A New Potentiometric Sensor for Determination of Pethidine hydrochloride in Ampoules and Urine

Abstract

A simple, precise, rapid and low-cost potentiometric method for pethidine determination in pharmaceuticals and urine is proposed. A chemically modified carbon paste electrode (CMCPE) for pethidine hydrochloride (PDCl) based on pethidine-phosphotungstate (PD-PT) as ion-pair complex was prepared and fully character-ized in terms of composition, usable pH range, response time and temperature. The pethidine electrode showed Nernstain responses in the concentration range 2.1 × 10–6-1.0 × 10–2 M with a detection limit of 7.3 × 10-7 and usable within the pH range 3.5-6.6. This sensor exhibited a fast response time (about 5-8 s), good stability. The value (dE/dt) of the electrode was found to be 0.00071 V/?C, which indicates fairly high ther-mal stability. Selectivity coefficients determined by matched potential method (MPM) and separate solution method (SSM) showed high selectivity for PDCl with respect to a large number of inorganic cations, organic cations, sugars and some common drug excipients. The sensor could be used successfully in the estimation of PDCl in ampoules and in spiked urine samples

Ultrasensitive functionalized CeO2/ZnO nanocomposite sensor for determination of a prohibited narcotic in sports pethidine hydrochloride

“…Therefore, the determination of pethidine has significant practical implications. Numerous sophisticated analytical approaches exist for the determination of pethidine, including high-performance liquid chromatographic analyzes [ [9] , [10] , [11] , [12] ], spectroscopic methods [ 13 ], and electrochemical and potentiometric methods [ [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] ]. Numerous of these techniques require various elaborate manipulations, extraction steps, and derivatization reactions that are susceptible to a variety of interferences and are not suitable for colored or turbid solutions.…”

“…Several sensors have been developed for the determination of pethidine hydrochloride, but they still have certain limitations. A recipe is clearly needed for the preparation and development of potentiometric sensors with low detection limits, high stability and reproducibility [ [14] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] ].…”

Potentiometric sensors for the determination of pharmaceutical drugs

“…Their response times were found to be 10 and 16 s, and their lifetimes were about 8 weeks. They have compared the outcomes with those estimated employing the standard official method and noticed similar performance utilizing both techniques.For the detection of pethidine hydrochloride (PDH) in injection dosage form as well as spiked urine samples, a chemically modified CPE (CMCPE) relied on PDH-phosphotungstate (PD-PT) as ion-pair complex was fabricated38 . This new sensor has exhibited Nerstian responses over the range of 2.1×10 -6 to 1.0×10 -2 M and operated effectively in the pH range of 3.5-6.6.…”