Chemiluminescence determination of chlorpheniramine using tris(1,10‐phenanthroline)–ruthenium(II) peroxydisulphate system and sequential injection analysis

Abstract

] and a peristaltic pump to propel the sample. The experimental conditions affecting the chemiluminescence reaction were systematically optimized, using the univariate approach. Under the optimum conditions linear calibration curves of 0.1-10 mg/ml were obtained. The detection limit was 0.04 mg/ml and the relative standard deviation (RSD) was always < 5%. The procedure was applied to the analysis of CPA in pharmaceutical products and was found to be free from interferences from concomitants usually present in these preparations.

Peroxyoxalate chemiluminescence detection for the highly sensitive determination of fluorescence-labeled chlorpheniramine with Suzuki coupling reaction

“…fold that of other CL methods [30,31] for the determination of CPA. Also, the detection limit of the proposed method was almost same as that of HPLC-MS methods [20,32,33].…”

“…Various analytical methods have been developed for the determination of CPA, some of these are based on HPLC with FL detection [22,23], HPLC with UV detection [24 -28], capillary electrophoresis with UV detection [29], sequential injection analysis with electro-chemiluminescence detection [30,31]. However, these methods lack the sensitivity for the determination of CPA in biological samples.…”

Chemiluminescence Determination of Local Anaesthetic Mepivacaine in Human Plasma and Pharmaceuticals

“…[28][29][30][31][32] The CL kinetic profiles of some of investigated compounds presented in Table 1 are very or relatively sharp so that their CL intensity is little or approximately equal to zero at 10 s after starting CL reaction. Therefore, they have little or zero blank interferences for the determination of mepivacaine which have a broad CL time profile with a detectable response at 10 s after injection of Ce(IV) solution.…”

Sensitive determination of epinephrine in pharmaceutical preparation by flow injection coupled with chemiluminescence detection and mechanism study

“…In comparison with these detection modes, chemiluminescence (CL) detection has been proven to be one of the most powerful techniques for the analysis of various analytes including metal ions (19,20), biological matrices (21)(22)(23)(24)(25), and pharmaceutical preparations (26,27) owing to its high sensitivity and simplicity, and has been used in the determination of EP (28)(29)(30). Analytical procedures applying CL detection in FIA setups integrated the advantages of simplicity, rapidity and reproducibility, and were appropriate for on-line analysis (31,32). However, most of the FIA-CL methods for the determination of EP employ indirect CL detection.…”