Fatigue-Induced Cole Electrical Impedance Model Changes of Biceps Tissue Bioimpedance

Abstract

Bioimpedance, or the electrical impedance of biological tissues, describes the passive electrical properties of these materials. To simplify bioimpedance datasets, fractional-order equivalent circuit presentations are often used, with the Cole-impedance model being one of the most widely used fractional-order circuits for this purpose. In this work, bioimpedance measurements from 10 kHz to 100 kHz were collected from participants biceps tissues immediately prior and immediately post completion of a fatiguing exercise protocol. The Cole-impedance parameters that best fit these datasets were determined using numerical optimization procedures, with relative errors of within approximately ± 0.5 % and ± 2 % for the simulated resistance and reactance compared to the experimental data. Comparison between the pre and post fatigue Cole-impedance parameters shows that the R ∞ , R 1 , and f p components exhibited statistically significant mean differences as a result of the fatigue induced changes in the study participants.

Cole-impedance parameters representing biceps tissue bioimpedance in healthy adults and their alterations following eccentric exercise

“…The resistance of a tissue is related to the concentration of dissolved ions in the biological medium [26] , therefore and of the Cole-impedance model are expected to be associated with the intracellular and extracellular fluid in a tissue. This is supported by decreases in and for study participants bicep bioimpedance post exercise [15] . While the resistance parameters showed a decrease, Freeborn and Fu reported no statistically significant differences in the pre/post exercise CPE parameters ( ) of the study participants bicep tissues [15] .…”

“…Bioimpedance is also currently being investigated as a noninvasive technique to characterize skeletal muscle tissue with a particular focus on assessing neuromuscular disorders [10] , [11] , [2] . Beyond assessing neuromuscular disorders, bioimpedance is being investigated to monitor tissue changes that result from the exercise and fatigue of skeletal muscle, with decreases in impedance magnitude reported after resistance training protocols [12] , [13] , [14] , [15] , [16] , with further results reporting decreased in impedance magnitude for acute muscle injury [17] , [18] .…”

“…Regardless of the application, when analyzing collected bioimpedance data two approaches are typically adopted: (i) analyzing a single or multiple discrete frequencies [17] , [12] , [13] , [16] or (ii) reducing a multi-frequency impedance spectra to an equivalent circuit representation [20] , [14] , [15] . While analyzing discrete frequencies is useful to identify if changes are occurring, it is difficult to link these changes to specific properties of the tissue and its structure.…”

“…The Cole-impedance model has been used to represent the 10–100 kHz bioimpedance of the biceps tissues of healthy adults before and after participation in an isotonic exercise protocol [14] , [15] ; where Freeborn and Fu reported statistically significant decreases in the resistance parameters of the Cole-impedance model ( ) comparing the pre-exercise and post-exercise measures [15] . The resistance of a tissue is related to the concentration of dissolved ions in the biological medium [26] , therefore and of the Cole-impedance model are expected to be associated with the intracellular and extracellular fluid in a tissue.…”

Low-Cost, Compact, and Rapid Bio-Impedance Spectrometer with Real-Time Bode and Nyquist Plots

“…Properties of electrical impedance have been reported to understand the nature and behavior of cell [4][5][6][7][8], bacteria detection and identification [9,10], identification of beverages and food ingredients [11][12][13][14][15][16], and so on. In the medical field, BIS is used to characterizations of serum and blood [17][18][19], identification of body composition and disease [20][21][22], and to assist the process of diagnosis and functional electrical stimulation of the body [23][24][25]. Research on BIS, as mentioned, mostly covers α and β dispersion, and is carried out using a frequency of 10 Hz to 1 MHz.…”