Diabetes: Symptoms, Cause and Potential Natural Therapeutic Methods

Awasthi, Anjali; Parween, Nikhat; Singh, Vijay Kumar; Anwar, Arif; Prasad, Birendra; Kumar, Jitendra

doi:10.13189/adm.2016.040102

Cited by 12 publications

(6 citation statements)

References 118 publications

(150 reference statements)

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“…Pandit and Pandey [1]; Awasthi et al [2] proposed that diabetes mellitus is a multi-factorial metabolic disorder and forthcoming epidemic all over the globe that caused due to ineffective secretion of insulin. Prajapat and Bhattacharya [3]; Zhaolan et al [4] proposed that diabetic patient numbers will possibly rise up to 300 million by 2025 in India.…”

Section: Introductionmentioning

confidence: 99%

Combined Effect of Vitamin C and E Dose on Type 2 Diabetes Patients

Prajapat¹,

Bhattacharya²,

Jakhalia³

2017

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Diabetes is a metabolic disorder that causes vascular complications. As vitamin C and E is known for its beneficial effects on blood sugar, serum lipids and glycated haemoglobin (HbA1c). In the present study, we assess the combined effect of vitamin C and E on blood sugar (FBS), serum creatinine (SC), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), and glycated haemoglobin (HbAIc) in type 2 diabetes mellitus patients. A total of 50 patients with type 2 diabetes referred to Rama Hospital (NCR), India, were included in the study. They received 500 mg daily twice of both vitamin C and E for 4 months. Fasting blood sugar (FBS), serum creatinine (SC), total cholesterol (TC), low and high density lipoprotein (LDL, HDL), and HbAIc were measured before and after vitamin C and E consumption and the results were analyzed. A significant decrease in FBS, TC level and non-significant decrease in SC, LDL, and HbA1c level was seen in the patients supplemented with 500 mg of both vitamin C and E twice in a day for 4 months. Results indicate that daily consumption of 500 mg of vitamin C and E for 4 months may be beneficial for decreasing the FBS, TC, SC, LDL, and HbA1c and slight raise in HDL and calcium level in patients with type II diabetes and thus reducing the risk of complications.

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Section: Introductionmentioning

confidence: 99%

Combined Effect of Vitamin C and E Dose on Type 2 Diabetes Patients

Prajapat¹,

Bhattacharya²,

Jakhalia³

2017

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“…Previous studies by Chikhi et al (2014) [46] confirmed high anti-diabetic activities in Atriplex halimus. During the last few decades, medicinal plants like Allium sativum, Eugenia jambolana, Momordica charantia, Ocimum sanctum, Phyllanthus amarus, Pterocarpus marsupium, Tinospora cordifolia, Trigonella foenum graecum, and Withania somnifera with proven antidiabetic properties were used for developing natural, safe, and cost-effective herbal anti-diabetic drugs [47], and were supplemented with a plethora of bioactive compounds such as alkaloids, glycosides, terpenes, flavonoids, etc., [48]. However, Ecuadorian herbs like Schinus molle, Opuntia soehrensii, Lepidium meyenii, Cyclanthera pedate, Smilax officinalis, Uncaria tomentosa, etc., used in traditional medicine are reported to possess anti-diabetic, anti-oxidant, anti-inflammatory, and anti-hypoglycemic activities [27].…”

Section: Diabetic Burden and Its Impact On The Health And Economy Of ...mentioning

confidence: 99%

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Bhattacharya,

Gupta,

Flekalová

et al. 2024

Preprint

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Diabetes mellitus (DM) is a metabolic disorder characterized by the deficiency of insulin production and is one of the concerning health problems worldwide, especially in developing countries. Considering the systemic toxicity associated with current antidiabetic medications and their limited efficacy, there is an urgent need to discover new plant-based natural antidiabetics. Since time immemorial, medicinal plants have played an important role in the management of health disorders. In recent years, herbal medicine has experienced exponential growth in popularity worldwide, owing to its natural origin and fewer side effects, appealing to both developing and developed nations. Ecuador has a rich cultural history in ethnobotany that plays a crucial role in their people's lives. Several Ecuadorian medicinal plants have hypoglycemic or an-ti-hyperglycemic properties that are rich with bioactive phytochemicals. These medicinal plants were extensively used in traditional medicine preparation in Ecuador for many decades to treat diabetes because of their cost-effectiveness, available traditional knowledge, and low toxicity. Many Ecuadorian medicinal plants are reported to have antidiabetic properties that reduce blood sugar levels, and oxidative stress, regulate intestinal function, improve insulin resistance, inhibit α-amylase and α-glucosidase, lower gluconeogenic enzymes, stimulate glucose uptake mechanisms, and play an important role in glucose and lipid metabolism, yet there is a substantial lack of integrated approach between the existing ethnomedicinal practice and pharmacological research. Therefore, this review aims to discuss and explore the traditional medicinal plants used in Ecuador for treating DM and their bioactive phytochemicals, which are mainly responsible for their anti-diabetic properties.

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“…Type 1 diabetes is an autoimmune disease that causes pancreas β cell damage resulting in insulin deficiency, whereas type 2 diabetes develops due to inefficient use of insulin or insufficient insulin production. 1 Prevalence of diabetes in the world in the adult age range 20 -79 year by 6.4% affecting 285 million (2010). It will increase to 7.7% and 439 million people by 2030.…”

Section: Introductionmentioning

confidence: 99%

Aloe Vera Peel Extract Administration Increased Antioxidant Enzyme Levels of Serum and Seminal Plasma in Type 2 Diabetic Rats

Christijanti¹,

Juniarto²,

Suromo³

2019

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Background: Diabetes mellitus (DM) is considered as a complex metabolic disorder characterized by hyperglycemia. Aim: The present study aimed to evaluate the effect of Aloe vera peel extract on the antioxidant levels of serum and seminal plasma of type 2 diabetic rats. Materials and Methods: Male Wistar rat was injected by 65 mg/kg streptozotocin (STZ) combined with 230 mg/kg of Nicotinamide acid (NA) intraperitoneally. The rats were declared to have diabetic with fasting blood glucose level > 200 mg/dl 72 hours after induction. Diabetic rat samples were divided into four groups, control group (diabetes without treatment) and three groups were treated by Aloe vera peel extracts orally: 100 mg (P.1), 200 mg (P.2), and 400 mg/kg body weight (P.3), respectively. Antioxidant levels of serum and seminal plasma, including superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were examined after 28 days of treatment. Results: The levels of SOD, CAT, and GSH in the group receiving Aloe vera peel extract were statistically significant (p <0.05) higher than the control. There were also significant differences between the dose variations group. Conclusion: Aloe vera peel extract can significantly increase antioxidant levels in serum and seminal plasma of type 2 diabetic mice.

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Diabetes: Symptoms, Cause and Potential Natural Therapeutic Methods

Cited by 12 publications

References 118 publications

Combined Effect of Vitamin C and E Dose on Type 2 Diabetes Patients

Combined Effect of Vitamin C and E Dose on Type 2 Diabetes Patients

Exploring Folklore Ecuadorian Medicinal Plants and Their Bioactive Components Focusing on Antidiabetic Potential: An Overview

Aloe Vera Peel Extract Administration Increased Antioxidant Enzyme Levels of Serum and Seminal Plasma in Type 2 Diabetic Rats

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