Determination of antimalarial compound, ARB-89 (7β-hydroxy-artemisinin carbamate) in rat serum by UPLC/MS/MS and its application in pharmacokinetics

Pabbisetty, Deepthi; Illendula, Anuradha; Muraleedharan, K.; Chittiboyina, Amar G.; Williamson, John S.; Avery, Mitchell A.; Avery, Bonnie A.

doi:10.1016/j.jchromb.2012.02.007

Cited by 9 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Weighted (1/ × 2 ) linear least‐squares regression was used as the mathematical model. The LLOQ was determined as the lowest concentration that produced a signal/noise ratio of 5 (Pabbisetty et al, ). The limit of detection (LOD) was determined as the lowest concentration that produced a signal/noise ratio of 3 (Fan et al, ).…”

Section: Methodsmentioning

confidence: 99%

Determination of antibacterial agent tilmicosin in pig plasma by LC/MS/MS and its application to pharmacokinetics

Shi-Yue²,

Zhou

et al. 2016

Biomedical Chromatography

View full text Add to dashboard Cite

A rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to quantify tilmicosin in pig plasma. Plasma samples were prepared by liquid-liquid extraction. Chromatographic separation was achieved on a C column (2.1 × 30 mm, 3.5 μm) using acetonitrile-water (90:10, v/v; water included 0.1% formic acid) as the mobile phase. Mass detection was carried out using positive electrospray ionization in multiple reaction monitoring mode. The calibration curve was linear from 0.5 to 2000 ng/mL (r = 0.9998). The intra- and inter-day accuracy and precision were within the acceptable limits of ±10% for all tilmicosin concentrations. The recoveries ranged from 95 to 99% for the three tested concentrations. The LC-MS/MS method described herein was simple, fast and less laborious than other methods, achieved high sensitivity using a small sample volume, and was successfully applied to pharmacokinetic studies of tilmicosin enteric granules after oral delivery to pigs. In comparison with tilmicosin premix, tilmicosin enteric granules slowed the elimination rate of tilmicosin, prolonged its period of action and significantly improved its bioavailability.

show abstract

Section: Methodsmentioning

confidence: 99%

Determination of antibacterial agent tilmicosin in pig plasma by LC/MS/MS and its application to pharmacokinetics

Shi-Yue²,

Zhou

et al. 2016

Biomedical Chromatography

View full text Add to dashboard Cite

show abstract

“…Artemisinin‐based drugs and their metabolites are prone to in‐source fragmentation under atmospheric pressure ionization mass spectrometry (API‐MS) conditions . The detection was performed on a triple‐quadrupole tandem mass spectrometer in positive electrospray ionization (ESI + ) mode.…”

Section: Resultsmentioning

confidence: 99%

Determination of artemisitene in rat plasma by ultra‐performance liquid chromatography/tandem mass spectrometry and its application in pharmacokinetics

Chen

et al. 2017

Rapid Comm Mass Spectrometry

View full text Add to dashboard Cite

show abstract

“…In addition, there is evidence that the introduction, at the location of the hydroxyl group, of radicals such as ethyl or n-propyl increases the pharmacological activity of the artemisinin molecule (Avery et al, 2003). Also, some substituted derivatives obtained by chemists from 7âhydroxyartemisinin have shown increased solubility in water and excellent antimalarial activity in vitro (Pabbisetty et al, 2012). It is not known yet how such substituents will behave at the C-5 position of the artemisinin molecule.…”

Section: Discussionmentioning

confidence: 99%

Microbial transformation of the antimalarial and anticancer drug artemisinin by white-rot basidiomycetes

Parshikov¹,

Hernandes-Luna²,

Zaraisky³

2018

View full text Add to dashboard Cite

We studied transformation of the potential anticancer drug artemisinin by the white-rot basidiomycetes Pycnoporus sanguineus and Funalia trogii. The fungi were grown on sucrose-malt broth in the presence of artemisinin for 14 days. Transformation products were extracted with ethyl acetate and analyzed by HPLC. Each of the fungi produced only a single metabolite from artemisinin. Products of transformation were identified by mass spectrometry and NMR methods. 5β-Hydroxyartemisinin was isolated from the incubation medium of P. sanguineus in 92.1% yield and 7β-hydroxyartemisinin was isolated from the incubation medium of F. trogii in 89.7% yield.

show abstract

Determination of antimalarial compound, ARB-89 (7β-hydroxy-artemisinin carbamate) in rat serum by UPLC/MS/MS and its application in pharmacokinetics

Cited by 9 publications

References 19 publications

Determination of antibacterial agent tilmicosin in pig plasma by LC/MS/MS and its application to pharmacokinetics

Determination of antibacterial agent tilmicosin in pig plasma by LC/MS/MS and its application to pharmacokinetics

Determination of artemisitene in rat plasma by ultra‐performance liquid chromatography/tandem mass spectrometry and its application in pharmacokinetics

Microbial transformation of the antimalarial and anticancer drug artemisinin by white-rot basidiomycetes

Contact Info

Product

Resources

About