Determination of astemizole, terfenadine and flunarizine hydrochloride by ternary complex formation with eosin and lead(II)

Kelani, Khadiga M.; Bebawy, Lories I.; Abdel-Fattah, Laila

doi:10.1016/s0731-7085(98)00107-1

Cited by 30 publications

(19 citation statements)

References 10 publications

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“…It was found that the binary or ternary complex formed by interaction with eosin alone or eosin and metal measured through spectrofluorimetry offers high sensitivity and selectivity compared to the spectrophotometric analysis. A list of pharmaceuticals reported in table 3 clearly states that spectrofluorimetric methods are more sensitive and have low limit of detection [94][95][96][97][98][99][100][101]. …”

Section: Comparison Of Spectrofluorimetric and Spectrophotometric Metmentioning

confidence: 99%

Utilization of Eosin Dye as an Ion Pairing Agent for Determination of Pharmaceuticals: A Brief Review

Rahman

2017

Int J Pharm Pharm Sci

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Globally, dyes are widely used in the pharmaceutical, food, textile, cosmetics, plastics, leather, paint, ink and paper industries. Eosin is an acidic orange-pink dye and has very strong staining properties. Haematoxylin and eosin Y (H and E) combination is the most common staining and primary diagnostic technique in histo-pathological laboratories. This review mainly discussed the utility of eosin dye in quality control laboratories as an ion pairing agent for drug analysis. Eosin Y is one the most common ion pairing agent and its mono and di anionic forms are capable of interacting with many drug molecules to form colored/fluorescent binary or ternary complexes that can be analyzed with or without extraction by spectrofluorimetry and/or spectrophotometry. Quenching fluorescence and advantages of spectrofluorimetry over spectrophotometry were also discussed. Fluorescence detection greatly enhances the sensitivity and providing a sensitive and relatively inexpensive instrumental method of analysis using eosin Y for various important drugs in pure, commercial dosage forms and biological fluids.

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Section: Comparison Of Spectrofluorimetric and Spectrophotometric Metmentioning

confidence: 99%

Utilization of Eosin Dye as an Ion Pairing Agent for Determination of Pharmaceuticals: A Brief Review

Rahman

2017

Int J Pharm Pharm Sci

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“…The studied drug‐metal ion [Pb(II) (drug) n ] acts as a cation and eosin acts as an anion. Ternary complex formation has been widely used in several reported spectrofluorimetric and spectrophotometric methods .…”

Section: Introductionmentioning

confidence: 99%

Spectrofluorimetric determination of thioridazine and flupentixol in dosage forms; application to content uniformity test

Attia

Omar

2015

Luminescence

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A reliable, sensitive, cheap and non-extractive spectrofluorimetric method has been developed and validated for determination of thioridazine and flupentixol based on ternary complex formation with eosin and lead(II) in the presence of methylcellulose as surfactant at pH 3.2. Under the optimum conditions, the quantitative quenching effect of investigated drugs on the native fluorescence of eosin has been investigated. The quenching of the eosin fluorescence was measured at 517 nm after excitation at 462 nm. The different experimental parameters affecting the development and stability of the reaction products were carefully studied and optimized, and the results were satisfactory. The calibration plots were constructed over the range of 0.5-3.0 µg mL(-1) . The developed method was successfully applied for determination of investigated drugs in commercial tablets without interference from common excipients. It was further applied for content uniformity testing of flupentixol in its tablets. Statistical comparisons of the results with those of the reference methods revealed excellent agreement and indicated no significant difference in accuracy and precision. Copyright © 2015 John Wiley & Sons, Ltd.

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“…The determination of antihistamines in pharmaceutical preparations for its quality control has been performed using several analytical techniques, such as volumetric analysis [2,3], voltametria [4], atomic absorption [5], fluorimetry [6,7], spectrophotometry [8][9][10][11][12], gas chromatography [13] liquid chromatography [14][15][16][17], capillary electrophoresis [18] and micellar electrokinetic chromatography [19,20].…”

Section: Introductionmentioning

confidence: 99%

Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography

Martínez-Algaba

Bermúdez-Saldaña

Villanueva-Camañas

et al. 2006

Journal of Pharmaceutical and Biomedical Analysis

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Determination of astemizole, terfenadine and flunarizine hydrochloride by ternary complex formation with eosin and lead(II)

Cited by 30 publications

References 10 publications

Utilization of Eosin Dye as an Ion Pairing Agent for Determination of Pharmaceuticals: A Brief Review

Utilization of Eosin Dye as an Ion Pairing Agent for Determination of Pharmaceuticals: A Brief Review

Spectrofluorimetric determination of thioridazine and flupentixol in dosage forms; application to content uniformity test

Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography

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