Development and validation of a gas chromatographic–mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration

Turunen, Elina; Lehtonen, Marko; Järvinen, Tomi; Jarho, Pekka

doi:10.1016/j.jchromb.2008.07.010

Cited by 12 publications

(3 citation statements)

References 33 publications

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“…In order to determine perphenazine (PPZ) dosage in preparations and its concentration in diverse matrices such as plasma, urine, and environmental waste waters, different analytical methods including spectrophotometry, [1][2][3][4] electrochemical, [5][6][7][8] high-performance liquid chromatography (HPLC), [9][10][11][12] gas chromatography mass spectrometry (GC-MS), 13,14 and capillary electrophoresis 5,15,16 have been introduced. In most cases, separation and preconcentration of PPZ is required prior to analysis.…”

Section: Introductionmentioning

confidence: 99%

Pre-Concentration and Separation of Perphenazine Using Picric Acid Loaded α-Fe2O3 Nanoparticles: HPLC Syringe Filter as the Particles Support

Ramezani

Shekarriz

Behfar

et al. 2017

J. Braz. Chem. Soc.

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Suspension of picric acid (PA) loaded iron oxide nanoparticles (PA-IONPs) was injected on the top of a 0.2 µm HPLC (high-performance liquid chromatography) syringe filter. The immobilized nanoparticles were used as SPE (solid phase extraction) sorbent for perphenazine separation and pre-concentration. By passing perphenazine solution through the filter, a molecular complex between perphenazine and PA was formed. Perphenazine/PA complex was eluted from the filter using dichloromethane as solvent. The perphenazine contents were determined at 254 nm. Effects of the parameters such as pH, the amount of PA-IONPs, as well as flow rate, volume, and type of eluting solvents, on the separation efficiency and pre-concentration of perphenazine were investigated. The calibration curve was linear in the range of 0.5-5 ng mL -1 (Y = 0.047X + 0.018; R 2 = 0.9952) with limit of detection of 0.16 ng mL -1. The pre-concentration and enrichment factors were 8.33 and 1.88, respectively. This method was successfully applied to the determination of perphenazine residue in tap water.

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Section: Introductionmentioning

confidence: 99%

Pre-Concentration and Separation of Perphenazine Using Picric Acid Loaded α-Fe2O3 Nanoparticles: HPLC Syringe Filter as the Particles Support

Ramezani

Shekarriz

Behfar

et al. 2017

J. Braz. Chem. Soc.

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show abstract

“…6,7 Due to these functions and applications, up to now, some detection methods have been reported for the determination of perphenazine. These methods include high-performance liquid chromatography, 8,9 gas chromatography, [10][11][12] chemiluminescence, 13 spectrophotometry [14][15][16] and titrimetry. [17][18][19] However, few studies on the electrochemical behavior of this drug have been reported.…”

Section: Introductionmentioning

confidence: 99%

Electrooxidation and determination of perphenazine on a graphene oxide nanosheet-modified electrode

2015

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The electrochemical behavior of perphenazine was investigated on a graphene oxide nanosheet-modified glassy carbon electrode in a phosphate buffer solution at pH 7.4. Cyclic voltammetry was employed to study the drug electrooxidation process. Perphenazine was electrooxidized on the modified electrode surface at lower potentials with a higher rate through an irreversible process. The kinetic parameters of the electrooxidation reaction, including the standard rate constant as well as diffusion and charge transfer coefficients were obtained. Amperometric and differential pulse voltammetric procedures were developed for the determination of perphenazine. Linear dynamic ranges of 0.8-8.0 and 0.7-7.0 mmol L À1 with calibration sensitivities of 35.23 and 36.54 mA mol À1 L cm À2 and detection limits of 46.6 and 38.4 mmol L À1 were obtained using amperometry and differential pulse voltammetry, respectively.The amperometric method was applied in the analysis of perphenazine tablets, and the applicability of the method for the direct assays of spiked human serum, urine and breast milk fluids was investigated.

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“…Some efforts have been made over the last several decades to develop a simple, reliable and sensitive method for the determination of PPZ in pharmaceuticals and biological samples. Though for the good selectivity of high performance liquid chromatography [7][8][9][10][11] and gas chromatography-mass spectroscopy [12][13][14] methods, costly apparatus are needed and the experimental conditions are greatly affected by environmental factors. Spectrophotometric methods have also been applied to determine PPZ content, however the sensitivity of these methods is poor.…”

Section: Introductionmentioning

confidence: 99%

Highly sensitive determination of perphenazine on a carbon nanocomposite ionic liquid electrode

2015

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Development and validation of a gas chromatographic–mass spectrometric method for quantitative determination of perphenazine in rabbit plasma after sublingual administration

Cited by 12 publications

References 33 publications

Pre-Concentration and Separation of Perphenazine Using Picric Acid Loaded α-Fe2O3 Nanoparticles: HPLC Syringe Filter as the Particles Support

Pre-Concentration and Separation of Perphenazine Using Picric Acid Loaded α-Fe2O3 Nanoparticles: HPLC Syringe Filter as the Particles Support

Electrooxidation and determination of perphenazine on a graphene oxide nanosheet-modified electrode

Highly sensitive determination of perphenazine on a carbon nanocomposite ionic liquid electrode

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