A multi-walled carbon nanotube–ionic liquid nanocomposite was fabricated for the electrochemical detection of perphenazine, suitable for the analysis of pharmaceuticals and blood serum samples.
Background:
Piroxicam is a non-steroidal anti-inflammatory drug. The prevailing clinical
use and investigation of piroxicam necessitate a rapid and sensitive method for its determination. A
carbon ionic liquid electrode, fabricated using graphite and the ionic liquid 1-octylpyridinium
hexafluorophosphate (OPFP) was used as an electrochemical sensor for piroxicam determination.
Methods:
The surface of the proposed electrode was characterized by scanning electron microscopy.
Cyclic voltammetry (CV) was applied to study the oxidation of piroxicam and to acquire information
about the reaction mechanism. Differential pulse voltammetry was also used as an analytical technique
for quantification of the sub-micromolar concentration of piroxicam.
Results:
One oxidation peak at 0.55V was observed at CILE. The oxidation peak at the CPE was weak,
while the response was notably increased at the CILE. The proposed electrode exhibited interesting
sensitivity towards the determination of piroxicam and the anodic peak current versus piroxicam concentration
was linear in the ranges of 0.2-60 µM. The detection limit of 40 nM was achieved.
Conclusion:
The electroxidation process was irreversible and revealed adsorption controlled behavior.
The method was successfully applied for the determination of piroxicam content in pharmaceutical
samples.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.