A High-Performance Thin Layer Chromatography (HPTLC) Method for Simultaneous Determination of Diphenhydramine Hydrochloride and Naproxen Sodium in Tablets

Bhole, Ritesh P.; Shinde, Swapnil; Chitlange, Sohan S.; Wankhede, Sagar B.

doi:10.4137/aci.s31506

Cited by 30 publications

(24 citation statements)

References 4 publications

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“…For detecting the presence of phytochemicals the initial concentration of extracts selected was 10mg/ml and 10µl sample was loaded on to the TLC sheets. Extracts were loaded on Silica gel 60 F254 TLC aluminium sheets (5×7.5 cm) (Merck) were used to perform analysis (Aliyu, 2011;Bhole, 2015;Szymulanska-Ramamurthy, 2017). Details of solvent systems, developing reagents and positive observations are as mentioned in the table below and are different for according to phytochemical.…”

Section: F Primary Phytochemical Screening By Tlcmentioning

confidence: 99%

Medicinal and Phytochemical Analysis of Alcoholic Whole Fruit Extracts of Actinidia Deliciosa

Mulye¹,

Maurya²,

Kamble³

et al. 2020

JSR

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Present study investigates antimicrobial, antioxidant activity and phytochemical profiling of alcoholic extracts of whole fruit of Actinidia deliciosa (kiwi fruit). Cold and hot extracts of whole Actinidia deliciosa fruit prepared in methanol and ethanol and their different concentrations were tested against common nosocomial infections and human pathogens of skin, gestrointestinal tract and upper respiratory tract. Extracts were evaluated for their phytochemical constituents and antioxidant activity. Cold ethanolic extract of whole kiwi fruit has good antimicrobial activity as it inhibited the growth of almost all test organisms at concentration less than 20 mg/ml. Cold ethanolic extract was also found to be effective against Candida albicans at a concentration of 38.33 mg/ml. Antioxidant activity was examined by DPPH radical scavenging assay, highest antioxidant activity was displayed by cold methanolic extract. The qualitative phytochemical analysis of the extracts revealed the presence of alkaloids, flavonoids, saponins, cardiac glycosides, tannins and terpenoids in whole fruit of Actinidia deliciosa.

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Section: F Primary Phytochemical Screening By Tlcmentioning

confidence: 99%

Medicinal and Phytochemical Analysis of Alcoholic Whole Fruit Extracts of Actinidia Deliciosa

Mulye¹,

Maurya²,

Kamble³

et al. 2020

JSR

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“…Its advantages such as high selectivity and efficiency, low detection limits, no carry-over [70,71]. The potential of HPTLC in combination with MS to identify drugs and metabolites in urine was already demonstrated in 1999 by Tames et al [72].…”

Section: (I) State-of-the-art Chromatographymentioning

confidence: 99%

Quantitative mass spectrometry methods for pharmaceutical analysis

Loos¹,

Schepdael²,

Cabooter³

2016

Phil. Trans. R. Soc. A.

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Quantitative pharmaceutical analysis is nowadays frequently executed using mass spectrometry. Electrospray ionization coupled to a (hybrid) triple quadrupole mass spectrometer is generally used in combination with solid-phase extraction and liquid chromatography. Furthermore, isotopically labelled standards are often used to correct for ion suppression. The challenges in producing sensitive but reliable quantitative data depend on the instrumentation, sample preparation and hyphenated techniques. In this contribution, different approaches to enhance the ionization efficiencies using modified source geometries and improved ion guidance are provided. Furthermore, possibilities to minimize, assess and correct for matrix interferences caused by co-eluting substances are described. With the focus on pharmaceuticals in the environment and bioanalysis, different separation techniques, trends in liquid chromatography and sample preparation methods to minimize matrix effects and increase sensitivity are discussed. Although highly sensitive methods are generally aimed for to provide automated multi-residue analysis, (less sensitive) miniaturized set-ups have a great potential due to their ability for in-field usage. This article is part of the themed issue ‘Quantitative mass spectrometry’.

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“…This leads to the increase of vascular smooth muscle contraction, so reducing the redness, hyperthermia and edema that occur during an inflammatory reaction. Several techniques were published for the estimation of DPH in pharmaceutical formulations and in biological fluids including: spectrophotometry [2-5], potentiometric [6], high performance liquid chromatography [7,8], liquid chromatography [9] and capillary electrophoresis [10,11].…”

Section: Introductionmentioning

confidence: 99%

Charge-transfer interaction between antihistamine antiallergic drugs, diphenhydramine, fexofenadine, cetirizine and two π-acceptors in pharmaceutical forms

El‐Didamony

Ramadan²

2020

SN Appl. Sci.

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Two simple and sensitive spectrophotometric techniques have been proposed for the estimation of antihistamine drugs, diphenhydramine hydrochloride (DPH), fexofenadine hydrochloride (FXO) and cetirizine dihydrochloride (CTZ) in pure forms and in their pharmaceutical forms via charge-transfer complex formation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and 7,7,8,8-tetracyanoquinodimethane (TCNQ) reagents. Spectrophotometric methods involve the addition a known excess of DDQ or TCNQ reagents to DPH, FXO and CTZ drugs in acetonitrile, followed by the measurement of the absorbance of formed CT complexes at the selected wavelength. Various variables and parameters affecting the reactions were studied and investigated. Beer's law was obeyed in the concentration ranges of 16-144, 12-120, 12-86 μg mL −1 and 6-66, 24-216 and 4-68 μg mL −1 for DPH, FXO and CTZ drugs using DDQ and TCNQ reagents, respectively, with correlation coefficients not less than 0.9944. The reaction stoichiometry is found to be 1:1 [drug]: [DDQ or TCNQ]. For the spectrophotometric methods, molar absorptivity, detection and quantification limits, and sandell resistance are also calculated. According to ICH guidelines, both intra-and inter-day precision and reliability were evaluated. The estimated techniques have been successfully applied in their medicinal forms to the determination of the cited drugs. The finding showed no significant difference between the estimated methods and reported methods, depended on t test and variance ratio. Popular pharmaceutical additives did not interfere.

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A High-Performance Thin Layer Chromatography (HPTLC) Method for Simultaneous Determination of Diphenhydramine Hydrochloride and Naproxen Sodium in Tablets

Cited by 30 publications

References 4 publications

Medicinal and Phytochemical Analysis of Alcoholic Whole Fruit Extracts of Actinidia Deliciosa

Medicinal and Phytochemical Analysis of Alcoholic Whole Fruit Extracts of Actinidia Deliciosa

Quantitative mass spectrometry methods for pharmaceutical analysis

Charge-transfer interaction between antihistamine antiallergic drugs, diphenhydramine, fexofenadine, cetirizine and two π-acceptors in pharmaceutical forms

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