2015
DOI: 10.1208/s12249-015-0434-6
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Design of an Inflammation-Sensitive Polyelectrolyte-Based Topical Drug Delivery System for Arthritis

Abstract: Abstract. The most successful treatment strategy for arthritis is intra-articular injections that are costly and have reduced patient compliance. The purpose of the current study was to develop an inflammationsensitive system for topical drug administration. Multi-macromolecular alginate-hyaluronic acid-chitosan (A-H-C) polyelectrolyte complex nanoparticles, loaded with indomethacin were developed employing pre-gel and post-gel techniques in the presence of dodecyl-L-pyroglutamate (DLP). In addition to in vitr… Show more

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Cited by 15 publications
(8 citation statements)
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“…The MMER analysis provided an excellent insight into the composition of the nanostructured system wherein the alginate chains carried the drug molecule, hyaluronic acid provided proposed inflammation sensitive coating over the carrier molecule, and finally chitosan acted as the bridging agent to congeal the anionic molecules together—forming a stable and functional TPIQ architecture. Interestingly, HYA (being amphi‐ionic) provided the much needed ionic balance within the TPIQ and hence the formation of a well‐connected 3D architecture supported by extensive H‐bonding among the bimolecular (ALG:CHT, CHT‐HYA, and HYA:ALG) and trimolecular (ALG‐CHT‐HYA) regions and involved –COOH/‐COOH, –OH/–OH, –NH/–OH, –OCO–OH, –COOH–OH, and –COOH/–NH functional groups (Figure ) . The above discussion clearly confirms the important role played by amphi‐ionic or amphoteric systems in generation of effective polyelectrolyte complexes for biomedical applications.…”
Section: Molecular Interactions Inherent To Polyelectrolyte Complexesmentioning
confidence: 98%
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“…The MMER analysis provided an excellent insight into the composition of the nanostructured system wherein the alginate chains carried the drug molecule, hyaluronic acid provided proposed inflammation sensitive coating over the carrier molecule, and finally chitosan acted as the bridging agent to congeal the anionic molecules together—forming a stable and functional TPIQ architecture. Interestingly, HYA (being amphi‐ionic) provided the much needed ionic balance within the TPIQ and hence the formation of a well‐connected 3D architecture supported by extensive H‐bonding among the bimolecular (ALG:CHT, CHT‐HYA, and HYA:ALG) and trimolecular (ALG‐CHT‐HYA) regions and involved –COOH/‐COOH, –OH/–OH, –NH/–OH, –OCO–OH, –COOH–OH, and –COOH/–NH functional groups (Figure ) . The above discussion clearly confirms the important role played by amphi‐ionic or amphoteric systems in generation of effective polyelectrolyte complexes for biomedical applications.…”
Section: Molecular Interactions Inherent To Polyelectrolyte Complexesmentioning
confidence: 98%
“…Color codes for elements in (a): carbon (cyan), hydrogen (white), nitrogen (blue), and oxygen (red). Color codes for structures in (b): alginate (red), chitosan (blue), and hyaluronic acid (yellow) (Reference ; reproduced with permission from springer nature © 2015)…”
Section: Molecular Interactions Inherent To Polyelectrolyte Complexesmentioning
confidence: 99%
“…One of the pioneered inflammation-responsive polymeric drug delivery systems described were biodegradable hydrogels of cross-linked hyaluronic acid (HA), which specifically degrades in the presence of hydroxyl radicals (Nobuhiko et al, 1992). Since then, different architectures based on HA have been used with this aim (Nobuhiko et al, 1993;Bijukumar et al, 2016). More recently, other redox-responsive polymers have also been exploited for targeting inflammatory areas or for treating inflammation-related diseases reducing local oxidative stress.…”
Section: H a P T E Rmentioning
confidence: 99%
“…These inflammation-sensitive polymeric systems have been designed for different applications such as drug delivery systems (Mountziaris et al, 2011;Zhang et al, 2015b;Lee et al, 2015;Li et al, 2017;Nobuhiko et al, 1993;Bijukumar et al, 2016) for the treatment of inflammation-related diseases such as atherosclerosis, ischemia, rheumatoid arthritis, coronary artery disease, IBD, or, the most studied one, cancer. Moreover, bioactive films based on these kinds of polymers have been used as implant coatings to reduce the so-called foreign body reaction to implanted biomaterials (Kim et al, 2011;Wu et al, 2015;Mercanzini et al, 2010).…”
Section: H a P T E Rmentioning
confidence: 99%
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