Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug

Liu, Yubo; Chen, Xiaohong; Liu, Yuyang; Gao, Yuhang; Liu, Ping

doi:10.3390/polym14030469

Cited by 39 publications

(22 citation statements)

References 64 publications

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“…The last phase III occurs simultaneously with polymer degradation and is characterized by a slow release of BSA from the eroding matrix or through the pores [ 51 ]. The value of n < 0.45 (characteristic for Fickian diffusion), which was obtained from the Ritger-Peppas model, indicated that diffusion was the dominant release process [ 52 ]. The dependence of the obtained release profiles on the type of surfactant may result from the different morphology of the core part of the fibers.…”

Section: Discussionmentioning

confidence: 99%

Effect of Ionic and Non-Ionic Surfactant on Bovine Serum Albumin Encapsulation and Biological Properties of Emulsion-Electrospun Fibers

et al. 2022

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Emulsion electrospinning is a method of modifying a fibers’ surface and functional properties by encapsulation of the bioactive molecules. In our studies, bovine serum albumin (BSA) played the role of the modifier, and to protect the protein during the electrospinning process, the W/O (water-in-oil) emulsions were prepared, consisting of polymer and micelles formed from BSA and anionic (sodium dodecyl sulfate–S) or nonionic (Tween 80–T) surfactant. It was found that the micelle size distribution was strongly dependent on the nature and the amount of the surfactant, indicating that a higher concentration of the surfactant results in a higher tendency to form smaller micelles (4–9 µm for S and 8–13 µm for T). The appearance of anionic surfactant micelles reduced the diameter of the fiber (100–700 nm) and the wettability of the nonwoven surface (up to 77°) compared to un-modified PCL polymer fibers (100–900 nm and 130°). The use of a non-ionic surfactant resulted in better loading efficiency of micelles with albumin (about 90%), lower wettability of the nonwoven fabric (about 25°) and the formation of larger fibers (100–1100 nm). X-ray photoelectron spectroscopy (XPS) was used to detect the presence of the protein, and UV-Vis spectrophotometry was used to determine the loading efficiency and the nature of the release. The results showed that the location of the micelles influenced the release profiles of the protein, and the materials modified with micelles with the nonionic surfactant showed no burst release. The release kinetics was characteristic of the zero-order release model compared to anionic surfactants. The selected surfactant concentrations did not adversely affect the biological properties of fibrous substrates, such as high viability and low cytotoxicity of RAW macrophages 264.7.

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Section: Discussionmentioning

confidence: 99%

Effect of Ionic and Non-Ionic Surfactant on Bovine Serum Albumin Encapsulation and Biological Properties of Emulsion-Electrospun Fibers

et al. 2022

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“…In the traditional sense, the concentric spinneret is utilized to prepare the core–shell nanofibers [ 67 , 68 ]. However, in the coaxial system, when the shell fluid flow rate ( f s ) is adjusted to 0 mL/h, the process is degraded to a single-fluid blending process of the core fluid, and the final products are, correspondingly, homogeneous nanocomposites.…”

Section: Resultsmentioning

confidence: 99%

Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

Liu

Zhang

Song

et al. 2022

Gels

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The gels of cellulose and its derivatives have a broad and deep application in pharmaceutics; however, limited attention has been paid to the influences of other additives on the gelation processes and their functional performances. In this study, a new type of electrospun core–shell nanohybrid was fabricated using modified, coaxial electrospinning which contained composites of hydroxypropyl methyl cellulose (HPMC) and acetaminophen (AAP) in the core sections and composites of PVP and sucralose in the shell sections. A series of characterizations demonstrated that the core–shell hybrids had linear morphology with clear core–shell nanostructures, and AAP and sucralose distributed in the core and shell section in an amorphous state separately due to favorable secondary interactions such as hydrogen bonding. Compared with the electrospun HPMC–AAP nanocomposites from single-fluid electrospinning of the core fluid, the core–shell nanohybrids were able to promote the water absorbance and HMPC gelation formation processes, which, in turn, ensured a faster release of AAP for potential orodispersible drug delivery applications. The mechanisms of the drug released from these nanofibers were demonstrated to be a combination of erosion and diffusion mechanisms. The presented protocols pave a way to adjust the properties of electrospun, cellulose-based, fibrous gels for better functional applications.

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“…Although characteristic peaks of PEG did not appear in the spectrum of F2 and F3 fibres, a higher PEG content in F4 fibres showed clear characteristic peaks at 2876 cm –1 in the FTIR spectrum. Cur exhibited a carbonyl (C = O) at 1626 and 1602 cm –1 and olefins (-C = C-) at 1506 cm –1 [ 48 – 50 ]. F1–F4 fibres had the characteristic peaks of carbonyl and olefins of Cur, which proved that Cur had been successfully encapsulated.…”

Section: Resultsmentioning

confidence: 99%

Elaborate design of shell component for manipulating the sustained release behavior from core–shell nanofibres

et al. 2022

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Background The diversified combination of nanostructure and material has received considerable attention from researchers to exploit advanced functional materials. In drug delivery systems, the hydrophilicity and sustained–release drug properties are in opposition. Thus, difficulties remain in the simultaneous improve sustained–release drug properties and increase the hydrophilicity of materials. Methods In this work, we proposed a modified triaxial electrospinning strategy to fabricate functional core–shell fibres, which could elaborate design of shell component for manipulating the sustained-release drug. Cellulose acetate (CA) was designed as the main polymeric matrix, whereas polyethylene glycol (PEG) was added as a hydrophilic material in the middle layer. Cur, as a model drug, was stored in the inner layer. Results Scanning electron microscopy (SEM) results and transmission electron microscopy (TEM) demonstrated that the cylindrical F2–F4 fibres had a clear core–shell structure. The model drug Cur in fibres was verified in an amorphous form during the X-ray diffraction (XRD) patterns, and Fourier transformed infrared spectroscopy (FTIR) results indicated good compatibility with the CA matrix. The water contact angle test showed that functional F2–F4 fibres had a high hydrophilic property in 120 s and the control sample F1 needed over 0.5 h to obtain hydrophilic property. In the initial stage of moisture intrusion into fibres, the quickly dissolved PEG component guided the water molecules and rapidly eroded the internal structure of functional fibres. The good hydrophilicity of F2–F4 fibres brought relatively excellent swelling rate around 4600%. Blank outer layer of functional F2 fibres with 1% PEG created an exciting opportunity for providing a 96 h sustained-release drug profile, while F3 and F4 fibres with over 3% PEG provided a 12 h modified drug release profile to eliminate tailing–off effect. Conclusion Here, the functional F2–F4 fibres had been successfully produced by using the advanced modified triaxial electrospinning nanotechnology with different polymer matrices. The simple strategy in this work has remarkable potential to manipulate hydrophilicity and sustained release of drug carriers, meantime it can also enrich the preparation approaches of functional nanomaterials. Graphical Abstract

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Electrospun Coaxial Fibers to Optimize the Release of Poorly Water-Soluble Drug

Cited by 39 publications

References 64 publications

Effect of Ionic and Non-Ionic Surfactant on Bovine Serum Albumin Encapsulation and Biological Properties of Emulsion-Electrospun Fibers

Effect of Ionic and Non-Ionic Surfactant on Bovine Serum Albumin Encapsulation and Biological Properties of Emulsion-Electrospun Fibers

Electrospun Core (HPMC–Acetaminophen)–Shell (PVP–Sucralose) Nanohybrids for Rapid Drug Delivery

Elaborate design of shell component for manipulating the sustained release behavior from core–shell nanofibres

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