Development of hydrocortisone succinic acid/and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries

A novel green gelatin–agar microencapsulation system with P. urinaria as an improved anti-A. niger model

“…Microencapsulation is a micro-packaging technique used for microcapsule production by surrounding small particles of solids, droplets of liquids or dispersions of solids in liquids within polymer coatings to give small capsules useful for various applications (Lam, Gambari, et al, 2012;Lam, Lee, Kok, et al, 2012;Lam, Lee, Wong, et al, 2012;. Gelatin, as a biodegradable polymer, is required a crosslinker formaldehyde to improve the general properties of microcapsules Huang, Cheng, Yu, Tsai, & Cham, 2007).…”

Controlled release of active agents from microcapsules embedded in textile structures

“…In a study of Lam et al, was encapsulated in chitosan microcapsules and subsequently applied to a cotton fabric to a create transdermal delivery vehicle (Lam et al, 2012); 5-fluorouracil (5-fluoro-1H-pyrimidine-2,4-dione) was chosen for its effective cytotoxic activity in the topical treatment of various forms of skin cancers. Chitosan, a readily available biodegradable and biocompatible biopolymer, has been successfully used in fabrication of microcapsules intended for oral or topical medications.…”

“…11 Nude mice skin experiment was performed to demonstrate the possible delivery of 5-FU from microcapsule-fabricated cotton: (a) nude mouse; (b) nude mouse skin treated with microcapsule-fabricated cotton samples (right-hand side: 5-FU microcapsules treated cotton; left-hand side: blank microcapsules treated cotton); (c) nude mouse skin treated with microcapsule-fabricated cotton after 24 h; (d) release of 5-FU from microcapsule-fabricated cotton after 24 h. For (b) and (c), the left sample represents the microcapsule without drugs and the right sample represents the 5-FU-loaded microcapsules(Lam et al, 2012).…”

Design of an Inflammation-Sensitive Polyelectrolyte-Based Topical Drug Delivery System for Arthritis

“…In addition, nanoparticulate drug delivery systems improve patient compliance by minimizing drug dosage frequency as well as providing novel and innovative treatment, facilitating targeted drug delivery and controlled release (5). There are several reports suggesting the efficiency of nanoformulation for topical drug delivery applications (6)(7)(8). Various nanoparticles were reported to be effective for the administration of anti-inflammatory drugs for the treatment of dermatitis as well as rheumatoid arthritis (9)(10)(11)(12).…”