Development and characterization of UV curable epoxy/hydroxyapatite suspensions for stereolithography applied to bone tissue engineering

Scalera, Francesca; Corcione, Carola Esposito; Montagna, Francesco; Sannino, Alessandro; Maffezzoli, Alfonso

doi:10.1016/j.ceramint.2014.06.117

Cited by 90 publications

(41 citation statements)

References 18 publications

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“…Several materials have been developed and analyzed to be used for this purpose, including bioactive ceramics such as hydroxyapatite (HA) [5], beta-tricalcium phosphate (b-TCP) [6], biphasic calcium phosphate (BCP) [7], calcium phosphate 2 International Journal of Polymer Science cements [8], bioactive glass [9], and several biodegradable polymers [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Effects of Genipin Concentration on Cross-Linked Chitosan Scaffolds for Bone Tissue Engineering: Structural Characterization and Evidence of Biocompatibility Features

Dimida

Barca

Cancelli

et al. 2017

International Journal of Polymer Science

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Genipin (GN) is a natural molecule extracted from the fruit of Gardenia jasminoides Ellis according to modern microbiological processes. Genipin is considered as a favorable cross-linking agent due to its low cytotoxicity compared to widely used cross-linkers; it cross-links compounds with primary amine groups such as proteins, collagen, and chitosan. Chitosan is a biocompatible polymer that is currently studied in bone tissue engineering for its capacity to promote growth and mineral-rich matrix deposition by osteoblasts in culture. In this work, two genipin cross-linked chitosan scaffolds for bone repair and regeneration were prepared with different GN concentrations, and their chemical, physical, and biological properties were explored. Scanning electron microscopy and mechanical tests revealed that nonremarkable changes in morphology, porosity, and mechanical strength of scaffolds are induced by increasing the cross-linking degree. Also, the degradation rate was shown to decrease while increasing the crosslinking degree, with the high cross-linking density of the scaffold disabling the hydrolysis activity. Finally, basic biocompatibility was investigated in vitro, by evaluating proliferation of two human-derived cell lines, namely, the MG63 (human immortalized osteosarcoma) and the hMSCs (human mesenchymal stem cells), as suitable cell models for bone tissue engineering applications of biomaterials.

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Section: Introductionmentioning

confidence: 99%

Effects of Genipin Concentration on Cross-Linked Chitosan Scaffolds for Bone Tissue Engineering: Structural Characterization and Evidence of Biocompatibility Features

Dimida

Barca

Cancelli

et al. 2017

International Journal of Polymer Science

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“…In addition, hydroxyapatite (HAp) is also exploited as a model compound to mimic the biomineralization process [21,22]. However, HA with particle size < 10 microns is classified as common inorganic filler used to improve the mechanical properties and biocompatibility of polymer composites [23][24][25][26][27][28][29], because of its excellent biocompatibility properties, non-toxic, non-immunog-enic and osteoconductive [23,[30][31][32][33][34]. It is similar to the silica powder used in polymer composites [35][36][37][38].…”

Section: Hydroxyapatite (Ha)mentioning

confidence: 99%

A Brief Review on Biomedical Applications of Hydroxyapatite Use as Fillers in Polymer

Majhooll¹,

Zainol²,

Jaafar³

et al. 2019

JCCE

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Preparation of hydroxyapatite (HA) through natural sources, such as fish scales or synthetic HA produced from the chemical reaction has been widely used as biomedical materials because HA is bioactive, non-toxic and osteoconductive with a crystallographic structure almost similar to that of the bone mineral. In addition, HAwith particle size < 10 microns is classified as common inorganic filler used to improve the mechanical properties and biocompatibility of polymer composites. The purpose of this review is to collect information related to HA, and to provide readers with information about synthesis methods, advantages of hydroxyapatite as biomaterial,biomedical applications of polymer/HA composites.

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“…However, the use of SLA for production of composite resin‐based materials is still challenging because of the difficulties associated to the increased viscosity of the system, the non‐homogenous distribution of the ceramic filler, and the UV intensity reduction due to light scattering . As biocompatible filler, hydroxyapatite (HAP) is attractive due to its similarity to human bone and teeth; however, HAP is characterized by a hydrophilic surface which prevents dispersion and adhesion with hydrophobic polymeric matrices, thus affecting the overall performance of composites. Coupling agents capable to promote the adhesion of HA with a polymer matrix can slow the HA degradation process, protect the filler against fracture, increase the resistance to hydrolytic degradation of composite, and improve the stress distribution at the interface between the flexible organic matrix to the stiffer inorganic filler particles .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial modified hydroxyapatite composite dental bite by stereolithography

Makvandi

Corcione

Paladini

et al. 2017

Polymers for Advanced Techs

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This study is aimed at the synthesis of antimicrobial hydroxyapatite (HAP)-based composites for dental application by stereolithography (SLA). A micron-sized commercial HAP was modified by methacrylate and quaternary ammonium salt, and, then, it was used in different amounts (namely 2.5, 5, and 10 wt%) as filler for a photocurable custom made resin for SLA.Thermal stability, microstructure, and particles size of the pristine (HAP) and modified HAP (mHAP) were evaluated by thermogravimetric analysis (TGA), X-ray diffraction (XRD), and particle size analyser (CILAS). The suitability of each formulation for stereolithography process was assessed by measuring viscosity, degree of conversion (DC%) by Fourier transform infrared spectroscopy (FTIR), glass transition temperature, and thermal stability. Photo-cured specimens for physical, mechanical, and antimicrobial testing were built by SLA. The flexural strength of the samples was measured using a 3-point bending test method, and the fractured surface was analysed by scanning electron microscopy (SEM). The antimicrobial activity of samples was investigated against some standard microorganisms (Staphylococcus aureus, Escherichia coli, and Candida albicans), as representative Gram positive and Gram negative bacteria and fungus, respectively. The flexural strength increased with a filler content up to 5% and slightly decreased for higher content. SEM analysis confirmed the presence of uniformly distributed HAP. The incorporation of mHAP reduced the bacterial and fungal growth in dose-dependent manner in comparison with the neat samples. Finally, a prototype of dental bite was built by SLA. KEYWORDSantibacterial, dental bite, quaternary ammonium, stereolithography

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Development and characterization of UV curable epoxy/hydroxyapatite suspensions for stereolithography applied to bone tissue engineering

Cited by 90 publications

References 18 publications

Effects of Genipin Concentration on Cross-Linked Chitosan Scaffolds for Bone Tissue Engineering: Structural Characterization and Evidence of Biocompatibility Features

Effects of Genipin Concentration on Cross-Linked Chitosan Scaffolds for Bone Tissue Engineering: Structural Characterization and Evidence of Biocompatibility Features

A Brief Review on Biomedical Applications of Hydroxyapatite Use as Fillers in Polymer

Antimicrobial modified hydroxyapatite composite dental bite by stereolithography

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