Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography

Martínez-Algaba, C.; Bermúdez-Saldaña, José María; Villanueva-Camañas, R.M.; Sagrado, S.; Medina-Hernández, M.J.

doi:10.1016/j.jpba.2005.07.037

Cited by 71 publications

(38 citation statements)

References 32 publications

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“…Gas chromatographic, HPLC, spectrophotometric, radioimmunoassay, capillary electrophoresis and CL methods have been applied to the analysis of this compound (36)(37)(38)(39)(40)(41)(42)(43)(44)(45)]. Recently, an LC-MS-MS method, using 2-acetamidophenol as an internal standard, was reported for the determination of CPA (46).…”

Section: +mentioning

confidence: 99%

“…Recently, an LC-MS-MS method, using 2-acetamidophenol as an internal standard, was reported for the determination of CPA (46). A micellar liquid chromatography and an ion-pairing RP-HPLC method were also applied to analysis of CPA (39). 4(N,Ndimethylaminosulphonyl)-7-fluoro-2,1,3-benzoxadiazole and bis(2,4,6-trichlorophenyl)-oxalate-hydrogen peroxide were used as post-column CL reagents for CPA following its derivatization with dansyl chloride (40,41).…”

Section: +mentioning

confidence: 99%

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Chemiluminescence determination of chlorpheniramine using tris(1,10‐phenanthroline)–ruthenium(II) peroxydisulphate system and sequential injection analysis

et al. 2008

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] and a peristaltic pump to propel the sample. The experimental conditions affecting the chemiluminescence reaction were systematically optimized, using the univariate approach. Under the optimum conditions linear calibration curves of 0.1-10 mg/ml were obtained. The detection limit was 0.04 mg/ml and the relative standard deviation (RSD) was always < 5%. The procedure was applied to the analysis of CPA in pharmaceutical products and was found to be free from interferences from concomitants usually present in these preparations.

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Section: +mentioning

confidence: 99%

Section: +mentioning

confidence: 99%

Chemiluminescence determination of chlorpheniramine using tris(1,10‐phenanthroline)–ruthenium(II) peroxydisulphate system and sequential injection analysis

et al. 2008

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“…Few analytical methods have been described for simultaneous determination of PC/DH binary mixture including HPLC methods [4][5][6], NIR spectroscopy [7] and multivariate spectrophotometry [8]. A single published literature described the simultaneous quantification of PC and DH in presence of P-amino phenol (PAP); by first derivative ( 1 D) spectrophotometric, the first derivative of ratio spectra ( 1 DD), multivariate spectrophotometric and HPTLC-densitometric methods , in bulk material and pharmaceutical preparations [9].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of paracetamol and diphenhydramine hydrochloride mixture in the presence of their degradation products

Abdelkawy¹,

Abdelhamid²

2013

IOSR-JPBS

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“…Few analytical methods have been described for simultaneous determination of PAR/DPH in their binary mixture including NIR spectroscopy [5], multivariate spectrophotometric method [6], and HPLC methods [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Paracetamol and Diphenhydramine Hydrochloride in Presence of Paracetamol Degradation Product

Ali¹,

Zaazaa²,

Abdelkawy³

et al. 2011

Pharm Anal Acta

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Three sensitive , selective and precise stability indicating methods for simultaneous determination of Paracetamol and Diphenhydramine hydrochloride in their binary mixture and in presence of P-aminophenol; the potential impurity and degradation product of Paracetamol; were developed. In Method A, Paracetamol was determined in presence of Diphenhydramine Hydrochloride and P-aminophenol using the first derivative ( 1 D) spectrophotometric method by measuring the peak amplitude at 264.5 nm where linear relationship was obtained in the range of 2-12 μg mL -1 while Diphenhydramine Hydrochloride was determined in presence of Paracetamol and P-aminophenol using the first derivative of ratio spectra ( 1 DD) method at 224 nm. Method B utilized chemometric techniques [Principal Component Regression (PCR) and Partial Least Squares(PLS)] which successfully applied to quantify both drugs and degradation product using the information included in the absorption spectra of appropriate solutions of the three compounds in the range of 220-340nm. Method C used HPTLC-densitometric method in which the aforementioned components were separated on silica gel plates using chloroform-ethyl acetate-ammonia solution (4:6:0.2, by volume) as a developing system. This was followed by quantitative densitometric measurement at 220 nm .Linear relationship were obtained in the concentration ranges of 0.4-1.6 μg/band , 3-12 μg /band and 0.4-1.6 μg/band for Paracetamol, Diphenhydramine Hydrochloride and P-aminophenol respectively. The proposed methods have been successfully applied to the analysis of Paracetamol and Diphenhydramine Hydrochloride in their pharmaceutical formulation without interference from other dosage form additives and the results were statistically compared with official method .

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Analysis of pharmaceutical preparations containing antihistamine drugs by micellar liquid chromatography

Cited by 71 publications

References 32 publications

Chemiluminescence determination of chlorpheniramine using tris(1,10‐phenanthroline)–ruthenium(II) peroxydisulphate system and sequential injection analysis

Chemiluminescence determination of chlorpheniramine using tris(1,10‐phenanthroline)–ruthenium(II) peroxydisulphate system and sequential injection analysis

Simultaneous determination of paracetamol and diphenhydramine hydrochloride mixture in the presence of their degradation products

Simultaneous Determination of Paracetamol and Diphenhydramine Hydrochloride in Presence of Paracetamol Degradation Product

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