Biocatalysis of artemisinin by different strains of Mucor ramannianus à illustrates a simple approach to bioengineering for attaining useful biotransformation strains for preparative or downstream development. Three different strains of M. ramannianus on the malt=sucrose medium were compared for their native ability to metabolize the antimalarial artemisinin and produce significant yields of hydroxylated artemisinin derivatives. The M. ramannianus strains transformed the antimalarial into hydroxylated metabolites, in particular 7b-hydroxyartemisinin at 88% yield and 6b-hydroxyartemisinin at 51% yield. M. ramannianus strains: M. ramannianus 1839, University of Wisconsin, M. ramannianus ATCC 9624, American Typical Cultures Collection, M. ramannianus ATCC MYA-883 (R-56), Jefferson County, Arkansas (American Typical Cultures Collection).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.