Development of a model of ischemic heart disease using cardiomyocytes differentiated from human induced pluripotent stem cells

Heng, Wei; Wang, Chen; Guo, Rui; Takahashi, Katsuroku; Naruse, Keiji

doi:10.1016/j.bbrc.2019.09.119

Cited by 15 publications

(5 citation statements)

References 13 publications

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“…Estudos in vitro simulando I/R já foram relatados (CHEN;VUNJAK-NOVAKOVIC, 2018;HIDALGO;GLASS;OVCHINNIKOV;YANG et al, 2018;WEI;WANG;GUO;TAKAHASHI et al, 2019). Resumidamente, a fim de mimetizar a isquemia, células cardíacas são mantidas em meio pobre em nutrientes a uma atmosfera de N2 ou mistura gasosa composta por 95% de N2 e 5% de CO2.…”

Section: Discussionunclassified

Estudo Do Envolvimento Dos Receptores Da Adenosina Sobre a Ação Cardioprotetora Da Espironolactona E Eplerenona Em Cardiomiócitos De Rato

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2020

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Section: Discussionunclassified

Estudo Do Envolvimento Dos Receptores Da Adenosina Sobre a Ação Cardioprotetora Da Espironolactona E Eplerenona Em Cardiomiócitos De Rato

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2020

BJD

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“…Furthermore, as the heart ages and the myocardium is released from the cell cycle, Hippo activity increases significantly, while YAP activity decreases considerably ( Heallen et al, 2013 ; von Gise et al, 2012 ) and cell proliferation is endogenously inhibited. In recent years, clinical trials of the new approach to stem cell transplantation have shown limited success, but long-term effectiveness remains unknown ( Wei et al, 2019 ; Hotham and Henson, 2020 ; Schwach et al, 2020 ). NRG1 was found to promote mitosis through ErbB ( D'Uva et al, 2015 ) for efficient cell proliferation.…”

Section: Nrg1 With Cardiovascular Diseasesmentioning

confidence: 99%

Neuregulin-1, a potential therapeutic target for cardiac repair

et al. 2022

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NRG1 (Neuregulin-1) is an effective cardiomyocyte proliferator, secreted and released by endothelial vascular cells, and affects the cardiovascular system. It plays a major role in heart growth, proliferation, differentiation, apoptosis, and other cardiovascular processes. Numerous experiments have shown that NRG1 can repair the heart in the pathophysiology of atherosclerosis, myocardial infarction, ischemia reperfusion, heart failure, cardiomyopathy and other cardiovascular diseases. NRG1 can connect related signaling pathways through the NRG1/ErbB pathway, which form signal cascades to improve the myocardial microenvironment, such as regulating cardiac inflammation, oxidative stress, necrotic apoptosis. Here, we summarize recent research advances on the molecular mechanisms of NRG1, elucidate the contribution of NRG1 to cardiovascular disease, discuss therapeutic approaches targeting NRG1 associated with cardiovascular disease, and highlight areas for future research.

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“…The scores of all related items are summed to calculate the score of the questionnaire. Minimum and maximum scores in the areas of care in treatment (9-45), willingness to participate in treatment , ability to adapt , integration of treatment with life (5-25), clinging to treatment (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), commitment to treatment , and prudence in the implementation of treatment (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15) are calculated. The total score range of the questionnaire is from 40 to 200.…”

Section: Research Tools Treatment Adherence Questionnaire (Taq)mentioning

confidence: 99%

The Impact of Intervention Based on Protection Motivation Theory on Treatment Adherence in Patients with Ischemic Heart Disease

Zakipoor

Hajalizadeh

Seirafi

et al. 2022

Hormozgan medical journal

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Background: Patients with ischemic heart disease (IHD) gradually reduce their follow-up treatment due to the vulnerable physical condition and high involvement with the disease-related treatment process. The purpose of this research was to investigate the effect of intervention based on the protection motivation theory (PMT) on treatment adherence in patients with IHD. Methods: This quasi-experimental research used a pretest-posttest design with a control group. The statistical population included all patients with IHD referred to the Payambar Azam hospital in Bandar Abbas, Iran for more than once between March 2019 and May 2020. A total of 16 patients were selected through the matched targeted sampling and randomly assigned into two equal groups of experimental and control (n = 8 each). The test group received an intervention based on the PMT in six 90-minute sessions within 45 days. We used the Modanloo Treatment Adherence Questionnaire (TAQ), and the data were analyzed using the analysis of covariance (ANCOVA) in the SPSS23 statistical software. Results: The results of ANCOVA showed that the intervention based on the PMT significantly increased the treatment adherence and its subscales in patients with IHD (P<0.001). Conclusion: Intervention based on the PMT can be used as an effective intervention to increase treatment adherence in patients with IHD, depending on proper nutrition training, self-care skills, awareness-raising, and relaxation exercises.

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Development of a model of ischemic heart disease using cardiomyocytes differentiated from human induced pluripotent stem cells

Cited by 15 publications

References 13 publications

Estudo Do Envolvimento Dos Receptores Da Adenosina Sobre a Ação Cardioprotetora Da Espironolactona E Eplerenona Em Cardiomiócitos De Rato

Estudo Do Envolvimento Dos Receptores Da Adenosina Sobre a Ação Cardioprotetora Da Espironolactona E Eplerenona Em Cardiomiócitos De Rato

Neuregulin-1, a potential therapeutic target for cardiac repair

The Impact of Intervention Based on Protection Motivation Theory on Treatment Adherence in Patients with Ischemic Heart Disease

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