Aloe Vera Peel Extract Administration Increased Antioxidant Enzyme Levels of Serum and Seminal Plasma in Type 2 Diabetic Rats

Abstract

Background: Diabetes mellitus (DM) is considered as a complex metabolic disorder characterized by hyperglycemia. Aim: The present study aimed to evaluate the effect of Aloe vera peel extract on the antioxidant levels of serum and seminal plasma of type 2 diabetic rats. Materials and Methods: Male Wistar rat was injected by 65 mg/kg streptozotocin (STZ) combined with 230 mg/kg of Nicotinamide acid (NA) intraperitoneally. The rats were declared to have diabetic with fasting blood glucose level > 200 mg/dl 72 hours after induction. Diabetic rat samples were divided into four groups, control group (diabetes without treatment) and three groups were treated by Aloe vera peel extracts orally: 100 mg (P.1), 200 mg (P.2), and 400 mg/kg body weight (P.3), respectively. Antioxidant levels of serum and seminal plasma, including superoxide dismutase (SOD), catalase (CAT) and glutathione (GSH) were examined after 28 days of treatment. Results: The levels of SOD, CAT, and GSH in the group receiving Aloe vera peel extract were statistically significant (p <0.05) higher than the control. There were also significant differences between the dose variations group. Conclusion: Aloe vera peel extract can significantly increase antioxidant levels in serum and seminal plasma of type 2 diabetic mice.

Aloe vera and Streptozotocin-Induced Diabetes Mellitus

“…Glutathione levels and antioxidant enzymatic activities (SOD and CAT) were also found to increase in diabetic rats treated with A. vera extract (Christijanti et al 2019a ). DNA fragmentation and the intracellular concentration of 8-oxo-2′-deoxyguanosine were also increased significantly in diabetic patients (Shin et al 2001 ; Rama Raju et al 2012 ).…”