calves with atresia coli

Yıldız

İder

et al. 2018

Journal of Veterinary Research

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Outcomes of oxytocin treatment on intestinal ischemia-reperfusion injury in rats

Gültekin,

Sayıner,

Çetinel

et al. 2024

Ankara Üniversitesi Veteriner Fakültesi Dergisi

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Ischemia-reperfusion injury is a clinical condition that poses a life-threatening risk due to certain diseases or operations such as trauma, shock, and gastric dilatation volvulus. The study's objective was to investigate the impact of oxytocin on intestinal damage in rats caused by ischemia-reperfusion injury induced experimentally. Three groups of Wistar albino rats were formed: Control (CTR, n=6), intestinal ischemia-reperfusion (I-IR, n=6), and intestinal ischemia-reperfusion+ Oxytocin (I-IR+Oxt, n=6). Oxytocin (1 mg/kg) was given intraperitoneally to the I-IR+Oxt group 30 min prior to the anesthesia. In the I-IR and I-IR+Oxt groups, ischemia reperfusion was performed with 1 h ligation of the superior mesenteric artery and one hour reperfusion by opening the ligatures. After the end of the reperfusion period, euthanasia was performed and blood and intestinal tissue samples were taken. From the blood samples, ALT, ALP, AST, LDH, BUN, creatinine, IL-1β, TNF-α, concentrations and from the tissue sample, IL-1β, TNF-α and MDA activities were evaluated. While serum and tissue IL-1β, TNF-α concentrations were greater in both I-IR and I-IR+Oxt groups compared to the CTR group, these levels were determined to be lower in the I-IR+Oxt group compared to the I-IR group. Histopathological analysis showed that epithelial regeneration of both epithelium and glands structure and decreased inflammatory cell infiltration were found in the I-IR+Oxt group compared to the I-I/R group. In conclusion, oxytocin inhibited the release of IL-1β and TNF-α and the harmful effect of IR on intestinal cells.

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Role Of Alkaline Phosphatase Intestine-Isomerase In Acute Mesenteric Ischemia Diagnosis

Abstract: BACKGROUND:The aim of the present study was to investigate the diagnostic value of alkaline phosphatase (ALP) intestineisomerase, plasma lactate dehydrogenase (LDH), and D-dimer levels in acute mesenteric ischemia.

Cited by 2 publications

References 22 publications

Evaluation of intestinal damage biomarkers in calves with atresia coli

Evaluation of intestinal damage biomarkers in calves with atresia coli

Outcomes of oxytocin treatment on intestinal ischemia-reperfusion injury in rats

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