Graphene quantum dots mediated magnetic chitosan drug delivery nanosystems for targeting synergistic photothermal-chemotherapy of hepatocellular carcinoma

Chen, Lili; Hong, Wenzhong; Duan, Siliang; Li, Yiping; Wang, Jian; Zhu, Jianmeng

doi:10.1080/15384047.2022.2054249

Cited by 30 publications

(17 citation statements)

References 31 publications

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“…Many types of bioactive macromolecules including oligonucleotides, aptamers, antibody, , peptides, and proteins have also been used to modify CS for targeted delivery. Targeting peptides or proteins with reactive carboxylic groups could be conjugated to C2-NH 2 of CS .…”

Section: Modification Of Cs With Versatile Biofunctions For Cancer Di...mentioning

confidence: 99%

Chemical Modification of Chitosan for Developing Cancer Nanotheranostics

Wang

Feng

et al. 2022

Biomacromolecules

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Cancer is a worldwide public health issue that has not been conquered. Theranostics, the combination of a therapeutic drug and imaging agent in one formulation using nanomaterials, has been developed to better cure cancer in recent years. Although diverse biomaterials have been applied in cancer theranostics, chitosan (CS), a natural polysaccharide bearing easy modification sites with excellent biocompatibility and biodegradability, shows great potential for developing cancer nanotheranostics. In this review, we seek to describe the chemical functionalities of CS used in cancer theranostics and their synthesis methods. We also present recent discoveries and research progresses on how the CS functionalization could improve the delivery efficiency of CS-based nanotheranostics. Finally, we report several case studies about the application of CS-based nanotheranostics. This paper focuses on the strategies to construct CS-based theranostics systems via chemical routes and highlights their applications in cancer treatment, which can provide useful references for further studies.

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Section: Modification Of Cs With Versatile Biofunctions For Cancer Di...mentioning

confidence: 99%

Chemical Modification of Chitosan for Developing Cancer Nanotheranostics

Wang

Feng

et al. 2022

Biomacromolecules

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“…These unique physicochemical properties endow GQDs with excellent potential in tumor therapy. Chen et al ( 47 ) combined aptamer-modified GQDs with magnetic chitosan to form novel photothermal-chemotherapy drug delivery nanosystems (DOX-Fe 3 O 4 @CGA). The results of an in vivo antitumor experiment showed that under NIR laser irradiation, the temperature of the tumor site in mice increased rapidly to 43–45°C, and the tumor volume and weight significantly decreased over time.…”

Section: Classification Of Photothermal Nanomaterialsmentioning

confidence: 99%

Research Progress of Photothermal Nanomaterials in Multimodal Tumor Therapy

et al. 2022

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The aggressive growth of cancer cells brings extreme challenges to cancer therapy while triggering the exploration of the application of multimodal therapy methods. Multimodal tumor therapy based on photothermal nanomaterials is a new technology to realize tumor cell thermal ablation through near-infrared light irradiation with a specific wavelength, which has the advantages of high efficiency, less adverse reactions, and effective inhibition of tumor metastasis compared with traditional treatment methods such as surgical resection, chemotherapy, and radiotherapy. Photothermal nanomaterials have gained increasing interest due to their potential applications, remarkable properties, and advantages for tumor therapy. In this review, recent advances and the common applications of photothermal nanomaterials in multimodal tumor therapy are summarized, with a focus on the different types of photothermal nanomaterials and their application in multimodal tumor therapy. Moreover, the challenges and future applications have also been speculated.

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“…Chen et al prepared an aptamer-modified GQD/chitosan nanodrug delivery system (DDS) for photothermal therapy of liver cancer, which can target hepatocellular carcinoma, significantly inhibit tumor growth in mice, and prolong the survival time of tumor-bearing mice, with good prospects for collaborative tumor treatment. 270 Yoosefian and colleagues reported a drug-delivery system using GQDs as a carrier to load the anticancer drug docetaxel (DTX). This system has good stability, and the presence of copolymers delays drug adsorption and increases the adsorption and solubility of DTX.…”

Section: Biological Applications Of Quantum Dotsmentioning

confidence: 99%