Development and Characterization of Novel Cellulose Composites Obtained in 1-Ethyl-3-methylimidazolium Chloride Used as Drug Delivery Systems

Spiridon, Iuliana; Andrei, Iuliana-Marilena; Anghel, Narcis; Dinu, Maria Valentina; Ciubotaru, Bianca-Iulia

doi:10.3390/polym13132176

Cited by 14 publications

(8 citation statements)

References 25 publications

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“…The pores are round and slit-like. The elasticity (ability of material to return to its original for and size after removal of deformation force) is very important property of soft drug formulations and cosmetic products [25][26][27]. As is known, the compression Young's moduli characterize a material's stiffness.…”

Section: Resultsmentioning

confidence: 99%

Deformation Properties of Hydrogel Compositesof Α-Lipoic Acid With Colloid Silica

2022

Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.

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Hydrogels are widely used as the basis of soft drug formulations and cosmetic compositions (ointments, creams, gels, masks, dermal fillers, etc.). Deformation properties of these products are very important from the point of view of the convenience and safety of their application, as well as optimization of their production process. In this work, inorganic silica hydrogels are considered as a promising basis for the development of new soft drug formulations and products for cosmetology. The hydrogel composites of colloid silica with α-lipoic acid which is a well-known powerful anti-oxidant used for treatment of various skin diseases were synthesized. Besides, the drug has a reju-venating effect on the skin. Taking into account the indicated potential application of the hydrogels and the methods of their administration (transdermal, injection), the hydrogels had a pH of 6.6-7.4. Pure silica hydrogels and their composites with α-lipoic acid were synthesized by a two-step sol-gel method. Using the method of optical microscopy, it was shown that they have a highly po-rous surface. The deformation properties of the synthesized hydrogels under compression, tension, and shear were determined. It is shown that the synthesized hydrogels have a certain elasticity under axial compression, thixotropy and exhibit pseudoplasticity. The effects ofthe synthesis con-ditions (concentration of the catalyst for silica sol formation, the amount of the introduced drug) on the deformation properties of the composites have been established. The effects were explained in terms of the influence of these factors on the strength of the three-dimensional silica framework of the hydrogel materials. The discovered deformation properties of silica hydrogels make them promising for the development of new soft drug formulations for topical application.

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Section: Resultsmentioning

confidence: 99%

Deformation Properties of Hydrogel Compositesof Α-Lipoic Acid With Colloid Silica

2022

Izv. Vyssh. Uchebn. Zaved. Khim. Khim. Tekhnol.

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“…According to V. Bartůněk et al, the recorded magnetic behavior makes cobalt ferrite–lignin hybrids promising candidates for medicinal applications [ 49 ]. Some authors [ 50 , 51 ] confirmed that ferrite lignin delays the release of ketokonazole from a polysaccharide-polyurethane matrix. Dai et al reported [ 52 ] on the synthesis of lignin nanoparticles and their further use as a green carrier for the sustained release of Resveratrol ® .…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Characterization of New Ferrite-Lignin Hybrids

Spiridon¹,

Dascalu²,

Coroabă³

et al. 2021

Polymers

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The paper presents the synthesis and characterization of new cobalt ferrite-lignin hybrids. The hybrids were obtained through the combustion of cobalt nitrate and ferric nitrate, two kinds of lignin being used as combustion agents. The temperatures of calcination were 500 °C and 900 °C, respectively. The hybrids were characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray powder diffraction (XRD), scanning electron microscopy (SEM), energy-dispersive X-ray (EDX), and X-ray photoelectron spectroscopy (XPS). The magnetic properties were also assessed by vibrating sample magnetometer system (VSM). This facile synthesis method made it possible to obtain cobalt ferrite-lignin hybrids with a spinel structure. Their particle sizes and crystallite sizes have increased with an increment in the calcination temperature. A different occupancy of cations at octahedral and tetrahedral sites also occurred upon the increase in temperature. The hybrids comprising organic lignin presented the best magnetic properties.

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“…An initial force of 0.1 N was applied before performing each measurement. The cross-head speed was 1 mm × min −1 , while the applied force was fixed at 20 N. The compressive stresses (σ, kPa), strains (ε), and elastic moduli (G, kPa) were evaluated at room temperature following the procedure previously published in [ 51 , 52 ].…”

Section: Methodsmentioning

confidence: 99%

Xanthan-Based Materials as a Platform for Heparin Delivery

et al. 2023

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Heparin (Hep), with its anticoagulant activity, antiangiogenic and apoptotic effects, and growth factor binding, plays an important role in various biological processes. Formulations as drug delivery systems protect its biological activity, and limit the potential side effects of faulty administration. The objective of this study was to develop novel xanthan-based materials as a delivery carrier for heparin. The materials exhibited remarkable elastic behavior and toughness without any crack development within the network, which also support their application for tissue engineering. It was found that all materials possessed the ability to control the release of heparin, according to the Korsmeyer–Peppas release model. All Hep-containing materials caused significant exchanges of the activated partial thromboplastin time (aPTT) and prothrombin time (PT) parameters, indicating that formulated natural/natural synthetic polymeric networks conserved heparin’s biological activity and its ability to interrupt the blood coagulation cascade. The obtained results confirmed that developed materials could be carriers for the controlled release of heparin, with potential applications in topical administration.

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Development and Characterization of Novel Cellulose Composites Obtained in 1-Ethyl-3-methylimidazolium Chloride Used as Drug Delivery Systems

Cited by 14 publications

References 25 publications

Deformation Properties of Hydrogel Compositesof Α-Lipoic Acid With Colloid Silica

Deformation Properties of Hydrogel Compositesof Α-Lipoic Acid With Colloid Silica

Synthesis and Characterization of New Ferrite-Lignin Hybrids

Xanthan-Based Materials as a Platform for Heparin Delivery

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