Phase Angle as a Biomarker for Frailty and Postoperative Mortality: The BICS Study

Abstract

BackgroundPhase angle (PA) is a bioimpedance measurement that is determined lean body mass and hydration status. Patients with low PA values are more likely to be frail, sarcopenic, or malnourished. Previous work has shown that low PA predicts adverse outcomes after cardiac surgery, but the effect of PA on survival has not previously been assessed in this setting.Methods and ResultsThe BICS (Bioimpedance in Cardiac Surgery) study recruited 277 patients undergoing major cardiac surgery at 2 university‐affiliated hospitals in Montreal, QC, Canada. Bioimpedance measurements as well as frailty and nutritional assessments were performed preoperatively. The primary outcome was all‐cause mortality. Secondary outcomes were 30‐day mortality, postoperative morbidity, and hospital length of stay. There were 10 deaths at 1 month of follow‐up and 16 deaths at 12 months of follow‐up. PA was associated with age, sex, body mass index, comorbidities, and frailty, as measured by the Short Physical Performance Battery and Fried scales. After adjusting for Society of Thoracic Surgeons–predicted mortality, lower PA was associated with higher mortality at 1 month (adjusted odds ratio, 3.57 per 1° decrease in PA; 95% confidence interval, 1.35–9.47) and at 12 months (adjusted odds ratio, 3.03 per 1° decrease in PA; 95% confidence interval, 1.30–7.09), a higher risk of overall morbidity (adjusted hazard ratio, 2.51 per 1° decrease in PA; 95% confidence interval, 1.32–4.75), and a longer hospital length of stay (adjusted β, 4.8 days per 1° decrease in PA; 95% confidence interval, 1.3–8.2 days).ConclusionsLow PA is associated with frailty and is predictive of mortality, morbidity, and length of stay after major cardiac surgery. Further work is needed to determine the responsiveness of PA to interventions aimed at reversing frailty.

Malnutrition and Survival – Bioimpedance Data in Head Neck Cancer Patients

“…We observed that a PA<5˚ was a sufficient threshold for identifying HNC patients with a shorter median survival. These results correspond to a study of patients undergoing cardiac surgery, where a PA<4.5˚ was indicative for a higher frailty and mortality (19). Another study on palliative care patients suffering mainly from gastric cancer set the PA threshold at <4˚.…”

Decreased Bioimpedance Phase Angle in Patients with Diabetic Chronic Kidney Disease Stage 5

“…Generally, a low PhA may suggest deterioration of the cell membrane and cellular dysfunction. A low PhA is associated with frailty [15][16][17] as well as being associated with sarcopenia [18][19][20]. In this study, there was a significant association between the PhA and OH/ECW, but we excluded OH/ECW from the multivariate analysis.…”

Bioelectrical Impedance Analysis-derived Phase Angle as a Determinant of Protein-energy Wasting and Frailty in Maintenance Hemodialysis Patients: retrospective cohort study

“…Moreover, low PA was a greater risk factor for frailty even after adjusting for other clinical indicators. Several prior studies have reported an association between low PA and frailty phenomenon in older subjects, 17,18 or cardiac surgery patients, 19 although very few studies have focused on HD patients. 20 In the present study, we also determined that low PA is a representative comprehensive biomarker of malnutrition, frailty, as well as hydration in HD patients.…”