Curcumin Nanoformulations with Metal Oxide Nanomaterials for Biomedical Applications

Abstract

In the past few decades, curcumin, a natural polyphenolic phytochemical, has been studied for treating a wide variety of diseases. It has shown promising results as a potential curative agent for a variety of diseases. However, its inherent limitations, such as poor aqueous solubility, poor absorbability, fast metabolic rate, and quick elimination from the body, have limited its application beyond preclinical studies. A huge number of studies have been made to address the issues of curcumin and to maximally utilize its potentials. Many review articles have tried to assess and summarize different nanocarriers, especially organic nanocarriers, for nanoformulations with curcumin. Nevertheless, few exclusive reviews on the progress in nanoformulation of curcumin with inorganic nanomaterials have been made. In this review, we present an exclusive summary of the progress in nanoformulation of curcumin with metal oxide nanoparticles. The beneficial feature of the metal oxide nanoparticles used in the curcumin nanoformulation, the different approaches followed in formulating curcumin with the metal oxides, and the corresponding results, protective effect of curcumin from different metal oxide caused toxicities, and concluding remarks are presented in the review.

Curcumin as a novel reducing and stabilizing agent for the green synthesis of metallic nanoparticles

“…Copper oxide nanoparticles are a narrow bandgap ptype semiconductor. CuO NPs own different properties like good electrochemical activities, proper redox potential, and outstanding stability in solutions (52).…”

“…Some of these techniques include the use of curcumin with nanoparticles, the use of adjuvants such as piperine, formulating liposomal curcumin, etc (51). Consequently, curcumin in nanoparticle formation has been introduced (52).…”

Curcumin and Its Modified Formulations on Inflammatory Bowel Disease (IBD): The Story So Far and Future Outlook

“…Curcumin derived from Curcuma longa L. is involved in many important genetic and biochemical pathways and produces protective effects against several diseases. It is a harmless natural compound and also a potential therapeutic drug against various diseases [13][14][15][16]. Extensive research evidence supports the anti-inflammatory, antioxidant, antitumor, antimicrobial, and wound-healing effects of curcumin [17][18][19][20][21].…”

New Construction of Functionalized CuO/Al2O3 Nanocomposite-Based Polymeric Sensor for Potentiometric Estimation of Naltrexone Hydrochloride in Commercial Formulations

“…Furthermore, these materials are having extraordinary designs and unique optical characteristics that are not present in conventional composites [7]. Additionally, the nanocomposite synthesis is considered to be the main step in construction of various electronic devices [8], drug delivery systems [9], biomedical and immunosensing applications [10,11].…”