Development and evaluation of colloidal modified nanolipid carrier: Application to topical delivery of tacrolimus

Pople, Pallavi V.; Singh, Kamalinder K.

doi:10.1016/j.ejpb.2011.02.016

Cited by 99 publications

(48 citation statements)

References 38 publications

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“…Furthermore, it also well said that higher bioavailability and less irritating in guinea pig as compared to commercial ointment and have sufficient stability [71] De Nova pathways and DNA…”

Section: Role Of Nanomedicines In Effective Drug Therapy Of Psoriasismentioning

confidence: 96%

Nanomedicine-based drug targeting for psoriasis: potentials and emerging trends in nanoscale pharmacotherapy

Rahman¹,

Akhter²,

Ahmad

et al. 2014

Expert Opinion on Drug Delivery

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Novel nanomedicines (such as liposomes, polymeric nanoparticles, etc.) have shown their potential in improving therapeutic benefits of antipsoriatic drugs by increasing their therapeutic efficacy with minimal toxicity. Nevertheless, while the results on animal models using nanomedicine-based drug targeting of psoriasis via different route seem promising, lack of sufficient evidence in a clinical setup is a constraint and more clinical studies on the efficacy and safety of nanomedicines in psoriasis therapy are required.

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“…Furthermore, it also well said that higher bioavailability and less irritating in guinea pig as compared to commercial ointment and have sufficient stability [71] De Nova pathways and DNA…”

Section: Role Of Nanomedicines In Effective Drug Therapy Of Psoriasismentioning

confidence: 96%

Nanomedicine-based drug targeting for psoriasis: potentials and emerging trends in nanoscale pharmacotherapy

Rahman¹,

Akhter²,

Ahmad

et al. 2014

Expert Opinion on Drug Delivery

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“…Modified NLCs for topical delivery of tacrolimus (T-MNLC) in the therapy of atopic dermatitis and other skin inflammation disorders have been shown to enable high entrapment efficiency of the poorly soluble drug, enhanced stability and improved skin deposition [138]. In vivo evaluation of T-MNLC based on restoration of skin barrier, therapeutic effectiveness and safety aspects imply the potential of developed formulation in the therapy of atopic dermatitis [139].…”

Section: Nanostructured Lipid Carriers (Nlcs)mentioning

confidence: 99%

(Phospho)lipid-based Nanosystems for Skin Administration

Vanić¹,

Holæter²,

Škalko‐Basnet

2015

CPD

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Nanotechnology and nanomedicine provide a platform for advanced therapeutic strategies for dermal and transdermal drug delivery. The focus of this review is on the current state-of-art in lipid-based nanotechnology and nanomedicine for (trans)dermal drug therapy. Drug delivery nanosystems based on the (phospho)lipid constituents are characterized and compared, with the emphasis on their ability to assure the controlled drug release to the skin and skin appendages, drug targeting and safety. Different types of liposomes, biphasic vesicles, particulate lipid-based nanosystems and micro-and nano-emulsions are discussed in more details. Extensive research in preclinical studies has shown that numerous parameters including the composition, size, surface properties and their combinations affect the deposition and/or penetration of carrier-associated drug into/through the skin, and consequently determine the therapeutic effect. The superiority of the most promising nanopharmaceuticals has been confirmed in clinical studies. We have selected several common skin disorders and provided overview over promises of nanodermatology in antimicrobial skin therapy, anti-acne treatment, skin oncology, gene delivery and vaccines. We addressed the potential toxicity and irritation issues and provided an overview of registered lipid-based products

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“…There are several reports suggesting the efficiency of nanoformulation for topical drug delivery applications (6)(7)(8). Various nanoparticles were reported to be effective for the administration of anti-inflammatory drugs for the treatment of dermatitis as well as rheumatoid arthritis (9)(10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

Design of an Inflammation-Sensitive Polyelectrolyte-Based Topical Drug Delivery System for Arthritis

et al. 2015

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Abstract. The most successful treatment strategy for arthritis is intra-articular injections that are costly and have reduced patient compliance. The purpose of the current study was to develop an inflammationsensitive system for topical drug administration. Multi-macromolecular alginate-hyaluronic acid-chitosan (A-H-C) polyelectrolyte complex nanoparticles, loaded with indomethacin were developed employing pre-gel and post-gel techniques in the presence of dodecyl-L-pyroglutamate (DLP). In addition to in vitro studies, in silico simulations were performed to affirm and associate the molecular interactions inherent to the formulation of core all-natural multi-component biopolymeric architectures composed of an anionic (alginate), a cationic (chitosan), and an amphi-ionic polyelectrolytic (hyaluronic acid) macromolecule. The results demonstrated that DLP significantly influenced the size of the synthesized nanoparticles. Drug-content analysis revealed higher encapsulation efficiency (77.3%) in the presence of DLP, irrespective of the techniques used. Moreover, in vitro drug release studies showed that indomethacin release from the nanosystem was significantly improved (98%) in Fenton's reagent. Drug permeation across a cellulose membrane using a Franz diffusion cell system showed an initial surge flux (0.125 mg/cm −2 /h), followed by sustained release of indomethacin for the post-gel nanoparticles revealing its effective skin permeation efficiency. In conclusion, the study presents novel nanoparticles which could effectively encapsulate and deliver hydrophobic drugs to the target site, particularly for arthritis.

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Development and evaluation of colloidal modified nanolipid carrier: Application to topical delivery of tacrolimus

Cited by 99 publications

References 38 publications

Nanomedicine-based drug targeting for psoriasis: potentials and emerging trends in nanoscale pharmacotherapy

Nanomedicine-based drug targeting for psoriasis: potentials and emerging trends in nanoscale pharmacotherapy

(Phospho)lipid-based Nanosystems for Skin Administration

Design of an Inflammation-Sensitive Polyelectrolyte-Based Topical Drug Delivery System for Arthritis

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