Xanthan-Based Materials as a Platform for Heparin Delivery

Abstract

Heparin (Hep), with its anticoagulant activity, antiangiogenic and apoptotic effects, and growth factor binding, plays an important role in various biological processes. Formulations as drug delivery systems protect its biological activity, and limit the potential side effects of faulty administration. The objective of this study was to develop novel xanthan-based materials as a delivery carrier for heparin. The materials exhibited remarkable elastic behavior and toughness without any crack development within the network, which also support their application for tissue engineering. It was found that all materials possessed the ability to control the release of heparin, according to the Korsmeyer–Peppas release model. All Hep-containing materials caused significant exchanges of the activated partial thromboplastin time (aPTT) and prothrombin time (PT) parameters, indicating that formulated natural/natural synthetic polymeric networks conserved heparin’s biological activity and its ability to interrupt the blood coagulation cascade. The obtained results confirmed that developed materials could be carriers for the controlled release of heparin, with potential applications in topical administration.

Production of Bacterial Exopolysaccharides: Xanthan and Bacterial Cellulose

“…The publications on using xanthan to obtain medical materials have appeared relatively recently. So, in the last two decades, researchers have taken an interest in its future use in drug delivery, tissue engineering, as well as biocomposites with regenerative and antibacterial properties [261][262][263][264][265][266][274][275][276][277][278][284][285][286][287][288][289][321][322][323][324][325][326][327][328].…”

“…Microspheres, hydrogels [284][285][286], pH-responsive nanoparticles [287], and nanogels [288] of xanthan were prepared for the delivery of anticancer drugs used to treat different cancers, including colon cancer. Recently, Anghel et al (2023) developed novel xanthan-based materials as a delivery carrier for heparin [289].…”