Development of tilapia collagen and chitosan composite hydrogels for nanobody delivery

Fan, Xiying; Liang, Yunlong; Cui, Yanshan; Li, Fēi; Sun, Yue; Yang, Junqing; Song, Haipeng; Bao, Zixian; Nian, Rui

doi:10.1016/j.colsurfb.2020.111261

Cited by 12 publications

(9 citation statements)

References 46 publications

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“…Kolagen yang diekstraksi dari ikan memiliki keunggulan karena mampu mengurangi penggunaan gelatin yang berasal dari babi dikarenakan babi dianggap haram oleh suku atau etnis tertentu [10]. Ekstraksi kolagen dari tulang ikan, atau sisik ikan merupakan produk samping atau limbah yang dapat digunakan sebagai bahan baku gelatin [11]. Kulit atau tulang ikan nila memiliki kandungan kolagen yang tinggi [12].…”

Section: Teoriunclassified

Pembuatan Gelatin dari Tulang Ikan Nila (Oreochromis niloticus) Menggunakan Metode Asam untuk Pengental Sirup Nanas

Wardhana

Sugiharto

2022

J. Teknik Kimia

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Imports of gelatin in Indonesia have increased according to demand. Gelatin is a protein derivative from collagen fibers derived from bone extraction. Gelatin contains protein, water and minerals. Gelatin is used to thicken, concentrate, and stabilize fluids such as water, acetic acid, and alcohol. The raw material used in the study was tilapia bone due to the lack of utilization of tilapia bone waste treatment. The purpose of this study was to examine the effect of sulfuric acid concentration on gelatin yield and to apply gelatin as a thickener for pineapple syrup. The methods are degreasing, extraction, and application of pineapple syrup. Variations in the concentration of H2SO4 were 1%, 3%, 5%, and variations in immersion time were 10 hours, 24 hours, and 36 hours. The analysis carried out on tilapia bone gelatin consisted of yield, acidity (pH) and viscosity. The best yield was produced using 1% H2SO4 and 10 hours immersion, which was 13.77%. The largest pH was produced at 2.47 with the use of 5% H2SO4 and immersion for 24 hours, and the largest viscosity was produced at 7.66 cP with the use of 5% H2SO4 and immersion for 36 hours.

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Section: Teoriunclassified

Pembuatan Gelatin dari Tulang Ikan Nila (Oreochromis niloticus) Menggunakan Metode Asam untuk Pengental Sirup Nanas

Wardhana

Sugiharto

2022

J. Teknik Kimia

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“…Também, hidrogéis à base de quitosana têm sido amplamente estudados devido à sua preparação simples, boa biocompatibilidade e reparabilidade em condições fisiológicas para administração (XU et al, 2019). Fan et al (2020) desenvolveram hidrogéis preparados a partir de colágeno reticulado de pele de tilápia (Oreochromis niloticus) e quitosana para entrega de nanocorpos. Os resultados indicaram a viabilidade da quitosana na entrega de medicamentos, potencializando sua utilização para usos na terapia do câncer.…”

Section: [393]unclassified

MINI-REVISÃO FOCADA NAS APLICAÇÕES BIOTECNOLÓGICAS DA QUITOSANA: EMBALAGENS, ALIMENTOS & BEBIDAS

Melo¹,

da²,

Silva³

et al. 2020

Ciência, Tecnologia E Inovação: Do Campo À Mesa

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“…In vivo , chitosan does not induce allergic reactions or rejection and can be metabolized into harmless monosaccharides absorbed by the human body. 17 , 18 Many active amino groups in the molecules are easily cleaved in the low pH tumor microenvironment. As a result of its bioadhesive, biodegradable, and pH-responsive nature, CS is a good option for DDS.…”

Section: Introductionmentioning

confidence: 99%

Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma

Chen

Hong

Duan

et al. 2022

Cancer Biology & Therapy

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Conventional clinical monotherapies for advanced hepatocellular carcinoma (HCC) have numerous limitations. Integrated oncology approaches can improve cancer treatment efficacy, and photothermal-chemotherapy drug delivery nanosystems (DDS) based on nanotechnology and biotechnology have piqued the interest of researchers. This study developed an aptamer-modified graphene quantum dots (GQDs)/magnetic chitosan DDS for photothermal-chemotherapy of HCC. The HCC aptamer and the EPR effect of nanoparticles, in particular, enable active and passive targeting of DDS to HCC. GQDs functioned as photosensitizers, effectively moderating photothermal therapy and inhibiting drug release during blood circulation. Magnetic chitosan demonstrated excellent drug encapsulation, acid sensitivity, and tumor imaging capabilities. Proper assembly of the units mentioned above enables precise combined therapy of HCC. This study indicates that DDS can significantly inhibit tumor growth while also extending the survival duration of tumor-bearing mice. The DDS (DOX-Fe 3 O 4 @CGA) shows strong synergistic tumor treatment potential, allowing for the exploration and development of novel HCC therapies.

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Development of tilapia collagen and chitosan composite hydrogels for nanobody delivery

Cited by 12 publications

References 46 publications

Pembuatan Gelatin dari Tulang Ikan Nila (Oreochromis niloticus) Menggunakan Metode Asam untuk Pengental Sirup Nanas

Pembuatan Gelatin dari Tulang Ikan Nila (Oreochromis niloticus) Menggunakan Metode Asam untuk Pengental Sirup Nanas

MINI-REVISÃO FOCADA NAS APLICAÇÕES BIOTECNOLÓGICAS DA QUITOSANA: EMBALAGENS, ALIMENTOS & BEBIDAS

Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma

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