Simultaneous determination of paracetamol and diphenhydramine hydrochloride mixture in the presence of their degradation products

Abdelkawy, Mohamed; Abdelhamid, Nessreen S.

doi:10.9790/3008-0654452

Cited by 8 publications

(7 citation statements)

References 7 publications

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“…Hence, there is no official method available for assay of combined dose formulation containing DPH and NPS. Literature survey revealed a few spectrophotometric, 5 high-performance liquid chromatography (HPLC), [6][7][8] and HPTLC 9,10 methods reported for the determination of DPH and NPS in combination with other drugs. There is only one HPLC method reported in literature for simultaneous determination of DPH and NPS in tablets.…”

Section: Introductionmentioning

confidence: 99%

A High-Performance Thin Layer Chromatography (HPTLC) Method for Simultaneous Determination of Diphenhydramine Hydrochloride and Naproxen Sodium in Tablets

et al. 2015

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A rapid and simple high-performance thin layer chromatography (HPTLC) method with densitometry at 230 nm was developed and validated for simultaneous determination of diphenhydramine hydrochloride (DPH) and naproxen sodium (NPS) from pharmaceutical preparation. The separation was carried out on aluminum plates precoated with silica gel 60 F254 using mobile phase toluene:methanol:glacial acetic acid (7.5:1:0.2, v/v/v). The linearity range lies between 200 and 1200 ng/band for DPH and 1760 and 10,560 ng/band for NPS with correlation coefficients of 0.994 and 0.995, respectively. The Rf value for DPH is 0.20 ± 0.05 and for NPS is 0.61 ± 0.06. % Recoveries of DPH and NPS was in the range of 99.70%–99.95% and 99.63%–99.95%, respectively. Limit of detection value for DPH was 13.21 ng/band and for NPS was 8.03 ng/band. Limit of quantitation value for DPH was 40.06 ng/band and for NPS was 24.34 ng/band. The developed method was validated as per ICH guidelines. In stability testing, DPH was found unstable to acid and alkaline hydrolysis, and DPH and NPS were found unstable to oxidation, whereas both the drugs were stable to neutral and photodegradation. The proposed method was successfully applied for the routine quantitative analysis of dosage form containing DPH and NPS.

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Section: Introductionmentioning

confidence: 99%

A High-Performance Thin Layer Chromatography (HPTLC) Method for Simultaneous Determination of Diphenhydramine Hydrochloride and Naproxen Sodium in Tablets

et al. 2015

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“…Chromatographic methods: Determination of oxeladine citrate in the presence of two of its degradation products by HPTLC and HPLC was performed [20]. Objectives of this study are hydrolytic and the oxidative degradation of oxeladin citrate, to prepare its alkaline induced hydrolytic degradation product, α,α-diethyl benzeneacetic acid and its ric method (A), while in area under curve (AUC) method (B) the zero order spectrum of olopatadine hydrochloride was measured in between 220 nm to 230 nm.…”

Section: Methods Of Determinationmentioning

confidence: 99%

Review Article: Instrumental Analysis of Olopatadine Hydrochloride, Oxeladine Citrate, Amlodipine Besylate and Xipamide

M¹,

E²,

M³

et al. 2020

Int J Analyt Bioanalyt Methods

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In this literature review, we will introduce all reported methods that have been developed for determination of the antihistaminic drug, olopatadine HCl, the cough suppressant drug oxeladine citrate, and certain antihypertensive drugs such as amlodipine besylate and xipamide in their pure form, combined form with other drugs, combined form with degradation products, and in biological samples. We also will shed the light on the most important combination of drugs that are used for treatment of allergy and hypertension.

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“…Yet, all of the published work were focused on the determination of PAR and ASP combination along with other compounds using HPLC [14] , [15] , [16] , [17] , [18] , UV-Spectrophotometry [19] , [20] , [21] , and voltammetry [22] , [23] . Similarly, PAR and DIPH combination was analyzed by different spectrophotometric [24] , [25] , [26] , HPLC [26] , [27] , and capillary gas chromatographic [28] methods.…”

Section: Introductionmentioning

confidence: 99%

Sustainable liquid chromatographic determination and purity assessment of a possible add-on triple-action over-the-counter pharmaceutical combination in COVID-19

Marzouk

Ibrahim²,

Hegazy

et al. 2022

Microchemical Journal

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Simultaneous determination of paracetamol and diphenhydramine hydrochloride mixture in the presence of their degradation products

Cited by 8 publications

References 7 publications

A High-Performance Thin Layer Chromatography (HPTLC) Method for Simultaneous Determination of Diphenhydramine Hydrochloride and Naproxen Sodium in Tablets

A High-Performance Thin Layer Chromatography (HPTLC) Method for Simultaneous Determination of Diphenhydramine Hydrochloride and Naproxen Sodium in Tablets

Review Article: Instrumental Analysis of Olopatadine Hydrochloride, Oxeladine Citrate, Amlodipine Besylate and Xipamide

Sustainable liquid chromatographic determination and purity assessment of a possible add-on triple-action over-the-counter pharmaceutical combination in COVID-19

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