Estudo Do Envolvimento Dos Receptores Da Adenosina Sobre a Ação Cardioprotetora Da Espironolactona E Eplerenona Em Cardiomiócitos De Rato

Faria, Gabriela de Oliveira

doi:10.34117/bjdv6n8-292

Cited by 1 publication

(1 citation statement)

References 23 publications

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“…The cardioprotective action of the molecules isoscutelarein A and hypolaetin A was suggested (Table 1). The cardioprotective action can help reduce damage to the heart muscle, improving cardiovascular health, potentially preventing serious complications as heart attacks (Faria et al, 2020). In addition to the activities mentioned, the substances isoscutelarein A and hypolaetin A were suggested to have antioxidant activity by eliminating free radicals (Table 1).…”

Section: Prediction Of Biological Activitiesmentioning

confidence: 99%

Biological activity an in silico toxicity of phenolic compounds found in cupuaçu seed (Theobroma grandiflorum)

Ferreira,

Crispim,

Aguiar

et al. 2024

RSD

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Cupuaçu (Theobroma grandiflorum) from the Malvaceae family, has seeds rich in flavonoids. The biological activities of seeds are diverse, however, there are scarce data on these metabolites. The study aimed to evaluate, through in silico methods, the biological, toxicological, and pharmacokinetic potential of metabolites present in the cupuaçu seed. The metabolites hypolaetina 3'-methylether 8-O-β-D glucuronide, theograndin II, hypolaetina 3'-methylether 8-O-β-D 3”-sulfated glucuronide, isoscutellarein 8-0-β-D glucuronide and theograndin I were analysed through Pubchem to search for structures, and PreADMET (pharmacokinetics and toxicity) and PASS online for biological activities (PA >98%). The results demonstrated low human intestinal absorption, in addition to weak to moderate distribution across the blood-brain barrier. All phenolic compounds showed weak to moderate binding to plasma proteins and low permeability in CaCo2 cells, except for isoscutelarein 8-0-β-D glucuronide and hypolaetina 3'-methylether 8-O-β-D glucuronide with moderate permeability, being non-mutagenic. Furthermore, they had the potential to inhibit CYPs, such as CYP-2C9 and CYP-3A4. Also, the structures showed toxicity in Medaka fish, but they did not present toxicity in algae and Daphnia sp. Finally, the molecules presented the following main properties: hemostatic, cardioprotective, and antioxidant action, among others. The compounds presented varied biological activity profiles, but their pharmacokinetic and toxicity were not promising, limiting the potential for developing new drugs. The use of technologies is suggested to transform them into prodrugs, carriers, and the use of molecular modeling.

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Section: Prediction Of Biological Activitiesmentioning

confidence: 99%

Biological activity an in silico toxicity of phenolic compounds found in cupuaçu seed (Theobroma grandiflorum)

Ferreira,

Crispim,

Aguiar

et al. 2024

RSD

View full text Add to dashboard Cite

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Estudo Do Envolvimento Dos Receptores Da Adenosina Sobre a Ação Cardioprotetora Da Espironolactona E Eplerenona Em Cardiomiócitos De Rato

Abstract: Estudo do envolvimento dos receptores da adenosina sobre a ação cardioprotetora da espironolactona e eplerenona em cardiomiócitos de rato Study of the involvement of adenosine receptors on the cardioprotective action of spironolactone and eplerenone in rat cardiomyocytes

Cited by 1 publication

References 23 publications

Biological activity an in silico toxicity of phenolic compounds found in cupuaçu seed (Theobroma grandiflorum)

Biological activity an in silico toxicity of phenolic compounds found in cupuaçu seed (Theobroma grandiflorum)

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