Dextran based amphiphilic nano-hybrid hydrogel system incorporated with curcumin and cerium oxide nanoparticles for wound healing

Andrabi, Syed Muntazir; Majumder, S. B.; Gupta, Kailash C.; Kumar, Ashok

doi:10.1016/j.colsurfb.2020.111263

Cited by 93 publications

(61 citation statements)

References 64 publications

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“…The IR spectra of raw materials and drug-loaded fibers were obtained to explore the possible compatibility of components ( Figure 3 b). The characteristic peaks at 3510, 1602, 1506, and 1152 cm −1 of Cur demonstrate hydroxyl (-OH), carbonyl (-C=O), olefins (-C=C-), and ether (-C-O) groups, respectively [ 45 , 57 , 58 ]. The characteristic -C=O groups of PHBV and PVP were observed in 1720 and 1649 cm −1 , respectively [ 59 , 60 ].…”

Section: Resultsmentioning

confidence: 99%

Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug

et al. 2022

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In a drug delivery system, the physicochemical properties of the polymeric matrix have a positive impact on the bioavailability of poorly water-soluble drugs. In this work, monolithic F1 fibers and coaxial F2 fibers were successfully prepared using polyvinylpyrrolidone as the main polymer matrix for drug loading and the poorly water-soluble curcumin (Cur) as a model drug. The hydrophobic poly (3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) was designed as a blank layer to change the hydrophilicity of the fiber and restrain the drug dissolution rate. The curved linear morphology without beads of F1 fibers and the straight linear morphology with few spindles of F2 fibers were characterized using field-emission environmental scanning electron microscopy. The amorphous forms of the drug and its good compatibility with polymeric matrix were verified by X-ray diffraction and attenuated total reflectance Fourier transformed infrared spectroscopy. Surface wettability and drug dissolution data showed that the weaker hydrophilicity F2 fibers (31.42° ± 3.07°) had 24 h for Cur dissolution, which was much longer than the better hydrophilic F1 fibers (15.31° ± 2.79°) that dissolved the drug in 4 h.

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Section: Resultsmentioning

confidence: 99%

Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug

et al. 2022

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“…They attributed the selective cytotoxicity of the nanocomposite to the synergistic effect of ZnO NPs and curcumin. Andarabi et al [102] have also obtained better mechanical stability and stable elastic behavior by incorporating ceria and curcumin in gelatin-glucan-based hydrogel. The pure hydrogel demonstrated a ~252% swelling ratio, and nanoparticle incorporation had not reduced the swelling ratio significantly.…”

Section: Curcumin-metal Oxides Incorporated Hydrogelsmentioning

confidence: 99%

Curcumin Nanoformulations with Metal Oxide Nanomaterials for Biomedical Applications

et al. 2021

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In the past few decades, curcumin, a natural polyphenolic phytochemical, has been studied for treating a wide variety of diseases. It has shown promising results as a potential curative agent for a variety of diseases. However, its inherent limitations, such as poor aqueous solubility, poor absorbability, fast metabolic rate, and quick elimination from the body, have limited its application beyond preclinical studies. A huge number of studies have been made to address the issues of curcumin and to maximally utilize its potentials. Many review articles have tried to assess and summarize different nanocarriers, especially organic nanocarriers, for nanoformulations with curcumin. Nevertheless, few exclusive reviews on the progress in nanoformulation of curcumin with inorganic nanomaterials have been made. In this review, we present an exclusive summary of the progress in nanoformulation of curcumin with metal oxide nanoparticles. The beneficial feature of the metal oxide nanoparticles used in the curcumin nanoformulation, the different approaches followed in formulating curcumin with the metal oxides, and the corresponding results, protective effect of curcumin from different metal oxide caused toxicities, and concluding remarks are presented in the review.

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“…In order to prevent these complications, huge numbers of substances, techniques, and technologies have been developed and used in the clinical setting [ 33 , 34 , 35 ]. Among the various materials applied in treating soft-tissue wounds, nanoceria has shown great promises during both in vitro and in vivo experiments [ 36 , 37 , 38 ]. In Section 2 , the benefits of nanoceria for soft-tissue repair and regeneration will be introduced and discussed.…”

Section: Wound Healing: What We Know and Needmentioning

confidence: 99%

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

et al. 2020

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Several biocompatible materials have been applied for managing soft tissue lesions; cerium oxide nanoparticles (CNPs, or nanoceria) are among the most promising candidates due to their outstanding properties, including antioxidant, anti-inflammatory, antibacterial, and angiogenic activities. Much attention should be paid to the physical properties of nanoceria, since most of its biological characteristics are directly determined by some of these relevant parameters, including the particle size and shape. Nanoceria, either in bare or functionalized forms, showed the excellent capability of accelerating the healing process of both acute and chronic wounds. The skin, heart, nervous system, and ophthalmic tissues are the main targets of nanoceria-based therapies, and the other soft tissues may also be evaluated in upcoming experimental studies. For the repair and regeneration of soft tissue damage and defects, nanoceria-incorporated film, hydrogel, and nanofibrous scaffolds have been proven to be highly suitable replacements with satisfactory outcomes. Still, some concerns have remained regarding the long-term effects of nanoceria administration for human tissues and organs, such as its clearance from the vital organs. Moreover, looking at the future, it seems necessary to design and develop three-dimensional (3D) printed scaffolds containing nanoceria for possible use in the concepts of personalized medicine.

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Dextran based amphiphilic nano-hybrid hydrogel system incorporated with curcumin and cerium oxide nanoparticles for wound healing

Cited by 93 publications

References 64 publications

Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug

Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug

Curcumin Nanoformulations with Metal Oxide Nanomaterials for Biomedical Applications

Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering

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