Diagnosis and management of leukaemia in dogs and cats

Dobson, Jerome E.; Villiers, Elizabeth; Morris, J. H.

doi:10.1136/inpract.28.1.22

Cited by 15 publications

(36 citation statements)

References 4 publications

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“…A leucemia linfocítica foi diagnosticada durante uma consulta de rotina, sendo observada leucocitose devido à linfocitose acentuada, coerente com a literatura (SHIMO-MURA, 2006;DOBSON, 2006;FRANCO, 2008). Os sinais clínicos, considerados inespecíficos, como anorexia, perda de peso, vômito, diarreia intermitente, poliúria, polidipsia e pirexia, relatados por Shimomura (2006) e Dobson (2006), não foram observados no presente caso.…”

Section: Discussionunclassified

“…A leucemia linfocítica é uma afecção maligna e progressiva, marcada por uma proliferação desordenada de linfócitos maduros morfologicamente normais na medula óssea ou no sangue periférico (SHIMOMURA, 2006;DOBSON, 2006;FRANCO, 2008). De acordo com a linhagem leucocitária afetada, as leucemias são classificadas como linfoide e mieloide (HARVEY, 2001).…”

Section: Introductionunclassified

“…Segundo Lorenzi (2006), a leucemia linfocítica em pacientes humanos é considerada benigna quando comparadas com outro tipo de leucemias. É relatada em cães idosos e sem predileção por raça (SHI-MOMURA, 2006;DOBSON, 2006). A idade média dos cães acometidos é de 9,4 anos, e a relação macho e fêmea é de 2:1 (TILLEY, 2003).…”

Section: Introductionunclassified

“…Os sinais clínicos são inespecíficos, mas pode-se observar letargia, anorexia, perda de peso, vômito, diarreia intermitente, poliúria, polidipsia e pirexia (SHIMOMURA, 2006;DOBSON, 2006). O histórico de cronicidade dos sinais clínicos precede o diagnóstico da leucemia linfocítica em aproximadamente metade dos cães acometidos (SHIMO-MURA, 2006).…”

Section: Introductionunclassified

“…O histórico de cronicidade dos sinais clínicos precede o diagnóstico da leucemia linfocítica em aproximadamente metade dos cães acometidos (SHIMO-MURA, 2006). Por outro lado, a afecção pode ser identificada como achado incidental de linfocitose no hemograma de rotina (SHIMOMURA, 2006;DOBSON, 2006;FRANCO, 2008).…”

Section: Introductionunclassified

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Leucemia Linfocítica B Em Cão Jovem: Relato De Caso

Santos

Brombini

Tannus

et al. 2016

ArqVet

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RESUMO:O presente relato teve como objetivo descrever um caso de leucemia linfocítica B em um cão da raça maltês, fêmea, com três anos de idade, demonstrando a metodologia de diagnóstico e a variação da patologia clínica após o tratamento exclusivamente por esplenectomia. A linfocitose acentuada observada no hemograma e presença proliferativa de linfócitos na medula óssea determinou a suspeita da leucemia linfocítica. A leucemia linfocítica B foi diagnosticada por meio da citologia aspirativa da medula óssea, imunocitoquímica e citometria de fluxo. O tratamento foi exclusivamente por esplenectomia e dois anos após a cirurgia o animal não apresentou recidiva da afecção. PALAVRAS-CHAVE: Doenças linfoproliferativas. Linfócitos. Imunocitoquimica. Medula óssea. Pequenos animais. B -LYMPHOCYTIC LEUKEMIA IN YOUNG DOG: CASE REPORTABSTRACT: This report aimed to describe a case of B lymphocytic leukemia in maltese female dog, three years old, demonstrating the methodology of diagnostic and variation of clinical pathology after treatment exclusively by splenectomy. The accentuate lymphocytes observed in blood counts and presence of proliferative lymphocytes in the bone marrow were determined to diagnostic of lymphocytic leukemia. The B lymphocytic leukemia was diagnosed by bone marrow aspiration cytology, immunocytochemistry and flow cytometry. The treatment was exclusively by splenectomy and two years after the surgery the animal showed no recurrence of the disease. KEY WORDS: Linfoproliferative disease. Lymphocytes. Immunocytochemistry. Bone marrow. Small animals. LEUCEMIA LINFOCÍTICA B EN PERRO JOVEN: RELATO DE CASORESUMEN: El objetivo de ese relato ha sido describir un caso de leucemia linfocítica B en un perro, raza maltés, hembra, de tres años, demostrando la metodología de diagnóstico y la variación de la patología clínica, después del tratamiento exclusivamente por esplenectomía. La linfocitosis aguda, observada en el hemograma, y la presencia de proliferación de linfocitos en la médula ósea, determinó la sospecha de leucemia linfocítica. La leucemia linfocítica B fue diagnosticada mediante la citología por aspiración de médula ósea, inmunocitoquímica y citometría de flujo. El tratamiento fue exclusivamente por esplenectomía y dos años después de la cirugía el animal no mostró recurrencia de la enfermedad.

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Section: Discussionunclassified

Section: Introductionunclassified

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Leucemia Linfocítica B Em Cão Jovem: Relato De Caso

Santos

Brombini

Tannus

et al. 2016

ArqVet

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RAS, FLT3, and C-KIT mutations in immunophenotyped canine leukemias

Usher

Radford

Villiers

et al. 2009

Experimental Hematology

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Clinical pathological and epidemiological assessment of morphologically and immunologically confirmed canine leukaemia

Adam

Villiers²,

Watson

et al. 2009

Vet Comparative Oncology

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Traditionally, classification of leukaemia in dogs has relied on morphological examination and cytochemical staining patterns, but aberrant cellular morphology and stain uptake often curtails accurate categorization, and historical data based on this classification may be unreliable. Immunophenotyping is now the gold standard for classification of leukaemias. The purpose of this prospective study was to assess the clinical pathological and epidemiological features of a population of dogs with morphologically and immunologically confirmed leukaemia and to compare them within categories: acute and chronic lymphoid leukaemia (ALL and CLL), and acute and chronic myeloid leukaemia (AML and CML). There were 64 cases of morphologically and immunologically confirmed leukaemia: 25 cases of ALL, 17 cases of CLL and 22 cases of AML. Prevalence of B and T immunophenotypes in ALL and CLL was not statistically different. Dogs with AML were significantly younger than those with ALL at presentation (P = 0.04). Golden Retriever dogs in the study population were overrepresented in comparison with a control population of dogs (6/25 ALL cases, 8/64 leukaemia cases). No sex was overrepresented. Dogs with ALL had significantly more severe neutropenia (P = 0.001) and thrombocytopenia (P = 0.002) than those with CLL and had significantly more cytopenias. The severity and numbers of cytopenias seen in ALL and AML were not significantly different. Twenty-one of the leukaemia cases showed one cytopenia, fourteen had two cytopenias and twenty-one cases had pancytopenia. Anaemia was the most common cytopenia seen in isolation (17/21). No dogs had neutropenia without anaemia and/or thrombocytopenia. Total white blood cell counts were not different between the groups. The atypical cell counts within the peripheral blood were significantly higher in ALL than AML; both in isolation and as a percentage of the total white blood cell count (P = 0.03). This study strengthens the hypothesis that acute leukaemias give rise to more profound cytopenias, affecting more cell lines, than chronic leukaemias.

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Diagnosis and management of leukaemia in dogs and cats

Cited by 15 publications

References 4 publications

Leucemia Linfocítica B Em Cão Jovem: Relato De Caso

Leucemia Linfocítica B Em Cão Jovem: Relato De Caso

RAS, FLT3, and C-KIT mutations in immunophenotyped canine leukemias

Clinical pathological and epidemiological assessment of morphologically and immunologically confirmed canine leukaemia

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