“…DP, similar to other carbapenems, was developed for the treatment of hospitalised patients with moderate or severe bacterial infections (Jones et al, 2004) Doripenem has been determined in its pharmaceutical formulation and in plasma using different techniques, including spectrophotometry (Piontek and Ska, 2010) chromatography High Performance Liquid Chromatography (HPLC) with various detection methods (Sutherland and Nicolau, 2007;Ikeda et al, 2008) and liquid chromatography (Dailly et al, 2011;Ohmori et al, 2011). The development and application of ion-selective electrodes for pharmaceutical analysis continue to be of interest because these sensors offer the advantage of simple design and operation, reasonable selectivity, fast response, applicability to coloured and turbid solutions and possible interface with automated and computerised systems (Santini et al, 2008). For these advantages, ISEs have found various applications: in clinical chemistry, environmental protection, water, soil and analytical chemistry in general (Kormosh et al, 2008).…”