Detection of muscle gap by L-BIA in muscle injuries: clinical prognosis

Nescolarde, Lexa; Yanguas, Javier; Terricabras, Joaquim; Lukaski, Henry C.; Alomar, Xavier; Rosell, J.; Rodas, Gil

doi:10.1088/1361-6579/aa7243

Cited by 39 publications

(32 citation statements)

References 16 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This finding reinforces the notion that a low PA is associated with sarcopenia, a key biological substrate of the frailty syndrome that results from accelerated age‐related loss of skeletal muscle mass and strength 31. PA has previously been shown to correlate with biomarkers of muscle degeneration32 and to decrease after muscle injury,33, 34, 35 supporting the biological plausibility of a link between decreased PA and not only low muscle mass, but also impaired muscle function. More important, the addition of low PA to risk models that included the SPPB demonstrated incremental prognostic value, highlighting the complementary relationship between PA and existing frailty scales.…”

Section: Discussionsupporting

confidence: 83%

Phase Angle as a Biomarker for Frailty and Postoperative Mortality: The BICS Study

Mullie

O’Brand

Bendayan

et al. 2018

JAHA

View full text Add to dashboard Cite

BackgroundPhase angle (PA) is a bioimpedance measurement that is determined lean body mass and hydration status. Patients with low PA values are more likely to be frail, sarcopenic, or malnourished. Previous work has shown that low PA predicts adverse outcomes after cardiac surgery, but the effect of PA on survival has not previously been assessed in this setting.Methods and ResultsThe BICS (Bioimpedance in Cardiac Surgery) study recruited 277 patients undergoing major cardiac surgery at 2 university‐affiliated hospitals in Montreal, QC, Canada. Bioimpedance measurements as well as frailty and nutritional assessments were performed preoperatively. The primary outcome was all‐cause mortality. Secondary outcomes were 30‐day mortality, postoperative morbidity, and hospital length of stay. There were 10 deaths at 1 month of follow‐up and 16 deaths at 12 months of follow‐up. PA was associated with age, sex, body mass index, comorbidities, and frailty, as measured by the Short Physical Performance Battery and Fried scales. After adjusting for Society of Thoracic Surgeons–predicted mortality, lower PA was associated with higher mortality at 1 month (adjusted odds ratio, 3.57 per 1° decrease in PA; 95% confidence interval, 1.35–9.47) and at 12 months (adjusted odds ratio, 3.03 per 1° decrease in PA; 95% confidence interval, 1.30–7.09), a higher risk of overall morbidity (adjusted hazard ratio, 2.51 per 1° decrease in PA; 95% confidence interval, 1.32–4.75), and a longer hospital length of stay (adjusted β, 4.8 days per 1° decrease in PA; 95% confidence interval, 1.3–8.2 days).ConclusionsLow PA is associated with frailty and is predictive of mortality, morbidity, and length of stay after major cardiac surgery. Further work is needed to determine the responsiveness of PA to interventions aimed at reversing frailty.

show abstract

Section: Discussionsupporting

confidence: 83%

Phase Angle as a Biomarker for Frailty and Postoperative Mortality: The BICS Study

Mullie

O’Brand

Bendayan

et al. 2018

JAHA

View full text Add to dashboard Cite

show abstract

“…10 Studies have shown that PhA reductions are directly related to severity of muscle injury. [11][12][13] For example, Nescolarde et al 12 demonstrated that reduced PhA was directly related to different levels of muscular injuries. These findings highlight the sensitivity of PhA to identify cell integrity.…”

Section: Introductionmentioning

confidence: 99%

Correlations between resistance training‐induced changes on phase angle and biochemical markers in older women

Tomeleri

Ribeiro

Cavaglieri

et al. 2018

Scandinavian Med Sci Sports

View full text Add to dashboard Cite

The main purpose of this study was to investigate the effects of 12 weeks of resistance training (RT) on phase angle (PhA), inflammatory and oxidative stress biomarkers, and to evaluate whether these RT-induced adaptations are related to PhA changes. Fifty-one older women (70.6 ± 5.1 years; 26.9 ± 4.2 kg/m ) were randomly allocated into a training group (TG) that performed 12-week RT or a nonexercising control group (CG). The PhA (Xitron), body composition (DXA), and blood sample measurements (after a 12 hours fast) were performed before and after the intervention. The TG showed a significant (P < .05) increase in PhA (TG: +7.4±5.9% vs CG: -3.6 ± 8.8%), and interleukin-10 (IL-10; TG: +51.8 ± 71.1% vs CG: -46.6 ± 38.0%), and a decrease in tumor necrosis factor alpha (TNF-α; TG: -15.2 ± 11.1% vs CG: +6.9±17.7%), interleukin-6 (IL-6; TG: -17.9 ± 17.8% vs CG: +6.1 ± 24.8%), and C-reactive protein (CRP; TG: -24.1 ± 19.9% vs CG: +43.8 ± 31.1%). Moreover, TG upregulated catalase (TG: +11.4 ± 15.0% vs CG: -6.7 ± 10.2%). Changes in TNF-α (r = -.71), CRP (r = -.65), lower advanced oxidation protein products (r = -.55), and catalase (r = +.73) after RT were correlated with changes in PhA (P < .05). These results suggest that RT improves PhA, inflammatory and oxidative stress biomarkers, and the changes in inflammatory and oxidative damage markers are correlated with changes in PhA.

show abstract

“…The aim of collecting these measurements is to provide details regarding the electrochemical structures and processes within a tissue or material under study [1]. These measurements are being used in a wide range of applications including: As a method to monitor hydration during hemodialysis [2], to detect changes resulting from muscle injury [3], assessing lympoedema [4], and to assess neuromuscular disorders [5]. There is also a small set of studies that have investigated the bioimpedance of skeletal muscle for changes that result from fatigue [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Fatigue-Induced Cole Electrical Impedance Model Changes of Biceps Tissue Bioimpedance

Freeborn

2018

Fractal Fract

View full text Add to dashboard Cite

Bioimpedance, or the electrical impedance of biological tissues, describes the passive electrical properties of these materials. To simplify bioimpedance datasets, fractional-order equivalent circuit presentations are often used, with the Cole-impedance model being one of the most widely used fractional-order circuits for this purpose. In this work, bioimpedance measurements from 10 kHz to 100 kHz were collected from participants biceps tissues immediately prior and immediately post completion of a fatiguing exercise protocol. The Cole-impedance parameters that best fit these datasets were determined using numerical optimization procedures, with relative errors of within approximately ± 0.5 % and ± 2 % for the simulated resistance and reactance compared to the experimental data. Comparison between the pre and post fatigue Cole-impedance parameters shows that the R ∞ , R 1 , and f p components exhibited statistically significant mean differences as a result of the fatigue induced changes in the study participants.

show abstract

Detection of muscle gap by L-BIA in muscle injuries: clinical prognosis

Abstract: These results show that L-BIA could aid MRI and US in identifying the severity of an injured muscle according to muscle gap and therefore to accurately predict the RTP.

Cited by 39 publications

References 16 publications

Phase Angle as a Biomarker for Frailty and Postoperative Mortality: The BICS Study

Phase Angle as a Biomarker for Frailty and Postoperative Mortality: The BICS Study

Correlations between resistance training‐induced changes on phase angle and biochemical markers in older women

Fatigue-Induced Cole Electrical Impedance Model Changes of Biceps Tissue Bioimpedance

Contact Info

Product

Resources

About