Determination of vancomycin in human serum by micellar electrokinetic capillary chromatography with direct sample injection

Kitahashi, Toshihiro; Furuta, Itaru

doi:10.1016/s0009-8981(01)00627-1

Cited by 29 publications

(28 citation statements)

References 10 publications

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“…The concentrations were calculated from the corresponding calibration standard line (experimental concentrations) and were compared with the theoretical concentrations [32][33][34][35][36][37][38]. The extraction recovery was estimated according to Equation 1 and is shown in Table 2.…”

Section: Linearity and Loqmentioning

confidence: 99%

A Simple and Modified Method Development of Vancomycin Using High Performance Liquid Chromatography

Chauhan¹,

Bhatt²

2015

J Chromatogr Sep Tech

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Section: Linearity and Loqmentioning

confidence: 99%

A Simple and Modified Method Development of Vancomycin Using High Performance Liquid Chromatography

Chauhan¹,

Bhatt²

2015

J Chromatogr Sep Tech

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“…Therefore, HPLC has been developed for the analysis of vancomycin in medicines, as well as for the determination in biological fluids 17,24,[26][27][28][29][30][31][32][33][34] . Kitahashi and Furuta 35 developed an assay for measuring vancomycin concentration by micellar electrokinetic capillary chromatography with detection at 210 nm using direct serum injection. The migration time of vancomycin was about 7 min.…”

Section: Clinical Applicationmentioning

confidence: 99%

Untitled

Tariq¹,

Siddiqui²,

Kumar³

et al. 2010

ScienceAsia

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A reverse phase-liquid chromatographic method with UV detection at 280 nm is described for simultaneous determination of ceftriaxone sodium and vancomycin hydrochloride. Chromatographic separation of the two drugs was achieved on a Betasil C-1 column using a mobile phase consisting of a binary mixture of acetonitrile and triethylamine buffer adjusted to pH 3.5 ± 0.1 with orthophosphoric acid in a ratio of 20:80. The liquid chromatographic method developed offers symmetric peak shape, good resolution, and reasonable retention time for both drugs. Linearity, accuracy, and precision were found to be acceptable over the concentration ranges 125-750 ppm for ceftriaxone and 62.5-375 ppm for vancomycin. The liquid chromatographic method was successfully applied to the quality control of formulated products, plasma, and cerebrospinal fluid samples containing ceftriaxone and vancomycin.

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“…Three commercial samples were analyzed, and the content of vancomycin B, the primary component, was determined [27]. Vancomycin was quantitated in human serum using MEKC [28].…”

Section: Polypeptidesmentioning

confidence: 99%

“…An MEKC method of determining vancomycin in serum was developed [28]. In this instance, a 100 mM SDS, 25 mM borate buffer at pH 10.0 permitted the direct injection of the serum following centrifugation.…”

Section: Humanmentioning

confidence: 99%

Analysis of antibiotics by capillary electrophoresis

Flurer

2003

Electrophoresis

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Recent developments in the characterization of antibiotics are reviewed. Many capillary electrophoretic techniques have been utilized in their analyses, addressing various aspects of quantifying, profiling, and monitoring. Laser-induced fluorescence detection systems demonstrated their usefulness in clinical settings and in the monitoring of residue levels in food matrices. Different sample introduction methods have been explored, enhancing detection sensitivity, or reducing or eliminating sample manipulation prior to injection.

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Determination of vancomycin in human serum by micellar electrokinetic capillary chromatography with direct sample injection

Cited by 29 publications

References 10 publications

A Simple and Modified Method Development of Vancomycin Using High Performance Liquid Chromatography

A Simple and Modified Method Development of Vancomycin Using High Performance Liquid Chromatography

Untitled

Analysis of antibiotics by capillary electrophoresis

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